CAS: 111-33-1; N1,N3-Dimethylpropane-1,3-Diamine

相似化合物

442514-22-9 10239-34-6 1253582-19-2

上下游产品

CAS号67-56-1 甲醇 | CAS号109-76-2 1,3-丙二胺 | CAS号109-64-8 1,3-二溴丙烷 | CAS号74-89-5 氨基甲烷 | CAS号77-78-1 硫酸二甲酯 | CAS号7226-23-5 N,N-二甲基丙烯基脲 | CAS号1606-49-1 1,4,5,6-四氢嘧啶 | CAS号74-88-4 碘甲烷 | CAS号10556-96-4 pyrimidine, hex... | CAS号7226-23-5 N,N-二甲基丙烯基脲 | CAS号132625-05-9 N,N'-dimethyl-N... | CAS号3693-07-0 1,3-dimethyl-2-... | CAS号124-40-3 二甲胺 | CAS号6063-68-9 2-butyl-1,3-dim... | CAS号5898-36-2 1,2,3-trimethyl... | CAS号70-55-3 对甲苯磺酰胺 | CAS号36147-71-4 N,N'-dimethyl-N... | CAS号554-68-7 三乙胺盐酸盐

N,N-二甲基丙烯基脲置于potassium Hydroxide体系中,用83%的收率获得n,N'-二甲基-1,3-丙二胺
参考文献:一种制备n,N'-二甲基乙二胺和n,N'-二甲基-1,3-丙二胺的新方法
标题:一种制备n,N'-二甲基乙二胺和n,N'-二甲基-1,3-丙二胺的新方法
摘要:本发明涉及一种制备n,N'‑二甲基乙二胺和n,N'‑二甲基‑1,3‑丙二胺的新方法.该方法以1,3‑二甲基‑2‑咪唑啉酮或1,3‑二甲基‑四氢‑2‑嘧啶酮为原料,加入适当的碱进行加热开环反应,制备n,N'‑二甲基乙二胺和n,N'‑二甲基‑1,3‑丙二胺.本方法完全避免了传统方法以胺为原料进行烷基化副产物多的问题.本方法操作简便,收率高,三废少,所得产物纯度高,易于实现工业化.

专利信息

专利号:WO-9837078-A1
优先权日:1997-02-20
标题 :Solid phase and combinatorial synthesis of substituted thiophenes and of arrays of substituted thiophenes
发明人：DOERWALD FLORENCIO ZARAGOZA
权利人:NOVO NORDISK AS
摘要:A solid phase method for the synthesis of a plurality of differently substituted thiophenes with a wide variety of side-chain substituents as compounds of potential therapeutic interest. The thiophenes are prepared by reaction of a substrate-bound primary or secondary amine with a thiophosgene equivalent and reaction of the resulting intermediate with an acceptor-substituted acetonitrile in the presence of a base. Alkylation with an appropriate alkyl halide, followed by Thorpe-Ziegler-cyclization yields differently substituted, support-bound 3-aminothiophenes. These may be screened on the substrate or cleaved from the substrate and then screened in solution. Alternatively, the resin-bound 3-amino thiophenes or the synthetic intermediates can be subjected to further synthetic transformations (N-acylation, reduction) on the support, which permits the preparation of further therapeutically interesting compounds. The efficient synthesis of a wide variety of thiophenes using automated synthesis technology of the present method makes these compounds attractive candidates for the generation and rapid screening of diverse thiophene-based libraries. The method disclosed here provides an easy and fast access to highly diverse heterocyclic compounds of therapeutic interest, amenable to automatization.

专利号:WO-9740025-A1
优先权日:1996-04-19
标 题 :Solid phase and combinatorial synthesis of substituted 1,2,3-triazoles and of arrays of substituted 1,2,3-triazoles
发明人：DOERWALD FLORENCIO ZARAGOZA
权利人:NOVO NORDISK AS; DOERWALD FLORENCIO ZARAGOZA
摘要:A solid phase method for the synthesis of a plurality of differently substituted 1,2,3-triazoles with a wide variety of side-chain substituents as compounds of potential therapeutic interest. The 1,2,3-triazoles are prepared by acylation of a substrate-bound primary or secondary amine with a 3-oxoalkanoic acid and reaction of the resulting amide with a primary amine under dehydrating conditions to give an enamine. Treatment of this substrate-bound enamine with a sulfonyl azide in the presence of a base gives the corresponding 1,2,3-triazoles. These may be screened on the substrate or cleaved from the substrate and then screened in solution. The efficient synthesis of a wide variety of 1,2,3-triazoles using automated synthesis technology of the present method makes these compounds attractive candidates for the generation and rapid screening of diverse triazole-based libraries. The method disclosed here provides an easy and fast access to highly diverse heterocyclic compounds of therapeutic interest, amenable to automatization.

专利号:US-6136984-A
优先权日:1996-04-22
标 题 :Solid phase and combinatorial synthesis of substituted thiophenes and of arrays of substituted thiophenes
发明人：DOERWALD FLORENCIO ZARAGOZA
权利人:NOVO NORDISK AS
摘要:A solid phase method for the synthesis of a plurality of differently substituted thiophenes with a wide variety of side-chain substituents as compounds of potential therapeutic interest is disclosed. The thiophenes are prepared by acylation of a substrate-bound primary or secondary amine with cyanoacetic acid and reaction of the resulting cyanoacetamide with an isothiocyanate in the presence of a base. Alkylation with an appropriate alkyl halide, followed by Thorpe-Ziegier-cyclization yields differently substituted, support-bound 3-aminothiophenes. These may be screened on the substrate or cleaved from the substrate and then screened in solution. Alternatively, the resin-bound 3-amino thiophenes or the synthetic intermediates can be subjected to further synthetic transformations (N-acylation, reduction) on the support, which permits the preparation of further therapeutically interesting compounds. The efficient synthesis of a wide variety of thiophenes using automated synthesis technology of the present method makes these compounds attractive candidates for the generation and rapid screening of diverse thiophene-based libraries. The method disclosed here provides an easy and fast access to highly diverse heterocyclic compounds of therapeutic interest, amenable to automatization.

专利号:US-5847150-A
优先权日:1996-04-24
标题 :Solid phase and combinatorial synthesis of substituted 2-methylene-2, 3-dihydrothiazoles and of arrays of substituted 2-methylene-2, 3-dihydrothiazoles
发明人：DORWALD FLORENCIO ZARAGOZA
权利人:NOVO NORDISK AS
摘要:A solid phase method for the synthesis of a plurality of differently substituted 2-methylenethiazoles with a wide variety of side-chain substituents as compounds of potential therapeutic interest. The 2-methylenethiazoles are prepared by acylation of a substrate-bound primary or secondary amine with cyanoacetic acid and reaction of the resulting cyanoacetamide with an isothiocyanate in the presence of a base. Alkylation with an appropriate alkyl halide under acidic conditions yields differently substituted, support-bound 2-methylene-2,3-dihydrothiazoles. These may be screened on the substrate or cleaved from the substrate and then screened in solution. The efficient synthesis of a wide variety of 2-methylenethiazoles using automated synthesis technology of the present method makes these compounds attractive candidates for the generation and rapid screening of diverse thiazole-based libraries. The method disclosed here provides an easy and fast access to highly diverse heterocyclic compounds of therapeutic interest, amenable to automatization.

专利号:US-11738328-B2
优先权日:2021-04-30
标题:Single-step synthesis of chemisorption fiber sorbents (CHEFS) for the capture of CO2 and removal of water contaminants
发明人：GRAY MCMAHAN L; SHI FAN; YI SHOULIANG; WILFONG WALTER CHRIS; WANG QIUMING
权利人:US ENERGY
摘要:One or more embodiments relates to method for generating CHEFS having the steps of generating the CHEFS from a dope. One or more embodiments relates to a method for generating CHEFS having amine functional groups having the steps of generating a dope containing a BIAS with amine groups, at least one polymer, and at least one solvent; and forming CHEFS from the dope, wherein the generated CHEFS have no more than 30% amine loss compared to the BIAS.

专利号:US-6689919-B1
优先权日:1999-09-22
标 题 :Catalysts for oxidative polymerization of fluorophenol, method of oxidative polymerization of fluorophenol, and poly(oxyfluorophenylene) derivative
发明人：TSUCHIDA EISHUN; OYAIZU KENICHI; KUMAKI YOSUKE; SAITO KEI
权利人:JAPAN SCIENCE & TECH CORP
摘要:The synthesis of fluoropolyarylene ether with a high degree of polymerization is enabled, by using a copper complex catalyst with an oxidation potential in the range of -1V to 2V, for the oxidative polymerization of fluorophenols that contain at least one hydrogen atom as well as a fluorine atom bonded to the carbon atoms constituting the benzene ring.