专利号:US-8372881-B2 优先权日:2005-06-20 标题 :Acyloxyalkyl carbamate prodrugs of tranexamic acid, methods of synthesis and use 发明人:ZERANGUE NOA; JANDELEIT BERND; LI YUNXIAO; GALLOP MARK A 权利人:XENOPORT INC; ZERANGUE NOA; JANDELEIT BERND; LI YUNXIAO; GALLOP MARK A 摘要:Acyloxyalkyl carbamate prodrugs of trans-4-(aminomethyl)-cyclohexanecarboxylic acid, pharmaceutical compositions thereof, methods of making prodrugs of trans-4-(aminomethyl)-cyclohexane-carboxylic acid, and methods of using prodrugs of trans-4-(aminomethyl)-cyclohexanecarboxylic acid and pharmaceutical compositions thereof to treat or prevent various diseases or disorders are disclosed. Acyloxyalkyl carbamate prodrugs of trans-4-(aminomethyl)-cyclohexanecarboxylic acid and pharmaceutical compositions thereof suitable for oral and topical administration and for administration using sustained release dosage forms are also disclosed.
专利号:US-7777070-B2 优先权日:2005-06-20 标题:Acyloxyalkyl carbamate prodrugs of tranexamic acid, methods of synthesis and use
专利号:CA-2612292-A1 优先权日:2005-06-20 标 题 :Acyloxyalkyl carbamate prodrugs of tranexamic acid, methods of synthesis and use
专利号:CA-2612292-C 优先权日:2005-06-20 标 题:Acyloxyalkyl carbamate prodrugs of tranexamic acid, methods of synthesis and use
专利号:US-2011009483-A1 优先权日:2005-06-20 标 题 :Acyloxyalkyl carbamate prodrugs of tranexamic acid, methods of synthesis and use
专利号:JP-2008546717-A 优先权日:2005-06-20 标题:Acyloxyalkyl carbamate prodrugs of tranexamic acid, methods of synthesis, and uses
1: Drugs and Lactation Database (LactMed®) [Internet]. Bethesda (MD): National Institute of Child Health and Human Development; 2006–. Pamidronate. 2025 Jul 15. 168(3):191-199. doi: 10.5507/bp.2024.007. Epub 2024 Apr 27. 3:26330040211070298. doi: 10.1177/26330040211070298. 4: Brance ML, Cóccaro NM, Roitman P, Castiglioni A, Agostinis F, Spense M, Scheitlin B, Rene N, Brun LR. Pseudomyogenic hemangioendothelioma with bone and soft tissue involvement with favorable response to pamidronate: a case report and systematic review of the literature. Arch Osteoporos. 2022 Feb 1;17(1):28. doi: 10.1007/s11657-022-01062-4. 10(11):11950-11959. doi: 10.21037/apm-21-3056. A Leiden historical perspective. Bone. 2020 May;134:115244. doi: 10.1016/j.bone.2020.115244. Epub 2020 Jan 17. 27(3):240-249. doi: 10.1111/jopr.12571. Epub 2016 Nov 21. 94(42):e1822. doi: 10.1097/MD.0000000000001822.
合成参考文献
摘要:Australian and New Zealand Journal of Medicine., 27(719), 1997 []