CAS: 1072-86-2; (1R,2R)-Cyclohexane-1,2-Diol

该化合物是一个双环有机化合物,其特征是附属于环环的两组氢氧基(-OH)化合物,这种化合物以跨形形式存在,意即氢氧基组位于环的对面,影响其立体化学和物理特性,通常无色至黄色液体或固体,视温度而定,并因水中存在可溶性相对较高而闻名,因为氢氧基组可以结合氢,该化合物被用于各种用途,包括作为有机合成和生产药品和农用化学品中的阳性建筑块,其立体化学成有助于其在生物系统中的再活性和相互作用,使其对药用化学具有兴趣,应参考安全数据,以便处理任何化学物质,确保采取适当的预防措施.

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CAS号110-83-8 环己烯 | CAS号286-20-4 环氧环己烷 | CAS号1460-57-7 反式-1,2-环己二醇 | CAS号98-88-4 苯甲酰氯 | CAS号85761-38-2 Cyclohexanol, 2... | CAS号533-60-8 2-羟基环己酮 | CAS号13858-62-3 acetic acid,(1R... | CAS号765-87-7 1,2-环己二酮 | CAS号533-60-8 2-羟基环己酮 | CAS号21064-48-2 8,9,10,11-tetra... | CAS号627-93-0 己二酸二甲酯 | CAS号765-87-7 1,2-环己二酮 | CAS号1072-21-5 己二醛 | CAS号13858-62-3 acetic acid,(1R... | CAS号124-04-9 己二酸 | CAS号188241-97-6 benzoic acid,(1... | CAS号108-93-0 环己醇

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    专利信息


    专利号:US-2004049049-A1
    优先权日:2002-06-14
    标 题 :Stereoselective synthesis of 1,2-disubstituted cycloalkyls
    发明人:JURAYJ JURJUS F; FARHAN EMILE; SHARMA PRADEEP K
    权利人:JOHNSON MATTHEY PHARMACEUTICAL
    摘要:A stereoselectively method of preparing a 1,2-disubstituted cycloalkyl, such as aminocycloalkyl ether compounds, from a trans-1,2-disubstituted cycloalkyl or a cis-2-substituted cycloalkanol. For example, a stereoselective method of preparing 1R-(3R-hydroxypyrrolidin-1-yl)-2R-(2-phenylethoxy)-cyclohexane from 1R,2R-cyclohexanediol or from meso-cis-1,2-cyclohexanediol is described. Aminocycloalkyl ethers, such as 1R-(3R-hydroxypyrrolidin-1-yl)-2R-(2-phenylethoxy)-cyclohexane, can be used to treat cardiac disease.

    专利号:US-8487094-B2
    优先权日:2008-07-25
    标题 :Synthesis of inhibitors of 11β-hydroxysteroid dehydrogenase type 1
    发明人:FANDRICK KEITH R; GAO JOE JU; LI WENJIE; LU ZHI-HUI; ZHANG YONGDA
    权利人:FANDRICK KEITH R; GAO JOE JU; LI WENJIE; LU ZHI-HUI; ZHANG YONGDA; BOEHRINGER INGELHEIM INT
    摘要:Disclosed are syntheses of 11β-HSD1 inhibitors and corresponding intermediates that are promising for the treatment of a variety of disease states including diabetes, metabolic syndrome, obesity, glucose intolerance, insulin resistance, hyperglycemia, hypertension, hypertension-related cardiovascular disorders, hyperlipidemia, deleterious gluco-corticoid effects on neuronal function (e.g. cognitive impairment, dementia, and/or depression), elevated intra-ocular pressure, various forms of bone disease (e.g., osteoporosis), tuberculosis, leprosy (Hansen's disease), psoriasis, and impaired wound healing (e.g., in patients that exhibit impaired glucose tolerance and/or type 2 diabetes).

    专利号:US-12252583-B2
    优先权日:2018-06-20
    标题:Method of making mixture of polymers
    发明人:FONTANA GIOVANNI; GALIMBERTI MARCO; TORTELLI VITO
    权利人:SOLVAY SPECIALTY POLYMERS IT
    摘要:The present invention relates to a process for the synthesis of partially and fully fluorinated polyether (PFPE) polymers comprising cyclic moieties in the backbone chain, to PFPE polymers obtained therefrom and to the use of said PFPE polymers as intermediate compounds for the manufacture of additives for plastic and glass coating.

    专利号:EP-0725144-A1
    优先权日:1995-02-06
    标题 :Process for the preparation of glycosides using glycosidases from ciliates
    发明人:KIY THOMAS DR; HOERSCH BRIGITTE DR; MARQUARDT RUEDIGER DR
    权利人:HOECHST AG
    摘要:The invention relates to a process for the production of glycosides by enzymatic glycosylation by means of α- and β-glycosidases from holotrich ciliates and in particular from Hymenostomatida.n n n Glycosidases from holotrich ciliates are very well suited for the enzymatic synthesis of alkyl glycosides, glycopeptides, di- or oligosaccharides. Preferred glycosyldoren are nitrophenylglycosides, glycosyl fluorides or disaccharides, preferred acceptors are short-chain alcohols, polyhydroxy compounds, in particular monosaccharides, or protected hydroxyamino acids or corresponding peptides.

    专利号:US-9051656-B2
    优先权日:2009-07-23
    标题 :Electrochemical synthesis of aryl-alkyl surfacant precursor
    发明人:BHAVARAJU SAI; KARANJIKAR MUKUND; CHITTA PALLAVI
    权利人:BHAVARAJU SAI; KARANJIKAR MUKUND; CHITTA PALLAVI; CERAMATEC INC
    摘要:An aryl-alkyl (R—Ar) hydrocarbon is prepared by an electrosynthesis process in an electrolytic cell having an alkali ion conductive membrane positioned between an anolyte compartment configured with an anode and a catholyte compartment configured with a cathode. An anolyte solution containing an alkali metal salt of an alkyl carboxylic acid and an aryl compound is introduced into the anolyte compartment. The aryl compound may include an alkali metal salt of an aryl carboxylic acid, an arene (aromatic) hydrocarbon, or an aryl alkali metal adduct (Ar − M + ). The anolyte solution undergoes electrolytic decarboxylation to form an alkyl radical. The alkyl radical reacts with the aryl compound to produce the aryl-alkyl hydrocarbon.

    专利号:WO-2016142952-A1
    优先权日:2015-03-10
    标 题:Process for preparation of vilazodone and its novel intermediates
    发明人:BHEMIREDDY SATYANARAYANA REDDY; YARAPATHI VENKAT REDDY; PAIDIMARLA V VARA PRASADA REDDY
    权利人:NOSCH LABS PRIVATE LTD
    摘要:The invention relates to process for preparation of Vilazodone and novel intermediates for synthesis of Vilazodone.

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    合成参考文献


    摘要:Chciuk, T. V.; Flowers, R. A.; Flowers, R. A., Science of Synthesis Knowledge Updates, (2016) 2, 228.
    摘要:Vashchenko, B. V.; Grygorenko, O. O., Science of Synthesis Knowledge Updates, (2021) 3, 329.
    摘要:Smith, A. D.; Woods, P. A., Science of Synthesis: Asymmetric Organocatalysis, (2012) 1, 561.
    摘要:Johnson, J. B., Science of Synthesis: Stereoselective Synthesis, (2011) 3, 760.
    摘要:Bertau, M.; Jeromin, G. E., Science of Synthesis: Biocatalysis in Organic Synthesis, (2015) 1, 164.
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