专利号:US-2004049049-A1 优先权日:2002-06-14 标 题 :Stereoselective synthesis of 1,2-disubstituted cycloalkyls 发明人:JURAYJ JURJUS F; FARHAN EMILE; SHARMA PRADEEP K 权利人:JOHNSON MATTHEY PHARMACEUTICAL 摘要:A stereoselectively method of preparing a 1,2-disubstituted cycloalkyl, such as aminocycloalkyl ether compounds, from a trans-1,2-disubstituted cycloalkyl or a cis-2-substituted cycloalkanol. For example, a stereoselective method of preparing 1R-(3R-hydroxypyrrolidin-1-yl)-2R-(2-phenylethoxy)-cyclohexane from 1R,2R-cyclohexanediol or from meso-cis-1,2-cyclohexanediol is described. Aminocycloalkyl ethers, such as 1R-(3R-hydroxypyrrolidin-1-yl)-2R-(2-phenylethoxy)-cyclohexane, can be used to treat cardiac disease.
专利号:US-8487094-B2 优先权日:2008-07-25 标题 :Synthesis of inhibitors of 11β-hydroxysteroid dehydrogenase type 1 发明人:FANDRICK KEITH R; GAO JOE JU; LI WENJIE; LU ZHI-HUI; ZHANG YONGDA 权利人:FANDRICK KEITH R; GAO JOE JU; LI WENJIE; LU ZHI-HUI; ZHANG YONGDA; BOEHRINGER INGELHEIM INT 摘要:Disclosed are syntheses of 11β-HSD1 inhibitors and corresponding intermediates that are promising for the treatment of a variety of disease states including diabetes, metabolic syndrome, obesity, glucose intolerance, insulin resistance, hyperglycemia, hypertension, hypertension-related cardiovascular disorders, hyperlipidemia, deleterious gluco-corticoid effects on neuronal function (e.g. cognitive impairment, dementia, and/or depression), elevated intra-ocular pressure, various forms of bone disease (e.g., osteoporosis), tuberculosis, leprosy (Hansen's disease), psoriasis, and impaired wound healing (e.g., in patients that exhibit impaired glucose tolerance and/or type 2 diabetes).
专利号:US-12252583-B2 优先权日:2018-06-20 标题:Method of making mixture of polymers 发明人:FONTANA GIOVANNI; GALIMBERTI MARCO; TORTELLI VITO 权利人:SOLVAY SPECIALTY POLYMERS IT 摘要:The present invention relates to a process for the synthesis of partially and fully fluorinated polyether (PFPE) polymers comprising cyclic moieties in the backbone chain, to PFPE polymers obtained therefrom and to the use of said PFPE polymers as intermediate compounds for the manufacture of additives for plastic and glass coating.
专利号:EP-0725144-A1 优先权日:1995-02-06 标题 :Process for the preparation of glycosides using glycosidases from ciliates 发明人:KIY THOMAS DR; HOERSCH BRIGITTE DR; MARQUARDT RUEDIGER DR 权利人:HOECHST AG 摘要:The invention relates to a process for the production of glycosides by enzymatic glycosylation by means of α- and β-glycosidases from holotrich ciliates and in particular from Hymenostomatida.n n n Glycosidases from holotrich ciliates are very well suited for the enzymatic synthesis of alkyl glycosides, glycopeptides, di- or oligosaccharides. Preferred glycosyldoren are nitrophenylglycosides, glycosyl fluorides or disaccharides, preferred acceptors are short-chain alcohols, polyhydroxy compounds, in particular monosaccharides, or protected hydroxyamino acids or corresponding peptides.
专利号:US-9051656-B2 优先权日:2009-07-23 标题 :Electrochemical synthesis of aryl-alkyl surfacant precursor 发明人:BHAVARAJU SAI; KARANJIKAR MUKUND; CHITTA PALLAVI 权利人:BHAVARAJU SAI; KARANJIKAR MUKUND; CHITTA PALLAVI; CERAMATEC INC 摘要:An aryl-alkyl (R—Ar) hydrocarbon is prepared by an electrosynthesis process in an electrolytic cell having an alkali ion conductive membrane positioned between an anolyte compartment configured with an anode and a catholyte compartment configured with a cathode. An anolyte solution containing an alkali metal salt of an alkyl carboxylic acid and an aryl compound is introduced into the anolyte compartment. The aryl compound may include an alkali metal salt of an aryl carboxylic acid, an arene (aromatic) hydrocarbon, or an aryl alkali metal adduct (Ar − M + ). The anolyte solution undergoes electrolytic decarboxylation to form an alkyl radical. The alkyl radical reacts with the aryl compound to produce the aryl-alkyl hydrocarbon.
专利号:WO-2016142952-A1 优先权日:2015-03-10 标 题:Process for preparation of vilazodone and its novel intermediates 发明人:BHEMIREDDY SATYANARAYANA REDDY; YARAPATHI VENKAT REDDY; PAIDIMARLA V VARA PRASADA REDDY 权利人:NOSCH LABS PRIVATE LTD 摘要:The invention relates to process for preparation of Vilazodone and novel intermediates for synthesis of Vilazodone.
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