CAS: 93249-44-6; 2-Fluoro-5-Methylbenzaldehyde

上下游产品

CAS号352-32-9 对氟甲苯 | CAS号4885-02-3 1,1-二氯甲醚 | CAS号6280-45-1 9H-Xanthen-9-on...

对氟甲苯,1,1-二氯甲醚置于aluminum (Iii) Chloride体系中,用 二氯甲烷 作为反应溶剂,化学反应 2.08H,反应生成 2-氟-5-甲基苯甲醛,5-氟-2-甲基苯甲醛
参考文献:含氟芳烃与二氯甲基烷基醚的直接甲酰化.
标题:含氟芳烃与二氯甲基烷基醚的直接甲酰化.
摘要:研发了含氟芳族化合物与二氯甲基烷基醚的甲酰化.已经将二氯甲基丙基醚和二氯甲基丁基醚用于含氟的甲磺酸酯的甲酰化,以非常好的收率获得产物相应的醛.这些醚的使用要比由挥发性甲酸甲酯制得的甲基醚要好.含氟苯酚与这些二氯甲基烷基醚的反应未得到水杨醛衍生物,而是导致了相应的芳基甲酸酯的高收率.讨论了一个合理的机制.
DOI:10.1248/cpb.C19-00176

专利信息

专利号:US-11801251-B2
优先权日:2015-11-03
标 题 :Selective HDAC8 inhibitors and their uses
发明人：MEYER-ALMES FRANZ-JOSEF; MEYNERS CHRISTIAN; KLEINSCHEK ALEXANDER; HAUS PATRICIA
权利人:HOCHSCHULE DARMSTADT
摘要:The present invention relates to small molecule compounds based on benzopyrimido- or benzoimidazo-thiazin-imine as well as their (synthesis) intermediates and their use as HDAC inhibitors, in particular HDAC8 inhibitors. The present invention also relates to the use of said compounds in the treatment of cancer and as therapeutic agents for eukaryotic parasites and respective methods of treatment.

专利号:US-12344607-B2
优先权日:2018-10-29
标 题:Substituted 5,6,7,8-tetrahydropyrido[2,3-d]pyrimidine-2,4-diones for treating cardiac diseases
发明人：GRILLO MARK; KANE BRIAN; OSLOB JOHAN; ZHONG MIN; THOMPSON FABIENNE
权利人:MYOKARDIA INC
摘要:The present disclosure provides novel tetrahydropyran (THP)-substituted bicyclic pyrimidinedione compounds, including (6S,7S)-6-fluoro-7-(2-fluoro-5-methylphenyl)-3-(tetrahydro-2H-pyran-4-yl)-5,6,7,8-tetrahydropyrido[2,3-d]pyrimidine-2,4(1H,3H)-dione (shown below), that are useful for the treatment of hypertrophic cardiomyopathy (HCM), conditions associated with left ventricular hypertrophy, conditions associated with diastolic dysfunction, and/or symptoms associated thereof. The synthesis and characterization of the compounds is described, as well as methods for treating HCM and other forms of heart disease.