CAS: 84845-57-8; Ritipenem (Fce 22101)

上下游产品

22891[14C]-FCE22891 (5R,6S)-6-[(R)-1-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-3-carbamoyloxymethyl-7-oxo-4-thia-1-aza-bicyclo[3.2.0]hept-2-ene-2-carboxylic acid acetoxymethyl ester

📜Acetyloxymethyl (5R,6S)-6-[(1R)-1-[tert-Butyl(Dimethyl)Silyl]Oxyethyl]-3-(Carbamoyloxymethyl)-7-Oxo-4-Thia-1-Azabicyclo[3.2.0]Hept-2-Ene-2-Carboxylate置于phosphate Buffer,四丁基氟化铵体系中,用 四氢呋喃,溶剂黄146 作为反应溶剂,化学反应生成 利替培南
参考文献:The Total Synthesis Of Ritipenems. Construction Of Penem Thiazoline Ring By Incorporation Of Two 2C Units Of Glycolic Acid.
标题:The Total Synthesis Of Ritipenems. Construction Of Penem Thiazoline Ring By Incorporation Of Two 2C Units Of Glycolic Acid.
摘要:Short Syntheses Of Ritipenem Acoxyl 1A And Ritipenem 1B Are Reported. The Syntheses Start From (R)-4-Acetoxy-(S)-3-[(R)-1-(T-Butyldimethylsilyloxy)Ethyl]Azetidin-2-One 3 And Are Based On The Incorporation Of Two 2C Units Obtained By Manipulation Of Glicolyc Acid 4.
DOI:10.1016/s0040-4039(00)79192-1

专利信息

专利号:US-2009111737-A1
优先权日:1999-05-24
标题:Novel antibacterial agents
发明人：CHRISTENSEN BURTON G; MORAN EDMUND J; GRIFFIN JOHN H; JUDICE J KEVIN; MU YONGQI; PACE JOHN L; MAMMEN MATHAI; AGGEN JAMES
权利人:CHRISTENSEN BURTON G; MORAN EDMUND J; GRIFFIN JOHN H; JUDICE J KEVIN; MU YONGQI; PACE JOHN L; MAMMEN MATHAI; AGGEN JAMES
摘要:This invention relates to novel multibinding compounds (agents) that are antibacterial agents. The multibinding compounds of the invention comprise from 2-10 ligands covalently connected by a linker or linkers, wherein each of said ligands in their monovalent (i.e., unlinked) state have the ability to bind to a an enzyme involved in cell wall biosynthesis and metabolism, a precursor used in the synthesis of the bacterial cell wall and/or the bacterial cell surface thereby interfere with the synthesis and/or metabolism of the cell wall. In particular the multibinding compounds of the invention comprise from 2-10 ligands covalently connected by a linker or linkers, wherein each of said ligands hasn a ligand domain capable of binding to penicillin binding proteins, a transpeptidase enzyme, a substrate of a transpeptidase enzyme, a beta-lactamase enzyme, pencillinase enzyme, cephalosporinase enzyme, a transglycoslase enzyme, or a transglycosylase enzyme substrate; Preferably, the ligands are selected from the beta lactam or glycopeptide class of antibacterial agents.

专利号:US-2014315720-A1
优先权日:2012-10-24
标 题 :Polysaccharide ester microspheres and methods and articles relating thereto
发明人：FALLON DENIS G; GARRETT THOMAS S; KIZER LAWTON E; ZAZZARA KAREN L; COMBS MICHAEL T; JOHNSON RICHARD K; DEHART GARY
权利人:CELANESE ACETATE LLC
摘要:A method for producing a polysaccharide ester microsphere may include forming a polysaccharide ester product from a polysaccharide synthesis, wherein the polysaccharide ester product comprises a polysaccharide ester and a solvent; diluting the polysaccharide ester product, thereby yielding a polysaccharide ester dope; and forming a plurality of polysaccharide ester microspheres from the polysaccharide ester dope. Suitable polysaccharides may include, but are not limited to, starch, cellulose, hemicellulose, algenates, chitosan, and any combination thereof. Esters thereof may be organic esters (e.g., acetate and the like), inorganic esters (e.g., sulfonates and the like), or combinations thereof. Further, the solids conent of the polysaccharide ester dope, in some instances, may be greater than about 16 wt %.

专利号:US-4508649-A
优先权日:1981-12-11
标题 :Process for preparing optically active penems
发明人：ALPEGIANI MARCO; BATTISTINI CARLO; BEDESCHI ANGELO; FRANCESCHI GIOVANNI; FOGLIO MAURIZIO; ZARINI FRANCO
权利人:ERBA FARMITALIA
摘要:Processes for the preparation of a penem derivative of formula I ##STR1## wherein n=0 or 1; R is a carboxy protecting group or H; n R 1 is hydrogen, a hydrocarbon group substituted or unsubstituted, or lower alkoxy; and n R 2 is hydrogen, C 1 -C 5 alkyl, carbamoyl N-substituted by lower alkyl or unsubstituted, or an acyl group; n and the pharmaceutically acceptable salts thereof. n These processes allow one to prepare stereospecifically only 5R derivatives, and are characterized by R 2 -introduction at a very late stage in the synthesis, thereby enabling a great number of compounds of formula I to be prepared. n Penem derivatives are useful antibacterial agents.

专利号:NZ-505979-A
优先权日:1998-06-08
标 题 :Multibinding antibacterial agents comprising 2 antibiotic or aglycone ligands, connected by a linker, capable of affecting cell wall synthesis or metabolism

专利号:CN-102268024-A
优先权日:2011-06-10
标 题 :New crystal form of biapenem and its synthesis method