CAS: 70264-94-7; Methyl 4-(Bromomethyl)-3-Methoxybenzoate

上下游产品

CAS号3556-83-0 3-甲氧基-4-甲基苯甲酸甲 | CAS号34241-39-9 2-(2-cyanopropa... | CAS号7151-68-0 3-甲氧基-4-甲基苯甲酸 | CAS号107786-78-7 cyclopentyl N-[... | CAS号107754-14-3 4-(5-Amino-1-me... | CAS号193964-75-9 Methyl 3-methox... | CAS号107754-20-1 4-(5-环戊酰基氨基-1-甲... | CAS号107753-78-6 扎鲁司特 | CAS号1159195-67-1 Methyl 3-[2-Met... | CAS号1160235-24-4

3-甲氧基-4-甲基苯甲酸置于n-溴代丁二酰亚胺(Nbs),氯化亚砜,偶氮二异丁腈体系中,用 氯仿 作为反应溶剂,化学反应生成 4-溴甲基-3-甲氧基苯甲酸甲酯
参考文献:通过设计多药理学提高扎鲁鲁司特的抗炎能力
标题:通过设计多药理学提高扎鲁鲁司特的抗炎能力
摘要:多靶点设计可提供具有潜在优势的功效和安全性的生物活性小分子.特别是多因素慢性炎症性疾病,需要多种药理干预措施才能稳定治疗.通过微小的结构变化,我们开发了半胱氨酰-白三烯受体拮抗剂扎鲁司特的紧密类似物,其同时抑制可溶性环氧化物水解酶并激活过氧化物酶体增殖物激活的受体γ.三重调节剂在体内表现出强大的抗炎活性,并突出了设计的多靶点药物的治疗潜力.
DOI:10.1021/acs.Jmedchem.8B00458

专利信息

专利号:US-9919064-B2
优先权日:2012-08-10
标 题 :Compositions, methods, and systems for the synthesis and use of imaging agents
发明人：CESATI RICHARD R; RADEKE HEIKE S; PANDEY SURESH K; PUROHIT AJAY; ROBINSON SIMON P
权利人:LANTHEUS MEDICAL IMAGING INC
摘要:The present invention provides compounds with imaging moieties for imaging a subject. The present invention also relates to systems, compositions, and methods for the synthesis and use of imaging agents, or precursors thereof. An imaging agent precursor may be converted to an imaging agent using the methods described herein. In some cases, a composition or plurality of imaging agents is enriched in 18 F. In some cases, an imaging agent may be used to image an area of interest in a subject, including, but not limited to, the heart, cardiovascular system, cardiac vessels, brain, and other organs.

专利号:US-2007031854-A1
优先权日:1999-02-01
标题:Novel 10,10'-substituted-9,9'-biacridilidine luminescent molecules their preparation and uses
发明人：KATSILOMETES GEORGE W
权利人:KATSILOMETES GEORGE W
摘要:Novel symmetric, uniformly symmetric and asymmetric 10,10′-substituted-9,9′-biacridines and the synthesis of such symmetric, uniformly symmetric and asymmetric 10,10′-substituted-9,9′-biacridine molecules and their derivatives is disclosed. These molecules are shown to produce light by luminescence in the presence of signals. These symmetric, uniformly symmetric or asymmetric 10,10′-substituted-9,9′-biacridines are used alone or attached to haptens or macromolecules and are utilized as labels in the preparation of iluminescent homogeneous and heterogeneous assays. They are also used in conjunction with other label molecules to produce multiple analyte assays.

专利号:RU-2002740-C1
优先权日:1989-12-11
标题 :3-methoxy-4-[1-methyl-5-(2-methyl-4,4,4- trifluorobutylcarbamoyl) indole-3-yl- -methyl]-n-(-methylphenylsulfonyl) benzamide or its pharmaceutically acceptable salt as leukotriene antagonists, and products for synthesis of theirs

专利号:US-2018318456-A1
优先权日:2012-08-10
标题:Compositions, methods, and systems for the synthesis and use of imaging agents

专利号:US-2020230264-A1
优先权日:2012-08-10
标 题 :Compositions, methods, and systems for the synthesis and use of imaging agents

专利号:WO-2014026079-A2
优先权日:2012-08-10
标题 :Compositions, methods, and systems of the synthesis and use of imaging agents