CAS: 6973-81-5; 2-Amino-6-Mercaptopyrimidin-4(1H)-One

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2-amino-6-chloro-4-pyrimidinol 2-Amino-6-[2-(4-bromo-phenyl)-2-oxo-ethylsulfanyl]-5H-pyrimidin-4-one (6R,7R)-7-Amino-3-(2-amino-6-hydroxy-pyrimidin-4-ylsulfanyl)-8-oxo-5-thia-1-aza-bicyclo[4.2.0]°Ct-2-ene-2-carboxylic acid benzhydryl ester (6R,7R)-3-{(E)-3-[(2-amino-6-hydroxy-4-pyrimidinyl)sulfanyl]-1-propenyl}-7-({2-[(2,5-dichlorophenyl)sulfanyl]acetyl}amino)-8-oxo-5-thia-1-azabicyclo[4.2.0]°Ct-2-ene-2-carboxylic acid methyl 4-[2-(2-amino-4-hydroxythieno[2,3-d]pyrimidine-5-yl)ethyl]benzoate

📜2-氨基-6-氯-4-羟基嘧啶置于sodium Hydrogen Sulfide体系中,用 乙二醇 作为反应溶剂,化学反应生成 2-氨基-6-巯基-4(1H)-嘧啶酮
参考文献:Structural Studies Of Pterin-Based Inhibitors Of Dihydropteroate Synthase
标题:Structural Studies Of Pterin-Based Inhibitors Of Dihydropteroate Synthase
摘要:Dihydropteroate Synthase (Dhps) Is A Key Enzyme In Bacterial Folate Synthesis And The Target Of The Sulfonamide Class Of Antibacterials. Resistance And Toxicities Associated With Sulfonamides Have Led To A Decrease In Their Clinical Use. Compounds That Bind To The Pterin Binding Site Of Dhps,As Opposed To The P-Amino Benzoic Acid (Paba) Binding Site Targeted By The Sulfonamide Agents,Arc Anticipated To Bypass Sulfonamide Resistance. To Identify Such Inhibitors And Map The Pterin Binding Pocket,We Have Performed Virtual Screening,Synthetic,And Structural Studies Using Bacillus Anthracis Dhps. Several Compounds With Inhibitory Activity Have Been Identified,And Crystal Structures Have Been Determined That Show How The Compounds Engage The Pterin Site. The Structural Studies Identify The Key Binding Elements And Have Been Used To Generate A Structure-Activity Based Pharmacophore Map That Will Facilitate The Development Of The Next Generation Or Dhps Inhibitors Which Specifically Target The Pterin Site.
DOI:10.1021/jm900861D