CAS: 63545-55-1; 3-(4-Mercaptophenyl)Propanoic Acid

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CAS号140-89-6 乙基黄原酸钾

专利信息

专利号:US-4950745-A
优先权日:1986-10-30
标 题:Process for synthesis of oligonucleotides and compound for forming polymeric protecting group
发明人：ISHIDO YOSHIHARU; KAMAIKE KAZUO
权利人:DAICEL CHEM
摘要:A chain-extended oligonucleotide is synthesized by condensing a mononucleotide, oligonucleotide, mononucleoside succinate or oligonucleotide succinate in which only the terminal 5'-hydroxyl group is not blocked and the other functional groups are blocked by a plurality of low-molecular-weight protecting groups and one polysaccharide derivative protecting group, with a mononucleotide or oligonucleotide in which the functional groups other than the terminal phosphoric acid group ar blocked by low-molecular-weight protecting groups in the homogeneous system in a common solvent. n A compound represented by the following formula is preferred as the compound forming the polysaccharide derivative protecting group: ##STR1## wherein C 6 H 7 O 2 stands for an anhydrous glucose residue, R stands for ##STR2## n is a number of 10 to 2,000, x is a number of 0.4 to 0.8, and y is a number of 1.0 to 2.0.