CAS: 53963-10-3; 2-(6-Bromohexyloxy)Tetrahydro-2H-Pyran

该化合物是一种溴化四氢丙烯衍生物,通常用作有机合成的中间体,其主要结构特征包括溴己烷链和四氢丙烯基保护组,使其对引入烷基功能或作为准备更复杂的分子的前体很有价值.THP组增强了稳定性和溶性,而终端溴则允许通过核分裂替代或交叉相交反应进一步发挥作用.这种化合物在制药和材料化学中特别有用,因为需要控制地将烷基或连接器结合.其定义明确的再活动特征可以确保多步合成路径的连续性能.

结构式图片

相似化合物

4286-55-9 31608-22-7 33821-94-2

上下游产品

CAS号110-87-2 3,4-二氢-2H-吡喃 | CAS号4286-55-9 6-溴正己醇 | CAS号28659-22-5 6-((tetrahydro-... | CAS号629-11-8 1,6-己二醇 | CAS号2009-84-9 2-((6-氯己基)氧基)四氢... | CAS号142-68-7 四氢吡喃 | CAS号1110667-75-8 O-6-(tetrahydro... | CAS号2009-83-8 6-氯-1-己醇 | CAS号502-44-3 ε-己内酯 | CAS号25542-62-5 6-溴己酸乙酯 | CAS号5963-14-4 8-甲基壬酸 | CAS号184678-19-1 2-d°Cosoxyoxane | CAS号201601-60-7 4-[6-(oxan-2-yl... | CAS号33956-49-9 反式-8-反式-10-十二碳二烯-1-醇 | CAS号2430-95-7 (Z)-7-Tetradece... | CAS号82258-36-4 rac-Etomoxir | CAS号3208-25-1 7-苯基-1-庚醇 | CAS号28079-04-1 (Z)-8-十二烯基乙酸酯 | CAS号661-19-8 正二十二醇 | CAS号31772-06-2 1,18-二溴十八烷

合成工艺路线路线简述

    1,6-己二醇置于camphor-10-Sulfonic Acid,氢溴酸体系中,用 二氯甲烷,苯 作为反应溶剂,化学反应 0.5H,反应生成 2-(6-溴己氧基)四氢吡喃
    参考文献:磺酰基取代的三烯的分子内狄尔斯-阿尔德反应
    标题:磺酰基取代的三烯的分子内狄尔斯-阿尔德反应
    摘要:已经进行了一系列磺酰基取代的十-,十一-和十二碳烯的合成和分子内diels-Alder热反应.讨论了这些反应的立体选择性,并描述了双环产物的甲基化反应.
    DOI:10.1016/s0040-4020(01)96038-7

    海关参考信息

    专利信息


    专利号:US-2013190399-A1
    优先权日:2009-10-31
    标 题:Synthesis and use of omega-3 and omega 6 very long chain polyunsaturated fatty acids (VLC-PUFA)
    发明人:RAMAN KRISHNA; TARWADE VINOD
    权利人:RAMAN KRISHNA; TARWADE VINOD; MARTEK BIOSCIENCES CORP
    摘要:The invention provides methods of synthesizing omega-3 and omega-6 very long chain polyunsaturated fatty acids (VLC-PUFAs, C28-C42:4, 5 and 6), analogs and derivatives thereof, pharmaceutical compositions containing these isolated VLC-PUFA compounds and therapeutic uses therefor.

    专利号:WO-2011053892-A1
    优先权日:2009-10-31
    标 题:Synthesis and use of omega-3 and omega-6 very long chain polyunsaturated fatty acids (vlc-pufa)
    发明人:RAMAN KRISHNA; TARWADE VINOD; SALEM NORMAN JR
    权利人:MARTEK BIOSCIENCES CORP; RAMAN KRISHNA; TARWADE VINOD; SALEM NORMAN JR
    摘要:The invention provides methods of synthesizing omega-3 and omega-6 very long chain polyunsaturated fatty acids (VLC- PUFAs, C28-C42:4,5 and 6), analogs and derivatives thereof, pharmaceutical compositions containing these isolated VLC-PUFA compounds and therapeutic uses therefor.

    专利号:US-2016108436-A1
    优先权日:2014-05-16
    标题:Synthesis of olefinic alcohols via enzymatic terminal hydroxylation

    专利号:US-5728376-A
    优先权日:1995-04-25
    标题 :Tetradecatrienyl and tetradecadienyl acetates and their use as sex attractants for tomato pests
    发明人:ATTYGALLE ATHULA B; JHAM GULAB N; SVATOS ALES; FRIGHETTO ROSA T S
    权利人:CORNELL RES FOUNDATION INC
    摘要:The present invention is directed to compounds useful as moth attractants and to methods for controlling populations of the tomato moth Scrobipalpuloides absoluta with these compounds. The compounds are 3,8,11-tetradecatrienyl acetates, 3,8-tetradecadienyl acetates, 3,11-tetradecadienyl acetates, and 8,11-tetradecadienyl acetates. Preferred compounds are (3E,8Z,11Z)-3,8,11-tetradecatrienyl acetate, (3E,8Z)-3,8-tetradecadienyl acetate, (3E,11Z)-3,11 -tetradecadienyl acetate, and (8Z,11Z)-8-11-tetradecadienyl acetate. The compounds can be used as an attractant in moth traps comprising, in addition to the compounds, a moth restraint. Alternatively, the compounds of the present invention can be combined with a biocontrol agent or an insecticide for use as a moth control composition. Synthesis of (3E,8Z,11Z)-3,8,11-tetradecatrienyl acetate is described.

    专利号:US-2012123113-A1
    优先权日:2009-01-27
    标题:Di-substituted pyridinum polymers and synthesis thereof
    发明人:JASPARS MARCEL; HOUSSEN WAEL; LU ZHIBAO; SCOTT RODERICK; EDRADA-EBEL RUANGELIE; MANCINI INES
    权利人:JASPARS MARCEL; HOUSSEN WAEL; LU ZHIBAO; SCOTT RODERICK; EDRADA-EBEL RUANGELIE; MANCINI INES; UNIV ABERDEEN
    摘要:A method of producing a di-substituted pyridinium polymer by microwave-assisted polymerisation of a 2, 3, or 4-substituted pyridine monomer of the formula NC 5 R 4 —R′—X, wherein R is selected from hydrogen, hydroxyl, and substituted or unsubstituted alkyl, alkoxy, aryl, alkaryl, aralkyl, and alkenyl groups, R′ is a linking group, and X is a leaving group. Using this method, di-substituted pyridinium polymer compositions may be obtained wherein at least 50% of the di- substituted pyridinium polymer chains in the composition have the same degree of polymerisation.

    专利号:WO-2015176020-A1
    优先权日:2014-05-16
    标题 :Synthesis of olefinic alcohols via enzymatic terminal hydroxylation
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    主要参考文献

    [参考文献]: Ashot Khrimian, Et Al. Sex Pheromone Of Browntail Moth, Euproctis Chrysorrhea (L.): Synthesis And Field Deployment. J Agric Food Chem. 2008 Apr 9;56(7):2452-6.

    合成参考文献


    摘要:Wang, D.; Chan, T. H., Science of Synthesis, (2002) 4, 481.
    摘要:Podlech, J., Science of Synthesis, (2007) 25, 26.
    摘要:Braun, M., Science of Synthesis, (2007) 35, 318.
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