CAS: 522-00-9; Profenamine

英文名称Profenamine
中文名称乙丙嗪
IUPAC名称10H-Phenothiazine-10-ethanamine, N,N-diethyl-alpha-methyl-
其它别名Phenothiazine,10-[2-(diethylamino)propyl]- (8CI); Prophenamine (7CI); (?à)-Ethopropazine; (?à)-Profenamine; 10-(2-Diethylamino-1-propyl)phenothiazine; 10-(2-Diethylamino-2-methylethyl)phenothiazine; 10-(2-Diethylaminopropyl)phenothiazine; 2-Diethylamino-1-propyl-N-dibenzoparathiazine; Ethapropazine; Ethopromazine; Ethopropazine; Isopthazine; Isothazine; Isothiazine; N,N-Diethyl-1-(10H-phenothiazin-10-yl)-2-propanamine; Parkin; Parsidol; Phenopropazine; Profenamine
CAS编号522-00-9
MFCD编号:MFCD00242639
EINECS号:208-320-4
分子式:C19H24N2S分子量:312.47226
产品CID: 1512896
同类组份化合物CAS1094-08-2 (HCl)522-00-9 (free base)
产品分类原料药 → 神经系统用药 → 抗震颤麻痹药

相似结构搜索
InChIKey: CDOZDBSBBXSXLB-UHFFFAOYNA-N
1S/C19H24N2S/c1-4-20(5-2)15(3)14-21-16-10-6-8-12-18(16)22-19-13-9-7-11-17(19)21/h6-13,15H,4-5,14H2,1-3H3
计算化学: 氢键受体数3.0氢键供体数0.0可旋转键数5.0

物理性质

熔点53-55°
沸点430.1±34.0 °C at 760 mmHg
闪点213.9±25.7 °C
密度1.1±0.1 g/cm3
PSA:31.78
LogP:5.84
折射率1.599
蒸汽压0.0±1.0 mmHg at 25°C
溶解性0.693 mg/L
外观形态固体-粉末
储存条件-20°C
产品应用该化合物是一种苯并呋喃衍生物,用作抗巴金森毒剂,具有抗胆碱基,抗脑膜炎和抗肾上腺素作用.

MSDS等安全信息

合成工艺路线路线简述

📜盐酸普罗吩胺置于sodium Hydroxide体系中,用二氯甲烷作为反应溶剂,化学反应生成乙丙嗪
参考文献: Controlled Release Compositions And Methods For Using Same[fr] Compositions A Liberation Progressive Et Son Procede D'Utilisation
标题: Controlled Release Compositions And Methods For Using Same[fr] Compositions A Liberation Progressive Et Son Procede D'Utilisation

海关参考信息

2921211000-乙二胺
2921440000-二苯胺
2901100000-饱和无环烃
2930909099-其他有机硫化合物
💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
详情请参考：📖 海关编码查询和海关进出口税则

其他信息查阅

供应商参考报价(招募中)

品牌试剂参考报价(招募中)

实用工具

📌 第三方产品分析报告

✅ COA系统入驻 | 共享模式

主要参考文献

1: Estévez J, Selva V, Benabent M, Mangas I, Sogorb MÁ, Vilanova E. Acetylcholine-hydrolyzing activities in soluble brain fraction: Characterization with reversible and irreversible inhibitors. Chem Biol Interact. 2016 Nov 25;259(Pt B):374-381. doi: 10.1016/j.cbi.2016.08.004. Epub 2016 Aug 6. doi: 10.1007/s00204-016-1670-6. Epub 2016 Feb 2. doi: 10.1124/dmd.113.051805. Epub 2013 May 6. doi: 10.1111/vcp.12032. Epub 2013 Apr 1. doi: 10.1016/j.bbrc.2013.03.061. Epub 2013 Mar 27. doi: 10.1002/jat.2730. Epub 2012 Mar 12. doi: 10.1016/j.biochi.2011.06.023. Epub 2011 Jun 29. doi: 10.1177/1087057110372257. Epub 2010 Jun 14.
9: Yücel YY, Tacal O, Ozer I. Comparative effects of cationic triarylmethane, phenoxazine and phenothiazine dyes on horse serum butyrylcholinesterase. Arch Biochem Biophys. 2008 Oct 15;478(2):201-5. doi: 10.1016/j.abb.2008.07.006. Epub 2008 Jul 16. Epub 2007 Apr 13. Epub 2006 Dec 21.