CAS: 4873-09-0; Allyl 4-Methylbenzenesulfonate

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CAS号107-18-6 烯丙醇 | CAS号98-59-9 对甲苯磺酰氯(PTSC) | CAS号104-15-4 对甲苯磺酸 | CAS号106-95-6 烯丙基溴 | CAS号50626-34-1 5-bicyclo[2.2.1... | CAS号18146-00-4 三甲基烯丙氧基硅烷 | CAS号16722-51-3 4-toluene sulfonate | CAS号762-72-1 烯丙基三甲基硅烷 | CAS号16836-95-6 对甲苯磺酸银 | CAS号3698-28-0 2-烯丙基苯甲醚 | CAS号10577-44-3 (E/Z)-1-methoxy... | CAS号3354-58-3 2-烯丙基-6-甲基苯酚 | CAS号21574-35-6 4-allyl-2-methy... | CAS号32815-70-6 2-甲基-5-己烯-3-醇 | CAS号41274-09-3 (R)-对甲苯磺酸-1-甘油酯 | CAS号50765-70-3 (S)-1-对甲苯磺酰氧基-2... | CAS号557-31-3 烯丙基乙基醚 | CAS号1524-54-5 烯丙基2,2,2-三氟乙基醚 | CAS号107-18-6 烯丙醇

📜2-Hydroxymethyl-Bicyclo<2.2.1>Hept-5-En-P-Toluolsulfonat 600.0 °C,4.0 Pa 条件下,以79%的收率获得产物对甲苯磺酸烯丙酯
参考文献:含氟维氮氮杂环的环封闭复分解途径
标题:含氟维氮氮杂环的环封闭复分解途径
摘要:描述了高度官能化的氟化哌啶的合成.该合成中的关键步骤是涉及氟化物取代的烯烃的闭环复分解反应,这导致相应的环状氟乙烯.已经评估了几种到达不同取代的哌啶的序列.(©wiley-Vch Verlag Gmbh&co.Kgaa,69451 Weinheim,Germany,2006)
DOI:10.1002/ejoc.200500826

专利信息

专利号:US-2006287520-A1
优先权日:2005-05-16
标 题 :Synthesis of salinosporamide A and analogues thereof
发明人：DANISHEFSKY SAMUEL J; ENDO ATSUSHI
权利人:DANISHEFSKY SAMUEL J; ENDO ATSUSHI
摘要:A novel synthesis of salinosporamide A is provided. Salinospoamide A as well as structurally related natural products, omuralide and lactacystin, have been shown to be proteasome inhibitors. Therefore, these compounds as well as analogues of these natural products may be useful in the treatment of proliferative diseases such as cancer, autoimmune diseases, diabetic retinopathy, etc. The invention provides for the synthesis of salinosporamide A as well as analogs thereof using a convenient point for derivatization of the bicyclic core. Pharmaceutical compositions and method of using the inventive compounds are also provided.

专利号:US-8461357-B2
优先权日:2008-09-19
标题 :Expeditious synthesis of gibberellin A5 and esters thereof
发明人：FAIRWEATHER KELLY A; MANDER LEWIS N; PHARIS RICHARD P
权利人:FAIRWEATHER KELLY A; MANDER LEWIS N; PHARIS R P; UTI LIMITED PARTNERSHIP
摘要:An expeditious synthesis of gibberellin A 5 (GA 5 ) esters is presented, from which GA 5 may be prepared. The synthesis offers an inexpensive route of few steps to these compounds, starting from gibberellin A 3 (GA 3 ) esters in the presence of a metal hydride.

专利号:US-2010069644-A1
优先权日:2008-09-15
标题:Method of regio-selective synthesis of tri-substituted-1, 2, 3-triazoles
发明人：SHI XIAODONG
权利人:SHI XIAODONG
摘要:The embodiments provide for region-selective synthesis of tri-substituted 1,2,3-traizoles. A first embodiment provides for the selective N-2 alkylation of a 4,5-disubstituted 1,2,3-triazole. A second embodiment provides for the selective acetylation of a 4,5-disubstituted 1,2,3-triazole. A third embodiment provides for the selective arylation of a 4,5-disubstituted 1,2,3-triazole.

专利号:WO-2024137329-A1
优先权日:2022-12-20
标 题:Methods for the synthesis of complement factor d inhibitors and intermediates thereof
发明人：HASHIMOTO AKIHIRO; TIPPARAJU SURESH KUMAR
权利人:ALEXION PHARMA INC
摘要:The present disclosure provides methods for the synthesis of complement factor D inhibitors and intermediates thereof.

专利号:US-2005043376-A1
优先权日:1996-12-03
标题:Synthesis of epothilones, intermediates thereto, analogues and uses thereof
发明人：DANISHEFSKY SAMUEL J; BERTINATO PETER; SU DAI-SHI; MENG DONGFANG; CHOU TING-CHAO; KAMENECKA TED; SORENSEN ERIK J; BALOG AARON; SAVIN KENNETH A
摘要:The present invention provides convergent processes for preparing epothilone A and B, desoxyepothilones A and B, and analogues thereof. Also provided are analogues related to epothilone A and B and intermediates useful for preparing same. The present invention further provides novel compositions based on analogues of the epothilones and methods for the treatment of cancer and cancer which has developed a multidrug-resistant phenotype.

专利号:US-4912253-A
优先权日:1988-06-06
标题 :Method for the preparation of an unsaturated alcohol or ester thereof
发明人：FUKUMOTO TAKEHIKO; YAMAMOTO AKIRA
权利人:SHINETSU CHEMICAL CO
摘要:An efficient method is proposed for the synthesis of an unsaturated alcohol of the general formula R--CHâ•?CH(CH 2 ) n+1 OH, in which R is a hydrogen atom or a monovalent hydrocarbon group having 1 to 10 carbon atoms and the subscript n is an integer in the range from 3 to 10, in which an acetate of the formula R--CHâ•?CHCH 2 OCOCH 3 is subjected to a coupling reaction with a Grignard reagent of the formula X 1 Mg(CH 2 ) n OMgX 2 , in which X 1 and X 2 are each a halogen atom, and then the reaction product is hydrolyzed. When the reaction product of the coupling reaction is reacted with acetic anhydride instead of hydrolysis, the corresponding acetate can readily be obtained. These unsaturated alcohols and acetates form a class of important biologically active compounds or intermediates thereof including sex pheromone compounds of insects.