CAS: 36629-42-2; Methyl Pentafluorobenzoate

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CAS号67-56-1 甲醇 | CAS号602-94-8 五氟苯甲酸 | CAS号2251-50-5 2,3,4,5,6-五氟苯甲酰氯 | CAS号108-24-7 乙酸酐 | CAS号879-06-1 3-indole acetamide | CAS号294187-76-1 4-(N-叔丁氧羰基氨基)四氟苯叠氮化物 | CAS号853-39-4 全氟二苯甲酮 | CAS号122590-77-6 4-叠氮基-2,3,5,6-四氟苯甲酸 | CAS号122590-75-4 4-叠氮基四氟苯甲酸甲酯 | CAS号126695-58-7 4-叠氮基-2,3,5,6-四... | CAS号294187-78-3 4-AZIDOTETRAFLU... | CAS号122590-78-7 4-azido-2,3,5,6... | CAS号715-37-7 4-氨基-2,3,5,6-四氟苯甲酸甲酯 | CAS号4707-12-4 methyl 2,3,5,6-...

1,2,3,4,5-五氟-6-(三甲氧基甲基)苯置于硫酸体系中,用 二氯甲烷 作为反应溶剂,化学反应生成 五氟苯甲酸甲酯
参考文献:Nucleophilic Aromatic Substitution With Dialkoxycarbenes
标题:Nucleophilic Aromatic Substitution With Dialkoxycarbenes
摘要:二甲氧基卡宾在110oc时通过2,2-二甲氧基-5,5-二甲基-δ3-1,3,4-氧化二唑的热解反应生成,可以从带有电子吸引基团的芳香环中取代氟.报道了sanger试剂和六氟苯上的分子间取代,以及带有烷基的芳基取代的分子内取代.关键词:芳香取代,芳基(二甲氧基)氟甲烷,芳基氟化物,二烷氧基卡宾,亲核取代.
DOI:10.1139/v97-159

专利信息

专利号:US-6503759-B1
优先权日:1992-10-01
标题 :Complex combinatorial chemical libraries encoded with tags
发明人：STILL W CLARK; OHLMEYER MICHAEL H J; DILLARD LAWRENCE W; READER JOHN C; WIGLER MICHAEL H
权利人:UNIV COLUMBIA; COLD SPRING HARBOR LAB
摘要:Encoded combinatorial chemistry is provided, where sequential synthetic schemes are recorded using organic molecules, which define choice of reactant, and stage, as the same or different bit of information. Various products can be produced in the multi-stage synthesis, such as oligomers and synthetic non-repetitive organic molecules. Conveniently, nested families of compounds can be employed as identifiers, where number and/or position of a substituent define the choice. Alternatively, detectable functionalities may be employed, such as radioisotopes, fluorescers, halogens, and the like, where presence and ratios of two different groups can be used to define stage or choice. Particularly, pluralities of identifiers may be used to provide a binary or higher code, so as to define a plurality of choices with only a few detachable tags. The particles may be screened for a characteristic of interest, particularly binding affinity, where the products may be detached from the particle or retained on the particle. The reaction history of the particles which are positive for the characteristic can be determined by the release of the tags and analysis to define the reaction history of the particle.

专利号:US-7196090-B2
优先权日:2002-07-25
标题 :Kinase inhibitors
发明人：CONNOLLY CLEO J CHIVIKAS; DEUR CHRISTOPHER JAMES; HAMBY JAMES MARINO; HOYER DENTON WADE; LIMBERAKIS CHRIS; REED JESSICA ELIZABETH; SCHROEDER MEL CONRAD; TAYLOR CLARKE
权利人:WARNER LAMBERT CO
摘要:This invention provides phenyl-substituted pyrimidopyrimidines, dihydropyrimido-pyrimidines, pyridopyrimidines, naphthyridines, and pyridopyrazines of the general formula: n nthat inhibit cyclin-dependent kinase and tyrosine kinase enzymes, methods and intermediate compounds for their synthesis, as well as pharmaceutical compositions and methods for their use in treating, inhibiting or preventing maladies associated with cell proliferative disorders, including angiogenesis, atherosclerosis, restenosis, and cancer.

专利号:US-6936477-B2
优先权日:1994-04-13
标题 :Complex combinatorial chemical libraries encoded with tags
发明人：STILL W CLARK; OHLMEYER MICHAEL H J; DILLARD LAWRENCE W; READER JOHN C; WIGLER MICHAEL H
权利人:COLD SPRING HARBOR LAB
摘要:Encoded combinatorial chemistry is provided, where sequential synthetic schemes are recorded using organic molecules, which define choice of reactant, and stage, as the same or different bit of information. Various products can be produced in the multi-stage synthesis, such as oligomers and synthetic non-repetitive organic molecules. Conveniently, nested families of compounds can be employed as identifiers, where number and/or position of a substituent define the choice. Alternatively, detectable functionalities may be employed, such as radioisotopes, fluorescers, halogens, and the like, where presence and ratios of two different groups can be used to define stage or choice. Particularly, pluralities of identifiers may be used to provide a binary or higher code, so as to define a plurality of choices with only a few detachable tags. The particles may be screened for a characteristic of interest, particularly binding affinity, where the products may be detachable from the particle or retained on the particle. The reaction history of the particles which are positive for the characteristic can be determined by the release of the tags and analysis to define the reaction history of the particle.