CAS: 36314-97-3; 2-Amino-4-Chloro-6-Phenylpyrimidine

相似化合物

133256-51-6 913322-47-1 392326-81-7

上下游产品

2-Amino-4,6-dichloropyrimidine phenylboronic acid 2-amino-6-phenyl-3H-pyrimidin-4-one 2-amino-4-hydroxy-6-phenylpyrimidine N4-diphenyl-pyrimidine-2,4-diyldiamine6,N4-diphenyl-pyrimidine-2,4-diyldiamine 4-methyl-6-phenylpyrimidine-2,4-diamineN4-methyl-6-phenylpyrimidine-2,4-diamine 2-amino-4-(2',4'-dichlorophenoxy)-6-phenylpyrimidine 2-amino-5-bromo-4-chloro-6-phenylpyrimidine

📜2-氨基-4-羟基-6-苯基嘧啶置于氯磺酸,三氯氧磷体系中,化学反应生成2-氨基-4-氯-6-苯基嘧啶
参考文献:作为潜在抗菌剂的新型磺酰脲类衍生物:化学合成,生物学评价和计算研究.
标题:作为潜在抗菌剂的新型磺酰脲类衍生物:化学合成,生物学评价和计算研究.
摘要:耐甲氧西林金黄色葡萄球菌 (Mrsa) 是一种全球性的健康威胁,在其悠久的历史中已经折磨着人类,因此迫切需要开发新型抗菌剂.本研究设计并合成了 21 种含有苯基-5-乙烯基和嘧啶基-4-芳基部分的新型磺酰脲类衍生物,其中 9 种化合物对革兰氏阳性菌具有抑制作用:Mrsa(朝阳临床分离株),金黄色葡萄球菌 Atcc6538,耐万古霉素肠球菌 309 (Vre-309) 和枯草芽孢杆菌 Atcc 6633.尤其是,9I 和 9Q 对四种细菌菌株表现出抑制活性,最低抑菌浓度 (Mic) 为 0.78-1.56 μg/ml,以及相当多的其他 Mrsa 临床菌株,Mic 为 0.78 μg/ml,优于阳性对照万古霉素(mic 为 1 μg/ml)和甲氧西林(mic >200 μg/ml).这是磺酰脲类衍生物首次被确定为针对不同 Mrsa 临床分离株的有希望的抑制剂.此外,所有合成化合物对白色念珠菌的
Doi:10.3390/antibiotics12020323

专利信息

专利号:WO-8604583-A1
优先权日:1985-02-05
标 题 :4-substituted-6-aryl pyrimidine compounds
发明人：SKULNICK HARVEY I; WIERENGA WENDELL
权利人:UPJOHN CO
摘要:Synthesis and anti-neoplastic use of 4-aziridyl-5-substituted/unsubstituted 6-aryl-pyrimidine compounds of formula (IA) as well as N'- AD2-(1-aziridyl)ethyl BD-6-aryl-2,4-pyrimidinediamines of formula (IB) and 4-chloro or bromo-5-substituted/unsubstituted -6-aryl-pyrimidines.

专利号:US-4795812-A
优先权日:1985-02-05
标题:4-substituted-6-aryl-pyrimidine compounds
发明人：WIERENGA WENDELL; SKULNICK HARVEY I
权利人:UPJOHN CO
摘要:PCT No. PCT/US86/00074 Sec. 371 Date Sep. 22, 1986 Sec. 102(e) Date Sep. 22, 1986 PCT Filed Jan. 23, 1986 PCT Pub. No. WO86/04583 PCT Pub. Date Aug. 14, 1986.This invention describes the synthesis and anti-neoplastic use of 4-aziridyl-5-substituted/unsubstituted 6-aryl-pyrimidine compounds of Formula IA IA as well as N'-[2-(1-aziridyl)ethyl]-6-aryl-2,4-pyrimidinediamines of Formula IB IB and 4-chloro or bromo-5-substituted/unstubstituted-6-aryl-pyrimidines.