专利号:US-6353112-B1 优先权日:1998-07-17 标 题:Sultams: Solid phase and other synthesis of anti-HIV compounds and compositions 发明人:BAKER DAVID C; JIANG BIN 权利人:UNIV TENNESSEE RES CORP 摘要:Biologically active sultams are disclosed which have potent anti-HIV activity. A combinational method of synthesis, which uses a solid support and variants thereof, are described. Biological compositions and method of treating mammals for viral infections with compositions comprising the sultams of the invention, especially HIV are described.
专利号:US-2024417358-A1 优先权日:2021-10-04 标题:Continuous Flow Reactor and Process for Synthesis of Substituted Benzoic Acid 发明人:JOSHI SUNIL SHANKAR; MALI NILESH ATMARAM 权利人:COUNCIL SCIENT IND RES 摘要:The present invention provides a non-hazardous, improved continuous oxidation process for the preparation of substituted benzoic acid of formula (I) by using continuous process reactor system with improved process controls. (I) wherein: R 1 is H, F, Cl, Br, I, NO 2 , amine, or C 1 -C 5 alkyl; R 2 is H, F, Cl, Br, I, NO 2 , amine, or C 1 -C 5 alkyl; and R 3 is H, F, Cl, Br, I, NO 2 , amine, C 1 -C 5 alkyl;
专利号:US-8735391-B2 优先权日:2008-09-26 标 题 :Synthesis of functionalized octahydro-isoquinolin-1-one-8-carboxamides, octahydro-isoquinolin-1-one-8-carboxylic esters and analogs, and therapeutic methods 发明人:AUBE JEFFREY; ROTH BRYAN L; GHOSH PARTHA; FRANKOWSKI KEVIN J 权利人:AUBE JEFFREY; ROTH BRYAN L; GHOSH PARTHA; FRANKOWSKI KEVIN J; UNIV KANSAS 摘要:A functionalized polycyclic compound can have a structure of Formula 1 or salt, prodrug, analog, or derivative thereof, which compound can be prepared by providing a diene; reacting the diene with a dienophile under sufficient conditions for a combined Diels-Alder/acylation reaction so as to provide a polycyclic compound having a carboxylic acid; and coupling the carboxylic acid with an amine-containing compound or a hydroxyl-containing compound so as to form an amide or an ester and producing a compound having a structure of Formula 1. The compound can be used for modulating an opioid receptor, which can be conducted by administering to an opioid receptor a functionalized polycyclic compound as described herein in an effective amount to modulate the functionality of the opioid receptor. Such opioid modulation can provide a biological benefit to a subject.
专利号:US-5710246-A 优先权日:1996-03-19 标题 :Process for intermediates for the synthesis of LHRH antagonists 发明人:FUNK KENNETH W; LUNDELL EDWIN O; MILLER ROBERT B; CHANG JANE L; KISHORE VIMAL; NAPIER JAMES J; STAEGER MICHAEL A 权利人:ABBOTT LAB 摘要:A method is provided for preparing decapeptide and undecapeptide derivatives of LHRH by solution phase peptide chemistry as well as intermediate peptides useful in the same method.
专利号:WO-9426779-A1 优先权日:1993-05-13 标 题 :PROCESSES AND INTERMEDIATE COMPOUNDS USEFUL FOR THE PREPARATION OF PLATELET GLYCOPROTEIN IIb/IIIa INHIBITORS 发明人:MADUSKUIE THOMAS PETER JR 权利人:DU PONT MERCK PHARMA 摘要:This invention provides processes and intermediates for the synthesis of platelet glycoprotein IIb/IIIa inhibitors of formula (I).
专利号:US-5186864-A 优先权日:1989-10-13 标题:Synthesis of dielectric liquids by improved friedel-crafts condensation 发明人:COMMANDEUR RAYMOND; BERGER NOELLE; JAY PIERRE; KERVENNAL JACQUES 权利人:ATOCHEM 摘要:Dielectric liquids are prepared by (a) Friedel-Crafts condensing at least one aromatic halide with at least one aromatic compound in the presence of a catalytically effective amount of ferric chloride, and thereafter deliberately avoiding any downstream destruction/neutralization and/or washing of such ferric chloride catalyst, (b) optionally, removing unreacted reactants from the medium of reaction, and (c) recovering from such medium of reaction a purified dielectric liquid; the subject process is thus environmentally improved by avoiding the generation of aqueous solutions containing contaminating amounts of objectionable organic compounds.