CAS: 2798-20-1; 5-Hydroxy-6,7,8-Trimethoxy-2-(4-Methoxyphenyl)-4H-Chromen-4-One
该化合物是一种自然形成的氟氯素化合物,被归类为聚甲基苯氧氟拉夫酮,主要存在于柑橘皮和某些药用植物中,它显示出显著的生物活动,包括抗氧化剂,抗炎和潜在的抗癌特性,可归因于它与多种甲氧基群体的独特分子结构.研究显示,园丁B可以调节细胞信号路径,如NF-XXB和MAPK, 有助于其治疗潜力.它的亲脂性增强了生物利用率,使它成为营养和药物应用的候选产品.通常使用HPLC和LC-MS等分析方法进行鉴定和量化.目前正在进行进一步的研究,以探讨其机械效应和临床相关性.
- 英文名称5-Hydroxy-6,7,8-Trimethoxy-2-(4-Methoxyphenyl)-4H-Chromen-4-One
- 中文名称栀子黄素
- IUPAC名称5-hydroxy-6,7,8-trimethoxy-2-(4-methoxyphenyl)-4H-chromen-4-one
- 其它别名5-Demethyltangeretin ; 5-Hydroxy-6,7,8-Trimethoxy-2-(4-Methoxyphenyl)-4H-1-Benzopyran-4-One
- CAS编号2798-20-1
- MFCD编号:MFCD03844829
- FDA UNII编号:313E89KN5E
- 分子式:C19H18O7分子量:358.35
- 产品CID: 1259894
- 产品分类天然产物 → 黄酮类化合物
物理性质
上下游产品
5,8-dihydroxy-6,7-dimethoxy-2-(4-methoxyphenyl)-4-benzopyrone dimethyl sulfate 2'-hydroxy-4,4',6'-trimethoxychalcone 1-(6-hydroxy-2,3,4-trimethoxyphenyl)-3-(4-methoxyphenyl)propenonetangeritin合成工艺路线路线简述
- 合成目标产物 Gardenin B 主要起始原料 Tangeretin
- (文献来源)合成步骤主要原料 Tangeretin
📜(E)-1-(2-羟基-4,6-二甲氧基苯基)-3-(4-甲氧基苯基)-2-丙烯-1-酮置于吡啶,碘,二甲基二环氧乙烷,三溴化硼,Potassium Carbonate体系中,用 二氯甲烷,丙酮 用作溶剂,化学反应 10.83H,反应生成栀子黄素
参考文献:Regioselective Hydroxylation Of 2-Hydroxychalcones By Dimethyldioxirane Towards Polymethoxylated Flavonoids
标题:Regioselective Hydroxylation Of 2-Hydroxychalcones By Dimethyldioxirane Towards Polymethoxylated Flavonoids
摘要:The Flavone Nucleus Is Part Of A Large Number Of Natural Products And Medicinal Compounds. In This Presentation The Novel Regioselective Hydroxylation Of Hydroxyarenes With Dmd Is Described. The Results Showed Further That Flavonoids With 5-Hydroxy Group Were Selectively Oxyfunctionalized At The Para-Position C8 Carbon Atom By Dmd. Finally,According To This Methodology,The Naturally occurring Isosinensetin,Tangeretin,Sinensetin,Nobiletin,Natsudaidain,Gardenin B,3,3',4',5,6,7,8-Heptamethoxyflavone,Quercetin And Its Derivatives Were Synthesized. (C) 2004 Elsevier Ltd. All Rights Reserved.
Doi:10.1016/j.Tet.2004.01.023
海关参考信息
- 2905110000-甲醇
2907210001-间苯二酚
2907221000-对苯二酚
2908199090-其他酚的卤化衍生物 - 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
- 详情请参考：📖 海关编码查询和海关进出口税则
供应商参考报价(招募中)
品牌试剂参考报价(招募中)
📌 第三方产品分析报告
主要参考文献
参考标题:Semisynthesis Of Polymethoxyflavonoids From Naringin And Hesperidin作者:Yue Li,Shuanglian Cai,Kailin He,Qiuan Wang |发布日期:2014.5
摘要:Glycoside Hydrolysis, Dehydrogenation, Bromination, Aromatic Nucleophilic Substitution, O-Methylation, Dimethyldioxirane Oxidation And Regioselective Demethylation, Starting From Abundant And Inexpensive Natural Sources Naringin And Hesperidin. A New Synthetic Method For Selective Methylation Using Cubr Catalysed And Microwave-Assisted Reaction Was Developed, And The Dimethyl Dioxirane Oxidation Of
合成参考文献
参考文献:10.1016/j.ijbiomac.2020.07.305
摘要:Huang X, Zhu J, Wang L, Jing H, Ma C, Kou X, Wang H. Inhibitory mechanisms and interaction of tangeretin, 5-demethyltangeretin, nobiletin, and 5-demethylnobiletin from citrus peels on pancreatic lipase: Kinetics, spectroscopies, and molecular dynamics simulation. International Journal of Biological Macromolecules. 2020 Dec;164():1927–38. doi: 10.1016/j.ijbiomac.2020.07.305.
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