CAS: 2349-58-8; 4,5-Diphenyl-1H-Imidazole-2-Thiol

该化合物是一种有机化合物,其特征是其imidazole环结构,即五人组成的含有两个氮原子的环环化合物,该物质具有附属于imidazole环的4和5个位置的两个苯基组,有助于其独特的化学特性.该物质是一种硫醇,意即含有一个硫基(-SH)组,具有硫化物的再活动特征,例如形成脱硫联结和参加再毒反应的能力.该苯基组的存在增强了其缺水性,并可能影响其在有机溶剂中的溶性.4,5-二苯基-imidazolethiol经常被研究其在医药化学领域的潜在应用,特别是在制药领域和作为离子化学协调体.其特性还可能与生物化学和材料科学领域相关,例如形成脱硫联体和参加再毒反应的能力.

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668-94-0 15061-34-4 73181-95-0

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合成工艺路线路线简述

    📜Diphenyl-4,5-Thioxo-2-Imidazoline置于sulfur体系中,化学反应 1.0H,以75%的收率获得4,5-二苯基-2-咪唑硫醇
    参考文献:Hammouda,Hamdy Ali; Abd-Allah,Sanaa Osman; Zoorob,Hanafi Hassan,Acta Chimica Hungarica,1985,Vol. 119,# 1,P. 49-56
    标题:Hammouda,Hamdy Ali; Abd-Allah,Sanaa Osman; Zoorob,Hanafi Hassan,Acta Chimica Hungarica,1985,Vol. 119,# 1,P. 49-56

    海关参考信息

    专利信息


    专利号:US-5948789-A
    优先权日:1994-07-15
    标题:Process for synthesis of substituted sulphoxides
    发明人：LARSSON MAGNUS ERIK; STENHEDE URBAN JAN; SOERENSEN HENRIK; VON UNGE SVERKER PER OSKAR; COTTON HANNA KRISTINA
    权利人:ASTRA AB
    摘要:PCT No. PCT/SE95/00818 Sec. 371 Date Jul. 14, 1995 Sec. 102(e) Date Jul. 14, 1995 PCT Filed Jul. 3, 1995 PCT Pub. No. WO96/02535 PCT Pub. Date Feb. 1, 1996A novel process for enantioselective synthesis of single enantiomers of omeprazole or its alkaline salts, of other optically pure substituted 2-(2-pyridinylmethyl-sulphinyl) -1H-benzimidazoles as well as of other structurally related sulphoxides or their alkaline salts. The claimed process is an asymmetric oxidation of a pro-chiral sulphide to the single enantiomers or an enantiomerically enriched form of the corresponding sulphoxide. The application also claims the enantiomeric sulphoxide products produced by the process and their use in medicine.

    专利号:US-H1729-H
    优先权日:1996-05-09
    标 题 :Method for preparing compounds employing solid phase synthesis and novel linker-resin
    发明人：BILLER SCOTT A; LAWRENCE R MICHAEL; POSS MICHAEL A
    权利人:BRISTOL MYERS SQUIBB CO
    摘要:A method is provided for preparing various intermediates and final products including MTP inhibitors employing solid phase syntheses. A new dialkoxyaryl aldehyde linker-resin of the structure ##STR1## which serves as a starting material and method for preparing same, are also provided.

    专利号:UA-47409-C2
    优先权日:1994-07-15
    标 题 :Translated By Plaj METHOD FOR SYNTHESIS OF SUBSTITUTED SULFOXIDES (VERSIONS) AND SULFOXIDE

    专利号:EP-0773940-B2
    优先权日:1994-07-15
    标 题:Process for synthesis of substituted sulphoxides

    专利号:WO-9602535-A1
    优先权日:1994-07-15
    标 题:Process for synthesis of substituted sulphoxides

    专利号:JP-3795917-B2
    优先权日:1994-07-15
    标 题:Synthesis of substituted sulfoxides

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    合成参考文献


    摘要:Eichman, C. C.; Stambuli, J. P., Science of Synthesis: Cross Coupling and Heck-Type Reactions, (2012) 2, 391.
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