专利号:US-2023286918-A1 优先权日:2020-07-02 标 题:Manufacturing process for 3,5-dichloropicolinonitrile for synthesis of vadadustat 发明人:JURKAUSKAS VALDAS; JUNG YOUNG CHUN; KWON TAESOO; KANNAN ARUNACHALAM; GONDI VIJAYA BHASKER 权利人:AKEBIA THERAPEUTICS INC 摘要:Disclosed herein are methods and processes of preparing vadadustat or a pharmaceutically acceptable salts thereof, and intermediates (e.g., a compound of Formula (I), (I-F), (II), or (IV), or a pharmaceutically acceptable salts thereof) useful for the synthesis of vadadustat.
专利号:WO-2025059840-A1 优先权日:2023-09-19 标题 :Nano-cobalt(ii) hydroxide, preparation method therefor, and use thereof 发明人:LU XINGHUA; RUAN DINGSHAN; LI CHANGDONG; LIU GENGHAO; ZHOU SIYUAN; ZHANG PENG 权利人:GUANGDONG BRUNP RECYCLING TECHNOLOGY CO LTD; HUNAN BRUNP RECYCLING TECH CO LTD 摘要:A nano-cobalt(II) hydroxide, a preparation method therefor, and a use thereof, belonging to the technical field of lithium-ion batteries. The preparation method comprises: reacting a cobalt salt solution and a precipitant solution at 30-35 ℃, and during the reaction process, adjusting the amount of precipitant solution added so as to control the pH of the reaction system to be 13-13.5, and after the reaction is finished, obtaining a nano-cobalt(II) hydroxide slurry. The precipitant solution comprises a liquid alkali and a deflocculant, and the mass ratio of the solute in the liquid alkali to the deflocculant is 1:0.02-0.05. Carrying out the reaction at a lower temperature prevents particle agglomeration caused by intensified Brownian motion among particles, thus facilitating the synthesis of ultra-fine nano-cobalt(II) hydroxide while reducing energy consumption; when the interaction forces between molecules become stronger, the use of both a higher pH and the deflocculant allows good dispersibility to still be maintained, thus reducing the occurrence of agglomeration; and the obtained crystal grains are small in size, are not prone to agglomerate, and have good dispersibility.
专利号:US-12269802-B2 优先权日:2018-05-09 标题:Process for preparing 2-[[5-(3-chlorophenyl)-3-hydroxypyridine-2-carbonyl] amino] acetic acid 发明人:GORIN BORIS I; LANTHIER CHRISTOPHER M; LUONG ANNE BUU CHAU; COPP JAMES DENSMORE; GONZALEZ JAVIER; JAUTZE SASCHA; KRAUS ERICH; O'CONNOR ALAN 权利人:AKEBIA THERAPEUTICS INC 摘要:Disclosed herein are methods and processes of preparing vadadustat and pharmaceutically acceptable salts thereof, and intermediates of formula (I) and their salts useful for the synthesis of vadadustat.
专利号:WO-2023093142-A1 优先权日:2021-11-23 标题 :Preparation method for high-voltage lithium cobalt oxide positive electrode material 发明人:XU KAIHUA; ZHANG AIQING; CAO GUOLIN; JIN ZHUOMIN; LI BINGZHONG; YANG KETAO; SHI QIYONG; XIE JINDE; MA XINGXING 权利人:GEM JIANGSU COBALT IND CO LTD 摘要:The present invention relates to the technical field of preparation of high-voltage lithium cobalt oxide positive electrode materials, and provides a preparation method for a high-voltage lithium cobalt oxide positive electrode material. The method comprises: mixing a cobalt containing solution with a metal M-doped compound, controlling the pH value in an intermittent reactor, performing wet synthesis into small and large particle size doped cobaltous hydroxides, oxidizing the small and large particle size doped cobaltous hydroxides by means of a hydrogen peroxide solution to obtain small and large particle size doped hydroxyl cobalt oxides; washing, drying, and calcining the small and large particle size doped hydroxyl cobalt oxides to obtain small and large particle size doped tricobalt tetraoxides; mixing the small and large particle size doped tricobalt tetraoxides with battery-grade lithium carbonate, respectively, sintering, cooling, crushing and sieving the mixture to obtain small and large particle size doped lithium cobalt oxides; and mixing the large and small particle size doped lithium cobalt oxides according to a set mass ratio to obtain the high-voltage lithium cobalt oxide positive electrode material. According to the present invention, solid-phase doping of lithium cobalt oxide can be uniform, the compaction density, the processing performance and the structural stability of the high-voltage lithium cobalt oxide positive electrode material are improved, and the cycle performance and the rate capability of the battery are improved.
参考文献:10.1007/s00232-003-0614-2 摘要:Castelli L, Tanzi F, Taglietti V, Magistretti J. Cu 2+ , Co 2+ , and Mn 2+ Modify the Gating Kinetics of High-Voltage-Activated Ca 2+ Channels in Rat Palaeocortical Neurons. Journal of Membrane Biology. 2003 Oct 01;195(3):121–36. doi: 10.1007/s00232-003-0614-2.