CAS: 1871-57-4; 3-Chloro-2-Chloromethyl-1-Propene

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3-氯-2,2-二氯甲基丙酸 以99%的收率获得3-氯-2-氯甲基丙烯
参考文献:3-Chloro-2-(Chloromethyl)-1-Propene
标题:3-Chloro-2-(Chloromethyl)-1-Propene
摘要:
Doi:10.15227/orgsyn.075.0089

专利信息

专利号:US-5231232-A
优先权日:1991-12-18
标题 :Method of preparing C-18 ketones used in the manufacture of Vitamins E and K
发明人：BABLER JAMES H
权利人:UNIV LOYOLA CHICAGO
摘要:Methods of forming unsaturated C-18 ketones which can be used in the synthesis of Vitamins E and K 1 are disclosed. One procedure involves coupling a C-9 primary allylic halide to a carbonyl-group-containing C-9 terminal alkyne. A second, two-step procedure employs a C-4 bis allylic halide (molar excess) and a carbonyl-group-containing C-9 terminal alkyne to form a C-13 primary allylic halide. The C-13 primary allylic halide can then be converted to the desired C-18 ketone by reaction with 2-methyl-3-butyn-2-ol. Novel C-18 ketones (e.g., 14-hydroxy-6,14-dimethyl-10-methylene-5-pentadecen-7,12-diyn-2-one), C-13 allylic halides (e.g., 10-chloromethyl-6-methyl-5,10-undecadien-7-yn-2-one) and C-9 allylic halides (e.g., 6-chloromethyl-2-methyl-6-hepten-3-yn-2-ol) are formed in the process.

专利号:US-9193682-B2
优先权日:2013-04-05
标题:Synthesis of trithiocarbonates and allyl sulfides and their application into advances in covalent adaptable networks
发明人：FENOLI CHRISTOPHER R; BOWMAN CHRISTOPHER N
权利人:FENOLI CHRISTOPHER R; BOWMAN CHRISTOPHER N
摘要:Monomers having a C-B-A-B-C structure are disclosed, where A is a core of either trithiocarbonate and allyl sulfide, where B are linker units, and where C are end units. The end units may comprise acrylates, methacrylates, alcohol(s), amine(s), and alkynes, among others. The linker units may include an alkane, alkene, phenyl, diphenyl, or benzylic group, among others. Methods of synthesizing such compounds are also disclosed.

专利号:US-2009111737-A1
优先权日:1999-05-24
标题:Novel antibacterial agents
发明人：CHRISTENSEN BURTON G; MORAN EDMUND J; GRIFFIN JOHN H; JUDICE J KEVIN; MU YONGQI; PACE JOHN L; MAMMEN MATHAI; AGGEN JAMES
权利人:CHRISTENSEN BURTON G; MORAN EDMUND J; GRIFFIN JOHN H; JUDICE J KEVIN; MU YONGQI; PACE JOHN L; MAMMEN MATHAI; AGGEN JAMES
摘要:This invention relates to novel multibinding compounds (agents) that are antibacterial agents. The multibinding compounds of the invention comprise from 2-10 ligands covalently connected by a linker or linkers, wherein each of said ligands in their monovalent (i.e., unlinked) state have the ability to bind to a an enzyme involved in cell wall biosynthesis and metabolism, a precursor used in the synthesis of the bacterial cell wall and/or the bacterial cell surface thereby interfere with the synthesis and/or metabolism of the cell wall. In particular the multibinding compounds of the invention comprise from 2-10 ligands covalently connected by a linker or linkers, wherein each of said ligands hasn a ligand domain capable of binding to penicillin binding proteins, a transpeptidase enzyme, a substrate of a transpeptidase enzyme, a beta-lactamase enzyme, pencillinase enzyme, cephalosporinase enzyme, a transglycoslase enzyme, or a transglycosylase enzyme substrate; Preferably, the ligands are selected from the beta lactam or glycopeptide class of antibacterial agents.

专利号:US-9458100-B2
优先权日:2012-10-12
标 题:Synthesis and growth regulatory activity of a prototype member of a new family of aminothiol radioprotectors
发明人：FAHL WILLIAM E
权利人:WISCONSIN ALUMNI RES FOUND
摘要:The synthesis, growth inhibition and radioprotective activity of the PrC-210 aminothiol, 3-(methyl-amino)-2-((methylamino)methyl)propane-1-thiol, and its polyamine and thiolated polyamine progenitors are reported. All of the molecules significantly inhibited growth of cultured normal human fibroblasts. The combination of an ROS-scavenging thiol group and a positively charged alkyl-amine backbone provided the most radioprotective aminothiol molecule.

专利号:US-11000625-B2
优先权日:2017-06-15
标 题:Amplified photodegradation of hydrogels and methods of producing the same
发明人：ANSETH KRISTI; MAROZAS IAN; BROWN TOBIN
权利人:UNIV COLORADO REGENTS
摘要:This invention is in the field of synthesis and amplified photodegradation of hydrogel network and methods of producing and using the same.

专利号:US-2014303391-A1
优先权日:2013-04-05
标题:Synthesis of trithiocarbonates and allyl sulfides and their application into advances in covalent adaptable networks