CAS: 18600-42-5; (4-Nitrophenyl)Methanamine Hydrochloride

上下游产品

N,N′-bis(4-nitrobenzyl)urea 4-nitrobenzyl chloride 4-nitrobenzamide 4-nitrobenzonitrile 1-(4-nitrobenzyl)-1H-pyrrole 1-(4-Nitrobenzyl)-2-Mercapto-5-Hydroxymethylimidazole N-(4-Methoxyphenyl)-3-(4-nitrobenzylamino)-2-phenylcrotonthioamid 4-chloro-N-[morpholino(thi°Carbonyl)]-N'-(4-nitrobenzyl)benzamidine

对硝基苯甲腈置于三乙烯二胺,盐酸,Tris(2,6-Difluorophenyl)Borane体系中,用 1,4-二氧六环,乙醚,氘代氯仿 用作溶剂,化学反应 18.0H,反应生成4-硝基苄胺盐酸盐
参考文献:受挫的路易斯对催化丁腈的硼氢化:Flp 与硼催化
标题:受挫的路易斯对催化丁腈的硼氢化:Flp 与硼催化
摘要:开发了一种受挫的路易斯对催化的芳族和脂族腈的硼氢化.该催化剂以 77-99% 的高产率提供伯胺,催化剂负载量低至 2 Mol%.该反应对酯,酰胺,硝基和脂肪族卤化物表现出高官能团耐受性.将二硼化胺添加到 3-苯基丙酸乙酯中以 Z 选择性进行,Dr 大于 99:1,两步产率为 77-90%.通过控制和计算实验研究了反应机理.
Doi:10.1002/adsc.202200525

专利信息

专利号:US-5254558-A
优先权日:1991-08-15
标 题:Substituted 1,3-diazines as leukocyte elastase inhibitors
发明人：BERNSTEIN PETER R; EDWARDS PHILIP D; THOMAS ROYSTON M; VEALE CHRIS A; WARNER PETER; WOLANIN DONALD J
权利人:ICI PLC
摘要:The present invention relates to certain novel substituted heterocycles which are 1-pyrimidinylacetamide compounds of formula I, set out herein, which are inhibitors of human leukocyte elastase (HLE), also known as human neutrophil elastase (HNE), making them useful whenever such inhibition is desired, such as for research tools in pharmacological, diagnostic and related studies and in the treatment of diseases in mammals in which HLE is implicated. The invention also includes intermediates useful in the synthesis of these substituted heterocycles, processes for preparing the substituted heterocycles, pharmaceutical compositions containing such substituted heterocycles and methods for their use.

专利号:WO-2009055519-A1
优先权日:2007-10-26
标题 :Synthesis of quaternary salt compounds

专利号:US-2009112003-A1
优先权日:2007-10-26
标 题 :Synthesis of quaternary salt compounds

专利号:US-8093428-B2
优先权日:2007-10-26
标 题 :Synthesis of quaternary salt compounds
发明人：LI XUN
权利人:LI XUN; JANSSEN PHARMACEUTICA NV
摘要:The present invention is directed to a process, having a reduced environmental impact, for preparing phenylamino substituted quaternary salt compounds that are CCR2 antagonists.

专利号:CN-107417623-B
优先权日:2017-04-19
标 题:A method for one-step synthesis of 5-diarylaminobenzimidazole derivatives

专利号:EP-2212286-A1
优先权日:2007-10-26
标题 :Synthesis of quaternary salt compounds