CAS: 180516-87-4; 4-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-yl)Benzoic Acid

上下游产品

2,3-dimethyl-2,3-butane diol 4-carboxyphenylboronic acid 4-formylphenylboronic acid, 4-iodobenzoic acid 3′,4′-dichloro-[1,1′-biphenyl]-4-carboxylic acid 4-(2-methoxyphenyl)benzoic acid 3'‐methyl‐(1,1'‐biphenyl)‐4‐carboxylic acid 4′‐cyano‐[1,1′‐biphenyl]‐4‐carboxylic acid

4-甲酰基苯硼酸频哪醇酯置于氧气体系中,用 乙腈 用作溶剂,80.0 °C,101.33 Kpa 条件下,反应 24.0H,以36 Mg的收率获得4-羧基苯硼酸频那醇酯
参考文献:相互排斥的催化反应的顺序连接,通过控制mof催化剂的存在的方法:醇一锅氧化成羧酸
标题:相互排斥的催化反应的顺序连接,通过控制mof催化剂的存在的方法:醇一锅氧化成羧酸
摘要:一种功能化的金属-有机骨架(mof)催化剂,用于将醇依次单锅氧化为羧酸,可控制非均相催化剂的存在.使用众所周知的氨基-氧自由基官能化的mof通过需氧氧化将醇转化为醛.在同一烧瓶中,通过温和加热溶液对自由基mof进行简单过滤,完全改变了反应介质,从而提供了无自由基清除剂的条件,适合于第一步中形成的醛自氧化为羧酸.相互排斥的自由基催化的好氧氧化(带有mof的第一步)和自由基抑制的自氧化(不带有mof的第二步)依次实现.总体,我们展示了一种通过使用易于官能化的异质mof将醇类依次氧化为羧酸的有效方法.此外,我们的mof进出方法可以以环境友好的方式用于将醇氧化为具有广泛的官能团耐受性的工业和经济价值的羧酸,包括2,5-呋喃二甲酸和1,4-苯二甲酸,具有非常好的收率和可重复使用性.此外,Mof-Tempo作为一种抗氧化稳定剂,可防止醛类发生不希望的氧化,而这种反应性mof的完美"可回收性"需要从催化和
Doi:10.1021/acs.Inorgchem.0C02809

专利信息

专利号:US-2023286915-A1
优先权日:2020-10-07
标 题 :Synthesis of pyrrole acid derivatives
发明人：WILKINSON ANDREW; COOPER LAN; ORR DAVID; FINLAYSON JONATHAN; BUNT ADAM; KIRKHAM JAMES; LYTH DAVID; BLADES KEVIN
权利人:INFEX THERAPEUTICS LTD
摘要:This invention relates to the synthesis of compounds that can be used to treat bacterial infections in combination with other antibacterial agents, and more specifically in combination with a class of antibacterial agents known as carbapenems. The compounds resulting from the novel methods of the present invention are enzyme inhibitors and more particularly are metallo-β-lactamase inhibitors.

专利号:US-7465842-B2
优先权日:2004-08-26
标 题 :Enantioselective biotransformation for preparation of protein tyrosine kinase inhibitor intermediates
发明人：KUNG PEI-PEI; MARTINEZ CARLOS; TAO JUNHUA
权利人:AGOURON PHARMA
摘要:The invention relates to biocatalytic methods for preparing enantiomerically pure stereoisomers of 1-(2,6-dichloro-3-fluorophenyl)ethanol. Disclosed are methods of preparation of the desired (S)-enantiomer, which methods are based on a combination of enzymatic resolution, chemical esterification and chemical hydrolysis with inversion of 1-(2,6-dichloro-3-fluorophenyl)ethyl esters or stereoselective bio-reduction of 2,6-dichloro-3-fluoro-acetophenone with a biocatalyst such as an enzyme or a microorganism. The chiral (S)-enantiomer can be used in the synthesis of certain enantiomerically enriched, ether linked 2-aminopyridine compounds that potently inhibit auto-phosphorylation of human heptocyte growth factor receptor.

专利号:US-10995078-B2
优先权日:2013-03-13
标 题:Compounds and compositions for inhibition of FASN
发明人：BAIR KENNETH W; LANCIA JR DAVID R; LI HONGBIN; LOCH JAMES; LU WEI; MARTIN MATTHEW W; MILLAN DAVID S; SCHILLER SHAWN E R; TEBBE MARK J
权利人:FORMA THERAPEUTICS INC
摘要:The present invention relates to compounds and composition for inhibition of FASN, their synthesis, applications, and antidotes. An illustrative compound of the invention is shown below:

专利号:CN-116209652-A
优先权日:2020-10-07
标题:Synthesis of pyrrole acid derivatives

专利号:US-7122694-B2
优先权日:1998-11-06
标 题 :Hydroboronation process
发明人：MARCUCCIO SEBASTIAN MARIO; RODOPOULOS MARY; WEIGOLD HELMUT
权利人:BORON MOLECULAR PTY LTD
摘要:The invention relates to processes for the synthesis of aryl or alkene borates which comprises reacting: (i) an olefinic compound having a halogen or halogen-like substituent in a vinylic substitution position, or (ii) an aromatic ring having a halogen or halogen-like substituent in a ring substitution position, with a disubstituted monohydroborane in the presence of a Group 8-11 metal catalyst. The invention also relates to the use of these borates in coupling reactions. The invention further relates to certain disubstituted monohydroboranes and aryl or alkene borates.

专利号:WO-2022074385-A1
优先权日:2020-10-07
标 题:Synthesis of pyrrole acid derivatives