CAS: 1776-53-0; 4-Aminocyclohexanecarboxylic Acid

相似化合物

3685-25-4 3685-23-2 27960-59-4

上下游产品

CAS号150-13-0 对氨基苯甲酸 | CAS号7732-18-5 水 | CAS号71-41-0 正戊醇 | CAS号51498-33-0 4-氨基环己烷-1-甲酸乙酯 | CAS号280-38-6 2-氮杂双环(2.2.2)辛烷 | CAS号53292-90-3 顺-4-(叔丁氧羰氨基)环己甲酸 | CAS号61367-07-5 4-氨基环己甲酸甲酯盐酸盐 | CAS号1467-84-1 (反式-4-氨基环己基)甲醇 | CAS号3306-69-2 2-氮杂双环[2.2.2]辛烷-3-酮 | CAS号175867-59-1 4-氨基环己烷羧酸甲酯 | CAS号1678-68-8 反式-4-氨基环己烷羧酸乙酯 | CAS号147900-46-7 反-4-Fm°C-氨基环己烷甲酸 | CAS号5845-15-8 2-氮杂双环[2.2.2]辛烷盐酸盐

Trans-Tert-Butyl 4-Tert-Butylsulfinamidocyclohexanecarboxylate置于甲醇,水,三氟乙酸,Lithium Hydroxide体系中,用 二氯甲烷 用作溶剂,化学反应 1.0H,反应生成4-氨基环己烷羧酸
参考文献:一种反式4-(叔丁氧羰氨基)环己烷羧酸及其中间体的制备方法
标题:一种反式4-(叔丁氧羰氨基)环己烷羧酸及其中间体的制备方法
摘要:本发明提供了一种反式4‑(叔丁氧羰氨基)环己烷羧酸及其中间体的制备方法,其特征在于包括如下制备步骤:以4‑氧代环己烷羧酸酯和手性配体试剂叔丁基亚磺酰胺为原料,在路易斯酸催化下还原胺化得到反式‑4‑叔丁基亚磺酰胺环己烷羧酸酯,本发明采用手性配体试剂叔丁基亚磺酰胺与4‑氧代环己烷羧酸酯缩合得到的中间体,使其还原反应具有高度立体选择性,反式产物的比例大于95%,同时叔丁基亚磺酰基团在碱性条件下稳定而在酸性条件下易离去,反应条件温和,操作简便,收率高,易于工业化生产.

专利信息

专利号:US-9206222-B2
优先权日:2009-06-29
标题:Solid phase peptide synthesis of peptide alcohols
发明人：CAUSSIL-AMBLARD MURIEL; MARTINEZ JEAN; TAILHADES JULIEN
权利人:CAUSSIL-AMBLARD MURIEL; MARTINEZ JEAN; TAILHADES JULIEN; CENTRE NAT RECH SCIENT
摘要:The present invention relates to the synthesis of depsipeptides on solid phase support. Said depsipeptides are then implicated in a solution phase O—N acyl shift enabling to obtain the corresponding peptide alcohols.

专利号:US-2023364251-A1
优先权日:2020-08-06
标 题:Methods for the synthesis of protein-drug conjugates
发明人：BORCHARDT ALLEN; HUGHES ROBERT MICHAEL
权利人:CIDARA THERAPEUTICS INC
摘要:The present invention relates to intermediates and methods for synthesizing protein-drug conjugates that can be used for the treatment of diseases and related conditions.

专利号:US-8546533-B2
优先权日:2008-08-29
标 题:Pipecolic linker and its use for chemistry on solid support
发明人：MARTINEZ JEAN; ZAJDEL PAWEL; PAWLOWSKI MACIEJ; SUBRA GILLES
权利人:MARTINEZ JEAN; ZAJDEL PAWEL; PAWLOWSKI MACIEJ; SUBRA GILLES; CENTRE NAT RECH SCIENT; UNIV MONTPELLIER 1; UNIV JAGELLONE; UNIV MONTPELLIER II
摘要:The present invention relates to a pipecolic linker and its use as a solid-phase linker in organic synthesis. Said pipecolic solid-phase linker may be used for coupling functional groups chosen between primary amines, secondary amines, aromatic amines, alcohols, phenols and thiols. In particular, said pipecolic solid-phase linker may be used for peptide or pseudopeptide synthesis, such as the reverse N to C peptide synthesis or the retro-inverso peptide synthesis, or for the synthesis of small organic molecules.

专利号:WO-02083606-A1
优先权日:2001-04-17
标 题:A linker system for the synthesis and screening of combinatorial libraries of polyamine derivatives on water compatible supports
发明人：HALL DENNIS G; WANG FAN
权利人:UNIV ALBERTA; HALL DENNIS G; WANG FAN
摘要:The invention is directed to resin-conjugated polyamine combinatorial libraries and methods for making and using them, e.g., methods for screening for polyamine binding molecules in biological samples. The invention provides protected benzophenone-substituted resins, and methods for their synthesis. The invention provides hydroxy-triarylmethane-conjugated resins, and methods for their synthesis. The invention provides chlorotriarylmethane resins, and methods for their synthesis. The invention provides resin-conjugated peptide libraries, and methods for their synthesis.

专利号:US-6933303-B2
优先权日:2001-10-19
标 题:Heteroaryl-fused nitrogen heterocycles as therapeutic agents
发明人：MJALLI ADNAN M M; ANDREWS ROBERT C; XIE RONGYUAN; YARRAGUNTA RAVINDRA R; REN TAN
权利人:TRANSTECH PHARMA INC
摘要:This invention provides compounds which are useful as inhibitors of protein tyrosine phosphatases (PTPases). As inhibitors of PTPases, the compounds of the invention are useful for the management, treatment, control and adjunct treatment of diseases mediated by PTPase activity. Such diseases include type I diabetes, type II diabetes, immune dysfunction, AIDS, autoimmunity, glucose intolerance, obesity, cancer, psoriasis, allergic diseases, infectious diseases, inflammatory diseases, diseases involving the modulated synthesis of growth hormone or the modulated synthesis of growth factors or cytokines which affect the production of growth hormone, or Alzheimer's disease.

专利号:US-9951181-B2
优先权日:2013-10-21
标题:Polyamides containing the bio-based 2,5-furandicarboxylic acid
发明人：SMITH DEEDEE; FLORES JOEL; ABERSON RENÉ; DAM MATHEUS ADRIANUS; DUURSMA ATE; GRUTER GERARDUS JOHANNES M
权利人:FURANIX TECHNOLOGIES BV; SYNVINA C V
摘要:Polyamides are made from the polycondensation of monomers including from 15 to 80 mol % of 2,5-furandicarboxylic acid (FDCA), from 20 to 85 mol % of at least one aromatic dicarboxylic acid and from 50 to 100 mol % of at least one aliphatic diamine selected from those including 6 and 7 carbon atoms. A process allowing the synthesis of high molecular weight polyamides made from the above mentioned monomers is also described. Finally, compositions and articles including the same polyamides are also disclosed.