CAS: 164858-78-0; (R)-2-(2-(Diphenylphosphino)Phenyl)-4-Isopropyl-4,5-Dihydrooxazole

上下游产品

potassium diphenylphosphine (R)-2-amino-3-methylbutanol

D-缬氨醇 反应生成(R)-(+)-2-[2-(二苯基膦)苯基]-4-异丙基二恶唑
参考文献:In Situ Enzymatic Screening (Ises) Of P,N-Ligands For Ni(0)-Mediated Asymmetric Intramolecular Allylic Amination
标题:In Situ Enzymatic Screening (Ises) Of P,N-Ligands For Ni(0)-Mediated Asymmetric Intramolecular Allylic Amination
摘要:An In Situ Enzymatic Screening (Ises) Approach To Rapid Catalyst Evaluation Recently Pointed To Ni(0) As A New Candidate Transition Metal For Intramolecular Allylic Amination. This Led To Further Exploration Of Chiral Bidentate Phosphine Ligands For Such Transformations. Herein,A Variety Of P,N-Ligands Are Examined For This Ni(0)-Chemistry,Using A Model Reaction Leading Into The Vinylglycinol Scaffold. On The One Hand,An N,N-Bis(2-Diphenylphosphinoethyl)Alkylamine ('Pnp') Ligand Proved To Be The Fastest Ligand Yet Seen For This Ni(0)-Transformation. On The Other,Phosphinooxazoline (Phox) Ligands Of The Pfaltz-Helmchen-Williams Variety Gave The Highest Enantioselectivities (Up To 51% Ee) Among P,N-Ligands Examined. (C) 2004 Elsevier Ltd. All Rights Reserved.
Doi:10.1016/j.Tetasy.2004.06.052

专利信息

专利号:US-9518034-B2
优先权日:2013-10-14
标题 :Synthesis of chiral enaminones, their derivatives, and bioactivity studies thereof
发明人：STOLTZ BRIAN M; DOUGHERTY DENNIS A; DUQUETTE DOUGLAS; DUFFY NOAH
权利人:CALIFORNIA INST OF TECHN
摘要:This invention provides enantioenriched heterocyclic enaminone compounds with quaternary stereogenic centers and novel methods of preparing the compounds. Methods include the method for the preparation of a compound of formula (I): n ncomprising treating a compound of formula (II):n n nwith a transition metal catalyst under alkylation conditions.

专利号:US-11377396-B2
优先权日:2014-12-18
标题 :Enantioselective synthesis of α-quaternary Mannich adducts by palladium-catalyzed allylic alkylation
发明人：STOLTZ BRIAN M; NUMAJIRI YOSHITAKA; PRITCHETT BEAU P; CHIYODA KOJI
权利人:CALIFORNIA INST OF TECHN
摘要:This invention provides enantioenriched Mannich adducts with quaternary stereogenic centers and novel methods of preparing the compounds. Methods include the method for the preparation of a compound of formula (I): n ncomprising treating a compound of formula (II):n n nwith a transition metal catalyst under alkylation conditions.

专利号:US-2016096810-A1
优先权日:2014-10-07
标 题 :Enantioselective synthesis of dialkylated n,o-heterocycles by palladium-catalyzed allylic alkylation
发明人：STOLTZ BRIAN M; NUMAJIRI YOSHITAKA; BEHENNA DOUGLAS C
权利人:STOLTZ BRIAN M; NUMAJIRI YOSHITAKA; BEHENNA DOUGLAS C
摘要:This invention provides enantioenriched N,O-heterocyclic compounds with quaternary stereogenic centers and novel methods of preparing the compounds. Methods include the method for the preparation of a compound of formula (I): n n n n n n n n n n comprising treating a compound of formula (II): n n n n n n n n n n with a transition metal catalyst under alkylation conditions.

专利号:US-2020157020-A1
优先权日:2014-12-18
标题:Enantioselective synthesis of alpha-quaternary mannich adducts by palladium-catalyzed allylic alkylation

专利号:US-2015105552-A1
优先权日:2013-10-14
标 题 :Synthesis of chiral enaminones, their derivatives, and bioactivity studies thereof

专利号:US-2016176773-A1
优先权日:2014-12-18
标 题 :ENANTIOSELECTIVE SYNTHESIS OF alpha-QUATERNARY MANNICH ADDUCTS BY PALLADIUM-CATALYZED ALLYLIC ALKYLATION