专利号:US-2009143426-A1 优先权日:2007-12-04 标 题:Synthesis of 1,3,6-trisubstituted-2-carboxyquinol-4-ones as selective ET A antagonists and their use as medicaments 发明人:STEPHANI RALPH ANTHONY; PATEL HARDIK JITENDRA; REZNIK SANDRA EVE; CANTOR JEROME OWEN 权利人:STEPHANI RALPH ANTHONY; PATEL HARDIK JITENDRA; REZNIK SANDRA EVE; CANTOR JEROME OWEN 摘要:The invention discloses the composition and preparation of various 1,3,6-trisubstituted-2-carboxy-quinol-4-ones of the formula 1 where R is H, alkyl, haloalkyl or hydroxyalkyl, R′ is alkyl, nitro, halogen or NR 2 ′″ where R′″ is alkyl or cycloalkyl, and R″ is H or alkyl. The composition of the invented compounds as methods of antagonizing the action of endothelin-1 to treat cardiovascular, pulmonary diseases and obstetric disorders and preterm labor and preeclampsia in mammals is disclosed.
专利号:US-11225655-B2 优先权日:2010-04-16 标题:Bi-functional complexes and methods for making and using such complexes 发明人:GOULIAEV ALEX HAAHR; FRANCH THOMAS; GODSKESEN MICHAEL ANDERS; JENSEN KIM BIRKEBAEK 权利人:GOULIAEV ALEX HAAHR; FRANCH THOMAS; GODSKESEN MICHAEL ANDERS; JENSEN KIM BIRKEBAEK; NUEVOLUTION AS 摘要:The present invention is directed to a method for the synthesis of a bi-functional complex comprising a molecule part and an identifier oligonucleotide part identifying the molecule part. A part of the synthesis method according to the present invention is preferably conducted in one or more organic solvents when a nascent bi-functional complex comprising an optionally protected tag or oligonucleotide identifier is linked to a solid support, and another part of the synthesis method is preferably conducted under conditions suitable for enzymatic addition of an oligonucleotide tag to a nascent bi-functional complex in solution.
专利号:US-8471006-B2 优先权日:2003-10-31 标题:Coupling agents for peptide synthesis 发明人:CARPINO LOUIS A; XIA JUSONG; ZHANG CHONGWU; SFERDEAN CALIN DAN 权利人:CARPINO LOUIS A; XIA JUSONG; ZHANG CHONGWU; SFERDEAN CALIN DAN; UNIV MASSACHUSETTS 摘要:The present invention is directed to compounds of the formula: n nor salts thereof or N-oxides and their use in peptide synthesis.
专利号:US-9700872-B1 优先权日:2016-07-01 标题:Superpolar chromatographic stationary phases and extraction sorbents and their methods of synthesis 发明人:KABIR ABUZAR; FURTON KENNETH G 权利人:KABIR ABUZAR; FURTON KENNETH G; UNIV FLORIDA INT 摘要:A superpolar sorbent network is a sol-gel network of at least one metal oxide precursor condensed and at least one polyhydroxy molecule. The metal oxide precursor is a silicate precursor, aluminate precursor, titanate precursor, zirconate precursor, germinate precursor, or any combinations thereof, and the polyhydroxy molecule has a multiplicity of hydroxyl groups. The polyhydroxy molecule can be an organic molecule derived from nature. The superpolar sorbent network can be used as a particulate or bulk sorbent for sampling or removal of analytes or contaminants from an environment or can be coated on a tube or particulate substrate for use as a chromatographic stationary phase.
摘要:Spitzner, D., Science of Synthesis Knowledge Updates, (2016) 1, 242. 摘要:A. N. Kost, P. B. Terentev, L. A. Golovleva and A. A. Stolyarchuk, Khim.-Farm. Zh. 1, 3 (1967); CA 68, 29556a.