CAS: 118074-07-0; (2S,3R,4S,6R)-2-(((3R,4S,5S,6R,7R,9R,11R,12R,13S,14R)-14-Ethyl-12,13-Dihydroxy-4-(((2R,4R,5S,6S)-5-Hydroxy-4-Methoxy-4,6-Dimethyltetrahydro-2H-Pyran-2-yl)Oxy)-7-Methoxy-3,5,7,9,11,13-Hexamethyl-2,10-Dioxooxacyclotetradecan-6-yl)Oxy)-3-Hydroxy-N,N,6-Trimethyltetrahydro-2H-Pyran-4-Amine Oxide

英文名称(2S,3R,4S,6R)-2-(((3R,4S,5S,6R,7R,9R,11R,12R,13S,14R)-14-Ethyl-12,13-Dihydroxy-4-(((2R,4R,5S,6S)-5-Hydroxy-4-Methoxy-4,6-Dimethyltetrahydro-2H-Pyran-2-yl)Oxy)-7-Methoxy-3,5,7,9,11,13-Hexamethyl-2,10-Dioxooxacyclotetradecan-6-yl)Oxy)-3-Hydroxy-N,N,6-Trimethyltetrahydro-2H-Pyran-4-Amine Oxide
中文名称克拉霉素N-氧化物
IUPAC名称(2S,3R,4S,6R)-2-(((3R,4S,5S,6R,7R,9R,11R,12R,13S,14R)-14-ethyl-12,13-dihydroxy-4-(((2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyltetrahydro-2H-pyran-2-yl)oxy)-7-methoxy-3,5,7,9,11,13-hexamethyl-2,10-dioxooxacyclotetradecan-6-yl)oxy)-3-hydroxy-N,N,6-trimethyltetrahydro-2H-pyran-4-amine oxide
其它别名Clarithromycin N-Oxide; 6-O-Methylerythromycin N-Oxide; Clarithromycin Impurity Q; Clarithromycin Impurity Q (10 Mg) (N-Oxide Clarithromycin); Clarithromycin Ep Impurity Q; Clarithromycin N-Oxide(Ep Q); Clarithromycin Impurity 17(Clarithromycin Ep Impurity Q); Clarithromycin Nitric Oxide
CAS编号118074-07-0
MFCD编号:MFCD24386630
分子式:C38H69NO14分子量:763.96
产品CID: 231280
产品分类分析化学 → 分析试剂 → 离子色谱试剂

相似结构搜索
InChIKey: KDRPFIWYMNONLJ-KCBOHYOISA-N
InChI=1S/C38H69NO14/c1-15-26-38(10,45)31(42)21(4)28(40)19(2)17-37(9,48-14)33(53-35-29(41)25(39(11,12)46)16-20(3)49-35)22(5)30(23(6)34(44)51-26)52-27-18-36(8,47-13)32(43)2
计算化学: 氢键受体数14.0氢键供体数4.0可旋转键数8.0

MSDS等安全信息

WGK Germany3

上下游产品

erythromycin A N-oxide methyl iodide clarithromycinclarithromycin 50H74O16SC50H74O16S

合成工艺路线路线简述

📜克拉霉素置于双氧水体系中,用甲醇,水用作溶剂,化学反应 15.0H,以92%的收率获得克拉霉素n-氧化物
参考文献: New Macrolides And Their Use[fr] Nouveaux Macrolides Et Leur Utilisation
标题: New Macrolides And Their Use[fr] Nouveaux Macrolides Et Leur Utilisation
摘要:本发明涉及公式(I)的大环内酯化合物,以及所述化合物作为药物的应用,特别是用于治疗或预防炎性和过敏性疾病,包含所述化合物的药物组合物,以及它们的制备过程.本发明特别涉及主要通过抑制磷酸二酯酶4(pde4)介导抗炎活性的大环内酯化合物,这使得它们可用于治疗和/或预防诸如慢性阻塞性肺病(copd),哮喘,类风湿性关节炎,特应性皮炎,炎症性肠病或增殖性疾病,例如癌症等炎性和过敏性疾病.