CAS: 1073-00-3; 2-(2-Methylenecyclopropyl)Acetic Acid

上下游产品

diazomethane methylenecyclopropanecarboxylic acid chloride 2-(methylenecyclopropyl)ethan-1-ol 2-[2-(1-chloro-1-methylcycloprop-2-yl)ethoxy]tetrahydro-2H-pyran spiropentaneacetic acid (1S)-(+)-methylenecyclopropaneacetic acid N-(2-hydroxy-1(R)-phenylethyl)-(S)-(2-methylenecyclopropane)acetamide -(1R)-methylenecyclopropaneacetamideN-(R)-1'-phenyl-2'-hydroxyethyl-(1R)-methylenecyclopropaneacetamide

📜2-(Methylenecyclopropyl)Ethan-1-Ol置于jones Reagent体系中,用 丙酮 用作溶剂,化学反应 1.0H,以70%的收率获得2-亚甲基-环丙烷乙酸
参考文献:螺戊基乙酰辅酶a,一种基于机制的酰基辅酶a脱氢酶灭活剂
标题:螺戊基乙酰辅酶a,一种基于机制的酰基辅酶a脱氢酶灭活剂
摘要:酰基-Coa 脱氢酶 (Acd) 是 Fad 依赖性酶,可催化适当的脂肪酰基-Coa 硫酯底物转化为相应的反式-α,β-烯酰基-Coa 产物.早期研究表明,脱氢是立体有择的,是通过提取 Pro-R α-H 开始的,然后将 Pro-R β-H 作为氢化物等价物转移到结合的 Fad 上.然而,最近关于次甘氨酸 A 的代谢物(亚甲基环丙基)乙酰辅酶 A(mcpa-Coa)使 Acd 失活的研究导致了另一种机制,其中还原当量从最初形成的 α-阴离子传递到结合fad 通过单电子转移过程.为了进一步探索观测到的机制差异,我们重新检查了密切相关的 Mcpa-Coa 类似物的抑制特性,螺戊基乙酰辅酶a(spa-Coa),之前报道为acd的紧密结合抑制剂.与早期结果相反,我们的数据显示 Spa-Coa 是一种基于机制的......
Doi:10.1021/ja9737634

专利信息

专利号:US-11225655-B2
优先权日:2010-04-16
标题:Bi-functional complexes and methods for making and using such complexes
发明人：GOULIAEV ALEX HAAHR; FRANCH THOMAS; GODSKESEN MICHAEL ANDERS; JENSEN KIM BIRKEBAEK
权利人:GOULIAEV ALEX HAAHR; FRANCH THOMAS; GODSKESEN MICHAEL ANDERS; JENSEN KIM BIRKEBAEK; NUEVOLUTION AS
摘要:The present invention is directed to a method for the synthesis of a bi-functional complex comprising a molecule part and an identifier oligonucleotide part identifying the molecule part. A part of the synthesis method according to the present invention is preferably conducted in one or more organic solvents when a nascent bi-functional complex comprising an optionally protected tag or oligonucleotide identifier is linked to a solid support, and another part of the synthesis method is preferably conducted under conditions suitable for enzymatic addition of an oligonucleotide tag to a nascent bi-functional complex in solution.

专利号:EP-1789107-B1
优先权日:2004-08-30
标题 :Medical stent provided with inhibitors of atp synthesis
发明人：POPOWSKI YOURI
权利人:INTERSTITIAL THERAPEUTICS
摘要:The present invention relates to a stent provided with a composition comprising at least one type of inhibitor of ATP synthesis optionally together with at least one inhibitor of the pentose phosphate pathway (PPP) for use in treating stenosis and preventing restenosis in vascular ducts, and for use in treating cancerous tumours present in ducts, resectioned cavities and scars, and for use in treating any disorder arising from the proliferation of cells in ducts or cavities.

专利号:US-2007292478-A1
优先权日:2004-08-30
标 题:Medical Implant Provided with Inhibitors of Atp Synthesis

专利号:WO-2006024488-A2
优先权日:2004-08-30
标题:Medical stent provided with inhibitors of atp synthesis

专利号:US-2009324682-A1
优先权日:2004-08-30
标 题:Medical stent provided with inhibitors of atp synthesis

专利号:EP-1789107-A2
优先权日:2004-08-30
标题:Medical stent provided with inhibitors of atp synthesis