CAS: 10152-76-8; Allyl(Methyl)Sulfane

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CAS号2179-58-0 烯丙基甲基二硫醚 | CAS号3221-15-6 2-(氯甲基)硫杂丙环 | CAS号917-54-4 甲基锂 | CAS号186581-53-3 重氮甲烷 | CAS号870-23-5 烯丙硫醇 | CAS号107-05-1 氯丙烯 | CAS号5188-07-8 甲硫醇钠 | CAS号52670-69-6 2-(9,10-dihydro... | CAS号3877-15-4 甲基丙基硫醚 | CAS号3333-13-9 1-烯丙基-4-甲基苯 | CAS号505-10-2 3-甲硫基丙醇 | CAS号6943-87-9 1-(甲基硫烷基)丙-2-醇 | CAS号27798-45-4 3-(4-叔丁基苯基)-1-丙烯 | CAS号93-15-2 甲基丁香酚, 甲基丁子香酚 | CAS号2181-42-2 三甲基碘代磺酸 | CAS号140-67-0 草蒿脑 | CAS号16215-14-8 烯丙基甲基砜

烯丙基甲基二硫醚置于三苯基膦体系中,用 苯 用作溶剂,化学反应生成烯丙基甲基硫醚
参考文献:Thiosulfoxides. Intermediates In Rearrangement And Reduction Of Allylic Disulfides
标题:Thiosulfoxides. Intermediates In Rearrangement And Reduction Of Allylic Disulfides
摘要:
Doi:10.1021/ja00752A073

专利信息

专利号:US-4459420-A
优先权日:1982-05-17
标题 :Pyrogallol synthesis of anti-atherogenic furochromones
发明人：GAMMILL RONALD B
权利人:UPJOHN CO
摘要:The present invention provides a total synthesis of known intermediates useful in the synthesis of khellin and antiatherosclerotic analogs thereof from pyrogallol. Pyrogallol is converted to 3,6,7-benzofurantriol triacetate using zinc chloride and chloracetanitrile, then catalytically reduced and deactoxylated at the 3 position to yield the corresponding 2,3-dihydrofuran. This substance is subjected to a Fries rearrangement to the corresponding diol, the phenolic hydroxyl group of which is then selectively alkylated. This yields 6-hydroxy-7-alkoxy-5-benzofuranyl methyl ketone, a known intermediate for the production of 4-desmethoxy khellin and analogs thereof. This compound is then selectively alkoxylated at the 4 position using lead tetraacetate or thallium (III) nitrate in an alkanol solvent to yield known chemical intermediates in the preparation of khellin and analogs thereof.

专利号:US-9403854-B2
优先权日:2001-03-30
标 题 :Cross-metathesis reaction of functionalized and substituted olefins using group 8 transition metal carbene complexes as metathesis catalysts
发明人：GRUBBS ROBERT H; CHATTERJEE ARNAB K; CHOI TAE-LIM; GOLDBERG STEVEN D; LOVE JENNIFER A; MORGAN JOHN P; SANDERS DANIEL P; SCHOLL MATTHIAS; TOSTE F DEAN; TRNKA TINA M
权利人:CALIFORNIA INST OF TECHN
摘要:The invention pertains to the use of Group 8 transition metal carbene complexes as catalysts for olefin cross-metathesis reactions. In particular, ruthenium and osmium alkylidene complexes substituted with an N-heterocyclic carbene ligand are used to catalyze cross-metathesis reactions to provide a variety of substituted and functionalized olefins, including phosphonate-substituted olefins, directly halogenated olefins, 1,1,2-trisubstituted olefins, and quaternary allylic olefins. The invention further provides a method for creating functional diversity using the aforementioned complexes to catalyze cross-metathesis reactions of a first olefinic reactant, which may or may not be substituted with a functional group, with each of a plurality of different olefinic reactants, which may or may not be substituted with functional groups, to give a plurality of structurally distinct olefinic products. The methodology of the invention is also useful in facilitating the stereoselective synthesis of 1,2-disubstituted olefins in the cis configuration.

专利号:US-2008287407-A1
优先权日:2003-12-10
标题 :Nitric Oxide Releasing Pyruvate Compounds, Compositions and Methods of Use
发明人：GARVEY DAVID S; FANG XINQIN; KHANAPURE SUBHASH P; RANATUNGA RAMANI R; WEY SHIOW-JYI
权利人:NITROMED INC
摘要:The invention describes novel nitrosated and/or nitrosylated pyruvate compounds and pharmaceutically acceptable salts thereof, and novel compositions comprising at least one nitrosated and/or nitrosylated pyruvate compound, and, optionally, at least one compound that donates, transfers or releases nitric oxide, stimulates endogenous synthesis of nitric oxide, elevates endogenous levels of endothelium-derived relaxing factor or is a substrate for nitric oxide synthase, and/or at least one therapeutic agent. The invention also provides novel compositions comprising at least one pyruvate compound and at least one compound that donates, transfers or releases nitric oxide, elevates endogenous levels of endothelium-derived relaxing factor, stimulates endogenous synthesis of nitric oxide or is a substrate for nitric oxide synthase and/or at least one therapeutic agent. The invention also provides novel kits comprising at least one pyruvate compound, that is optionally nitrosated and/or nitrosylated, and, optionally, at least one nitric oxide donor and/or at least one therapeutic agent. The invention also provides methods for treating diseases resulting from oxidative stress, diabetes, reperfusion injury following ischemia, preservation of tissues, organs, organ parts and/or limbs.

专利号:US-2012149888-A1
优先权日:2009-02-22
标 题:Synthesis of ara-2'-o-methyl-nucleosides, corresponding phosphoramidites and oligonucleotides incorporating novel modifications for biological application in therapeuctics, diagnostics, g- tetrad forming oligonucleotides and aptamers
发明人：SRIVASTAVA SURESH C; PANDEY DIVYA; SRIVASTAVA NAVEEN P; SRIVASTAVA ALOK
权利人:SRIVASTAVA SURESH C; PANDEY DIVYA; SRIVASTAVA NAVEEN P; SRIVASTAVA ALOK
摘要:The present invention relates to synthesis, purification and methods to obtain high purity novel 2′-arabino-O-methyl nucleosides and the corresponding phosphoramidites of various arabinonucleoside bases and introduction of such units into defined sequence synthetic DNA and RNA. Various synthetic oligonucleotides, such as HIV integrase inhibitor 14-mer and thrombin binding oligonucleotide, thrombin-1, bearing ara-2′-omethyl modification have been synthesized. It is anticipated the oligonucleotides incorporating these monomers will exhibit biological activities related to antisense approach approach, design of better SiRNA's, diagnostic agents. Similarly, it is anticipated that oligonucleotides incorporating such novel nucleosides will be useful to develop therapeutic candidates designing stable G-quadruplexes and Aptamers for oligonucleotide structure, folding topology, evaluation of biochemical properties and design and develop as therapeutic agents. It is further anticipated that the nucleosides, phosphates and triphosphates of this invention could develop as therapeutic agents.

专利号:US-2004110228-A1
优先权日:2002-04-01
标 题:Combinatorial organic synthesis of unique biologically active compounds
发明人：MCALPINE SHELLI R; TAYLOR RACHEL E; BOLLA MEGAN L; SEGALL ANCA M
摘要:The invention provides a method for making a combinatorial library of cyclic compounds, such as Holliday junction-trapping compounds, comprising the steps of (a) obtaining a plurality of trimers according to the generic structure X 1- X 2- X 3 , wherein X 1 , X 2 and X 3 can be independently any naturally or nonnaturally occurring amino acids or peptidomimetics thereof; (b) optionally coupling a spacer S to the trimer at either end; (c) cyclizing two trimers or trimer-spacer conjugates in a head-to-tail orientation; thereby obtaining a combinatorial library of compounds, wherein the library does not include an unmodifed or naturally occurring Holliday Junction-trapping compounds. The invention additionally provides methods macrocyclic compounds that are synergimycin derivatives.

专利号:US-5783577-A
优先权日:1995-09-15
标题 :Synthesis of quinazolinone libraries and derivatives thereof
发明人：HOUGHTEN RICHARD A; OSTRESH JOHN M
权利人:TREGA BIOSCIENCES INC
摘要:The present invention provides synthetic combinatorial libraries of organic compounds based on the quinazolinone ring.