CAS: 87-05-8; 7-Ethoxy-4-Methylcoumarin

该化合物是一种作为荧光探测器和有机合成中间体广泛使用的合成丙胺衍生物,其主要优点包括具有很强的荧光特性,对紫外光光探测和荧光标签等分析应用具有价值;乙氧和甲基替代成分增强了其在有机溶剂中的可光性和溶性,促进了其在研究和工业过程中的使用;该化合物还作为合成更复杂的丙胺分子的前体,这些分子用于制药,染料和光学照明器,其特性精良的再活性和稳定性在各种条件下进一步有助于其在化学和生物化学研究中的用途.

⚠️《化妆品禁用原料目录》
英文名称7-Ethoxy-4-Methylcoumarin
中文名称7-乙氧基-4-甲基香豆素
IUPAC名称7-ethoxy-4-methylchromen-2-one
其它别名7-Ethoxy-4-methylcoumarin; Ethyl 4-methylumbelliferyl ether
CAS编号87-05-8
MFCD编号:MFCD00016971
EINECS号:201-721-5
FDA UNII编号:ZLV1S0NNZH
分子式:C12H12O3
分子量:204.22
产品CID: 2389878
产品分类生物化工 → 提取物

相似结构搜索
InChIKey: NKRISXMDKXBVRJ-UHFFFAOYSA-N
InChI=1S/C12H12O3/c1-3-14-9-4-5-10-8(2)6-12(13)15-11(10)7-9/h4-7H,3H2,1-2H3…
计算化学: 氢键受体数3.0氢键供体数0.0可旋转键数2.0

MSDS等安全信息

GHS符号GHS07
警示词Warning
危险描述H302+H312+H332-H319-H335
防范说明P261-P271-P280
UN编号NONH for all modes of transport
危险品标志Xi
风险等级Irritant
安全声明24/25
WGK Germany3.0

上下游产品

合成工艺路线路线简述

90-33-5 = 87-05-8
反应条件:1.1 Reagents: Potassium Carbonate Solvents: Acetone; 10 Min,Reflux1.2 6 H,Reflux
标题:The Synthesis Of Novel Coumarin Dyes And The Study Of Their Photoreaction Properties
作者:Wang,Tao; Et Al
参考文献:Dyes And Pigments 日期:2007 卷标:75(1) 页码:104-110]

621-34-1 + 3952-66-7 = 87-05-8
反应条件:1.1 Catalysts: Selectfluor; 30 Min,Rt
标题:Selectfluor-Promoted Environmental-Friendly Synthesis Of 2H-Chromen-2-One Derivative Under Various Reaction Conditions
作者:Ranjbar-Karimi,R.; Et Al
参考文献:Journal Of The Iranian Chemical Society 日期:2011 卷标:8(1) 页码:193-197]

90-33-5 = 87-05-8
反应条件:1.1 Reagents: Potassium Hydroxide Catalysts: Tetrabutylammonium Bromide Solvents: Acetone; 20 Min,45 - 55 °C
标题:Study On Synthesis Of 7-Ethoxyl-4-Methycoumarin By Phase Transfer Catalysis Under Microwave Irradiation
作者:Ye,Hong; Et Al
参考文献:Huaxue Shijie 日期:2014 卷标:55(4) 页码:223-225]

90-33-5 = 87-05-8 [标题:Reaction Conditions
标题:One-Pot Synthesis And Photophysical Studies Of Dihydropyrimidinone-Based Dyes: Novel Violet-Blue Light Emitting Fluorophores
作者:Matta,Akanksha; Et Al
参考文献:Chemistryselect 日期:2018 卷标:3(38) 页码:10815-10820]

105-45-3 = 87-05-8
反应条件:1.1 Catalysts: Sulfuric Acid Solvents: Tetrahydrofuran; 0.5 H,< 10 °C; 4 - 5 H2.1 Reagents: Potassium Carbonate Solvents: Tetrahydrofuran; 15 Min,Rt; 15 Min,Rt2.2 10 D,Rt
标题:Synthesis,Antifungal,And Phytotoxic Effects Of Some Benzopyrone Derivatives
作者:Khan,Khalid Mohammed; Et Al
参考文献:Natural Product Research 日期:2004 卷标:18(1) 页码:21-27]

105-45-3 = 87-05-8
反应条件:1.1 Reagents: Sulfuric Acid Solvents: Tetrahydrofuran; 5 H,10 °C -> Rt2.1 Reagents: Potassium Carbonate Solvents: Tetrahydrofuran; 24 H,Reflux
标题:Synthesis And Biological Screening Of 7-Hydroxy-4-Methyl-2H-Chromen-2-One,7-Hydroxy-4,5-Dimethyl-2H-Chromen-2-One And Their Some Derivatives
作者:Khan,Khalid Mohammed; Et Al
参考文献:Natural Product Research 日期:2003 卷标:17(2) 页码:115-125]

141-97-9 = 87-05-8
反应条件:1.1 Catalysts: Sulfuric Acid; 6 - 8 H,Rt2.1 Reagents: Potassium Carbonate Solvents: Acetone; 12 H,Reflux
标题:Synthesis,Characterisation And Photophysical Studies Of Oxadiazolyl Coumarin: A New Class Of Blue Light Emitting Fluorescent Dyes
作者:Matta,Akanksha; Et Al
参考文献:Dyes And Pigments 日期:2017 卷标:140 页码:250-260]

1522-29-8 = 87-05-8
反应条件:1.1 Reagents: Sulfuric Acid; < 10 °C; 24 H,0 °C1.2 Reagents: Sodium Hydroxide Solvents: Water1.3 Reagents: Sulfuric Acid Solvents: Water; Acidified2.1 Reagents: Potassium Carbonate Solvents: Acetone
标题:Synthesis And Antibacterial Activity Of Mannich Bases Of Coumarins
作者:Sumakanth,M.; Et Al
参考文献:European Journal Of Biomedical And Pharmaceutical Sciences 日期:2019 卷标:6(8) 页码:288-294]

541-50-4 = 87-05-8
反应条件:1.1 Reagents: Sulfuric Acid Solvents: 1,4-Dioxane; Rt; 6 H,60 °C2.1 Reagents: Potassium Carbonate Solvents: Acetone; 10 Min,Reflux2.2 6 H,Reflux
标题:The Synthesis Of Novel Coumarin Dyes And The Study Of Their Photoreaction Properties
作者:Wang,Tao; Et Al
参考文献:Dyes And Pigments 日期:2007 卷标:75(1) 页码:104-110]

621-34-1 + 105-45-3 = 87-05-8
反应条件:1.1 Reagents: Borane,Trifluoro-,Dihydrate; 20 Min,60 °C
标题:Pechmann Reaction Promoted By Boron Trifluoride Dihydrate
作者:Stoyanov,Edmont V.; Et Al
参考文献:Molecules 日期:2005 卷标:10(7) 页码:762-766]

90-33-5 = 87-05-8
反应条件:1.1 Reagents: Potassium Carbonate Solvents: Acetonitrile; 48 H,60 °C
标题:En Route To Stabilized Compact Conformations Of Single-Chain Polymeric Nanoparticles In Complex Media
作者:Wijker,Stefan; Et Al
参考文献:Macromolecules (Washington 日期:2022 卷标:55(14) 页码:6220-6230]

90-33-5 = 87-05-8
反应条件:1.1 Reagents: Potassium Carbonate Solvents: Acetone; 3 H,Reflux
标题:Synthesis,Characterization And Antibacterial Activity Of Coumarin Derivatives
作者:Sukanya,M.; Et Al
参考文献:World Journal Of Pharmacy And Pharmaceutical Sciences 日期:2019 卷标:8(3) 页码:1574-1589]

90-33-5 = 87-05-8
反应条件:1.1 Solvents: Methanol
标题:Polymer Supported Hydroxycoumarin Anion. Convenient Method For O-Alkylation Of Hydroxycoumarin
作者:Deshmukh,J. G.; Et Al
参考文献:Journal Of The Indian Chemical Society 日期:1986 卷标:63(4) 页码:442-3]

621-34-1 + 6283-75-6 = 87-05-8
反应条件:1.1 Catalysts: Chlorosulfonic Acid (Reaction Products With Cellulose),Cellulose (Reaction Products With Chlorosulfonic Acid); 2 Min
标题:Expeditious Pechmann Condensation By Using Biodegradable Cellulose Sulfuric Acid As A Solid Acid Catalyst
作者:Kuarm,B. Suresh; Et Al
参考文献:Synthetic Communications 日期:2010 卷标:40(22) 页码:3358-3364]

141-97-9 + 621-34-1 = 87-05-8
反应条件:1.1 Catalysts: Xanthan Gum,Hydrogen Sulfate; 25 Min,Rt
标题:Xanthan Sulfuric Acid,An Efficient And Recyclable Solid Acid Catalyst For Pechmann Condensation
作者:Kuarm,B. Suresh; Et Al
参考文献:Synthetic Communications 日期:2012 卷标:42(12) 页码:1770-1777]

141-97-9 + 621-34-1 = 87-05-8
反应条件:1.1 Catalysts: Cupric Perchlorate; 35 Min,45 - 50 °C
标题:Ultrasound-Promoted Greener Synthesis Of 2H-Chromen-2-Ones Catalyzed By Copper Perchlorate In Solventless Media
作者:Puri,Saurabh; Et Al
参考文献:Ultrasonics Sonochemistry 日期:2009 卷标:16(6) 页码:705-707]

141-97-9 + 621-34-1 = 87-05-8
反应条件:1.1 Catalysts: Lithium Bromide; 20 Min,75 °C
标题:Libr-Mediated,Solvent Free Von Pechmann Reaction: Facile And Efficient Method For The Synthesis Of 2H-Chromen-2-Ones
作者:Kumar,Sanjay; Et Al
参考文献:Arkivoc (Gainesville 日期:2007 卷标:(15) 页码:18-23]

90-33-5 = 87-05-8
反应条件:1.1 Reagents: Potassium Carbonate,Tetrabutylammonium Bromide,Potassium Iodide Solvents: Acetone; 5 H,80 °C
标题:Catalytic Synthesis Of 7-Alkoxylcoumarins By Tbab
作者:Zhang,Wei-Hua; Et Al
参考文献:Hecheng Huaxue 日期:2008 卷标:16(5) 页码:561-563]

90-33-5 = 87-05-8
反应条件:1.1 Reagents: Potassium Carbonate Solvents: Acetonitrile; Overnight,80 °C
标题:Coumarin Derivatives As Substrate Probes Of Mammalian Cytochromes P450 2B4 And 2B6: Assessing The Importance Of 7-Alkoxy Chain Length,Halogen Substitution,And Non-Active Site Mutations
作者:Liu,Jingbao; Et Al
参考文献:Biochemistry 日期:2016 卷标:55(13) 页码:1997-2007]

90-33-5 = 87-05-8
反应条件:1.1 Reagents: Potassium Carbonate Solvents: Acetone; 12 H,Reflux
标题:Synthesis,Characterisation And Photophysical Studies Of Oxadiazolyl Coumarin: A New Class Of Blue Light Emitting Fluorescent Dyes
作者:Matta,Akanksha; Et Al
参考文献:Dyes And Pigments 日期:2017 卷标:140 页码:250-260]

105-45-3 = 87-05-8
反应条件:1.1 Reagents: Sulfuric Acid Solvents: Tetrahydrofuran; 30 Min,Rt; 4 - 5 H,Rt2.1 Solvents: Tetrahydrofuran; 15 Min,Rt2.2 Reagents: Potassium Hydroxide; 15 Min,Rt2.3 24 H,Reflux
标题:Synthesis,Antioxidant And Insecticidal Activities Of Some Coumarin Derivatives
作者:Khan,K. M.; Et Al
参考文献:Journal Of The Chemical Society Of Pakistan 日期:2002 卷标:24(3) 页码:226-231]

141-97-9 = 87-05-8
反应条件:1.1 Catalysts: Sulfuric Acid Solvents: Water; 24 H,10 - 25 °C2.1 Catalysts: Potassium Carbonate Solvents: Acetone; 10 Min,Reflux2.2 18 H,56 °C
标题:Synthesis Of 6- And 7-Alkoxy-4-Methylcoumarins From Corresponding Hydroxy Coumarins And Their Conversion Into 6- And 7-Alkoxy-4-Formylcoumarin Derivatives
作者:Ngoc Toan,Vu; Et Al
参考文献:Synthetic Communications 日期:2020 卷标:50(23) 页码:3603-3615]

141-97-9 = 87-05-8
反应条件:1.1 Reagents: Sulfuric Acid2.1 Reagents: Potassium Carbonate Solvents: Acetone
标题:Antimicrobial Prospection Of Some Coumarin Derivatives
作者:Taataringa,Gabriela; Et Al
参考文献:Farmacia (Bucharest 日期:2018 卷标:66(2) 页码:323-330]

1522-29-8 = 87-05-8
反应条件:1.1 Reagents: Sulfuric Acid; < 10 °C; 12 H,< 10 °C1.2 Reagents: Sodium Hydroxide Solvents: Water; Rt1.3 Reagents: Sulfuric Acid Solvents: Water; 10 Min,Acidified,Rt2.1 Reagents: Potassium Carbonate Solvents: Acetone; 3 H,Reflux
标题:Synthesis,Characterization And Antibacterial Activity Of Coumarin Derivatives
作者:Sukanya,M.; Et Al
参考文献:World Journal Of Pharmacy And Pharmaceutical Sciences 日期:2019 卷标:8(3) 页码:1574-1589]

91497-31-3 = 87-05-8
反应条件:1.1 Reagents: Sodium Hydroxide Solvents: Water; Rt1.2 Reagents: Sulfuric Acid Solvents: Water; 10 Min,Acidified,Rt2.1 Reagents: Potassium Carbonate Solvents: Acetone; 3 H,Reflux
标题:Synthesis,Characterization And Antibacterial Activity Of Coumarin Derivatives
作者:Sukanya,M.; Et Al
参考文献:World Journal Of Pharmacy And Pharmaceutical Sciences 日期:2019 卷标:8(3) 页码:1574-1589]

91497-31-3 = 87-05-8
反应条件:1.1 Reagents: Sodium Hydroxide Solvents: Water1.2 Reagents: Sulfuric Acid Solvents: Water; Acidified2.1 Reagents: Potassium Carbonate Solvents: Acetone
标题:Synthesis And Antibacterial Activity Of Mannich Bases Of Coumarins
作者:Sumakanth,M.; Et Al
参考文献:European Journal Of Biomedical And Pharmaceutical Sciences 日期:2019 卷标:6(8) 页码:288-294]

= 87-05-8 + 897-83-6
反应条件:1.1 Solvents: Methanol,Chloroform
标题:Photochemistry Of Pesticides. 13. Some Photoreactions Of O,O-Diethyl-O-(4-Methyl-2-Oxo-2H-1-Benzopyran-7-Yl)Phosphorothioate (Potasan)
作者:Abdou,Wafaa M.; Et Al
参考文献:Phosphorus And Sulfur And The Related Elements 日期:1988 卷标:39(3-4) 页码:199-203

3-甲氧基苯酚置于硫酸,Potassium Carbonate体系中,用丙酮作为反应溶剂,化学反应 42.0H,反应生成 7-乙氧基-4-甲基香豆素
参考文献:从相应的羟基香豆素合成 6-和 7-烷氧基-4-甲基香豆素及其转化为 6-和 7-烷氧基-4-甲酰基香豆素衍生物
标题:从相应的羟基香豆素合成 6-和 7-烷氧基-4-甲基香豆素及其转化为 6-和 7-烷氧基-4-甲酰基香豆素衍生物
摘要:摘要以对苯二酚和间苯二酚与乙酰乙酸乙酯反应制备了4-甲基-2H-色烯-2-酮的羟基衍生物.然后通过与烷基卤反应将这些羟基香豆素转化为相应的烷氧基衍生物.6-和7-烷氧基-4-甲基香豆素3A-I 和4A-I 的产率为55-95%.在常规和微波辅助加热条件下用二氧化硒氧化这些化合物产生相应的 4-甲酰基化合物 5B-H 和 6B-H,产率分别为 40-67% 和 90-93%.几种 6-和 7-烷氧基-4-甲基香豆素 3A-I,4A-I 以及几乎所有 6-和 7-烷氧基-4-甲酰基香豆素 5B-H,6B-H 都是新化合物.图形概要
DOI:10.1080/00397911.2020.1807571

海关参考信息

2908199090-其他酚的卤化衍生物
2908999090-其他酚的硝化衍生物
2918290000-其他含酚基羧酸
2901100000-饱和无环烃
💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
详情请参考：📖 海关编码查询和海关进出口税则

专利信息

专利号:US-2013004979-A1
优先权日:2010-06-11
标题 :Glycosyltransferase reversibility for sugar nucleotide synthesis and microscale scanning
发明人：THORSON JON S; GANTT RICHARD W; PELTIER-PAIN PAULINE MARIE JEANNE
权利人:WISCONSIN ALUMNI RES FOUND; THORSON JON S; GANTT RICHARD W; PELTIER-PAIN PAULINE MARIE JEANNE
摘要:The present invention generally relates to materials and methods for exploiting glycosyltransferase reversibility for nucleotide diphosphate (NDP) sugar synthesis. The present invention provides engineered glycosyltransferase enzymes characterized by improved reaction reversibility and expanded sugar donor specificity as compared to corresponding non-mutated glycosyltransferase enzymes. Such reagents provide advantageous routes to NDP sugars for subsequent use in a variety of biomedical applications, including enzymatic and chemo-enzymatic glycorandomization.

专利号:US-2006251786-A1
优先权日:2005-04-19
标题:Cyclopropanated coumarin derivatives
发明人：TURIN LUCA
权利人:TURIN LUCA
摘要:This invention provides compound or a mixture of compounds of formula (I): n n nwherein R and R 1 are independently a substituted or unsubstituted, straight or branched alkyl or alkoxy group having up to 5 carbons, phenyl or substituted phenyl; R 2 and R 3 are each independently H or CH 3 ; m is an integer from 0 to 4, and n is an integer from 0 to 2. A method for the synthesis of these compounds is also provided, as is their use as aromachemicals and flavorants and compositions, products and articles containing them.