CAS: 65192-28-1; 2-(4-Methoxyphenyl)Malonaldehyde

上下游产品

4-Methoxyphenylacetic acid 4-methoxybenzoic acid H-pyrimidin-2-one5-(4-methoxy-phenyl)-1-methyl-1H-pyrimidin-2-one 2-chloro-5-(4-methoxyphenyl)pyrimidine 1-(3,4-methylenedioxyphenyl)-2-[5-(4-methoxyphenyl)-pyrimidin-2-yl]-2,3,4,9-tetrahydro-1H-β-carboline 1-(2,3-dihydro-benzofuran-5-yl)-2-[5-(4-methoxy-phenyl)-pyrimidin-2-yl]-2,3,4-9-tetrahydro-1H-β-carboline

📜对甲氧基苯乙酸置于sodium Perchlorate Monohydrate,Sodium Hydroxide,三氯氧磷体系中,用 水 作为反应溶剂,化学反应 0.25H,反应生成 4-甲基磺酰苄胺
参考文献:新型4-吡唑基-1,8-萘二甲酰亚胺衍生物的合成,抗癌活性和dna结合特性
标题:新型4-吡唑基-1,8-萘二甲酰亚胺衍生物的合成,抗癌活性和dna结合特性
摘要:已经设计并容易地合成了一系列新颖的4-吡唑基-1,8-萘二甲酰亚胺衍生物.对于体外抗癌活性,发现大多数化合物对人乳腺癌细胞(mcf-7)的毒性比人宫颈癌细胞(hela)和人肺癌细胞(a549)高.化合物4I,4H,4B和4A与阿莫那肽相比对mcf-7细胞表现出改善的细胞毒活性,尤其是化合物4I和4H,其对mcf-7细胞系的ic 50值分别为0.51μm和0.79μm .4I的dna结合特性通过紫外可见光谱,荧光和圆二色性(cd)光谱学和热变性进行了研究.结果表明,作为dna嵌入剂的化合物4I显示出与ct-Dna的中等结合亲和力.
DOI:10.1016/j.Bmcl.2013.12.014

专利信息

专利号:US-6891069-B1
优先权日:2004-01-30
标 题:Synthesis of 4-substituted phthalaldehyde
发明人：ZHU PETER C; WANG DER-HAW
权利人:ETHICON INC
摘要:Disclosed herein are methods of synthesizing a 4-substituted-benzene-1,2-carbaldehyde. In one aspect, a method may include reacting a 4-substituted-1,2-bis(dibromomethyl) benzene with sulfuric acid to form a reaction product, introducing a solid sodium bicarbonate into the reaction product, and hydrolyzing the reaction product to form a 4-substituted-benzene-1,2-carbaldehyde, after introducing the bicarbonate.

专利号:US-11225655-B2
优先权日:2010-04-16
标题:Bi-functional complexes and methods for making and using such complexes
发明人：GOULIAEV ALEX HAAHR; FRANCH THOMAS; GODSKESEN MICHAEL ANDERS; JENSEN KIM BIRKEBAEK
权利人:GOULIAEV ALEX HAAHR; FRANCH THOMAS; GODSKESEN MICHAEL ANDERS; JENSEN KIM BIRKEBAEK; NUEVOLUTION AS
摘要:The present invention is directed to a method for the synthesis of a bi-functional complex comprising a molecule part and an identifier oligonucleotide part identifying the molecule part. A part of the synthesis method according to the present invention is preferably conducted in one or more organic solvents when a nascent bi-functional complex comprising an optionally protected tag or oligonucleotide identifier is linked to a solid support, and another part of the synthesis method is preferably conducted under conditions suitable for enzymatic addition of an oligonucleotide tag to a nascent bi-functional complex in solution.

专利号:US-7476767-B2
优先权日:2004-01-30
标题:Alpha-hydroxy sulfonate aldehydes, germicidal compositions containing the alpha-hydroxy sulfonate aldehydes, or mixtures of alpha-hydroxy sulfonate aldehydes and phthalaldehydes, and methods of using the compounds or compositions for disinfection or sterilization
发明人：ZHU PETER C; ROBERTS CHARLES G; TRAN YVONNE
权利人:ETHICON INC
摘要:Disclosed herein are α-Hydroxy sulfonate aldehydes and synthesis methods therefor. Germicidal compositions including the α-hydroxy sulfonate aldehydes, are also disclosed. In one aspect, a germicidal composition may include a diluent, and a germicidally effective amount of a water-soluble germicidal compound including an aldehyde group and an α-hydroxy sulfonate group. The water-soluble compound may have a solubility of at least 5 (w/v) % in water. In a further aspect, the compound may include 1-hydroxy-3-oxo-2-phenyl-propane-1-sulfonic acid salt, (2-formyl-phenyl)-hydroxy-methane sulfonic acid salt, 1-hydroxy-2-(4-methanesulfonyl-2-nitro-phenyl)-3-oxo-propane-1-sulfonic acid salt, 2-bromo-1-hydroxy-3-oxo-propane-1-sulfonic acid salt, 2-chloro-1-hydroxy-3-oxo-propane-1-sulfonic acid salt, 2-(1-formyl-2-hydroxy-2-sulfo-ethyl)-isonicotinic acid salt, 2-benzooxazol-2-yl-1-hydroxy-3-oxo-propane-1-sulfonic acid salt, or 1-hydroxy-2-(4-methoxy-phenyl)-3-oxo-propane-1-sulfonic acid salt. Germicidal compositions including a mixture of an α-hydroxy sulfonate aldehyde and one or more phthalaldehydes, such as phthalaldehyde, isophthalaldehyde, terephthalaldehyde, or a combination thereof, are also disclosed. Methods of using the compounds or compositions for killing bacteria, disinfection, or sterilization, are also disclosed.

专利号:EP-1559704-A1
优先权日:2004-01-30
标 题 :Synthesis of 4-substituted phthalaldehyde