CAS: 63628-25-1; 2-Methoxy-2-(Naphthalen-1-yl)Propanoic Acid

该化合物是一种有机化合物,其独特的结构特征包括一个环烷基和附属于丙诺酸脊柱的甲氧基组;该化合物通常具有以下特性:在室温下固态,由于存在缺水性(纳phele)和缺水性(cboxylen-1-yl)功能组,有机溶剂中具有中等溶解性;甲氧基组因其结构特征和潜在用途,在医药化学和材料科学等领域具有再活性和形成氢结,影响其化学行为和相互作用.

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相似化合物

63628-26-2 102691-93-0 2006277-95-6

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CAS号63628-26-2 (R)-(-)-2-甲氧基-2... | CAS号102691-93-0 (S)-(+)-2-甲氧基-2...

合成工艺路线路线简述

    📜Rac-Methyl 2-Hydroxy-2-(1-Naphthyl)Propionate置于sodium Hydride,Potassium Hydroxide体系中,用 四氢呋喃,甲醇,水 作为反应溶剂,化学反应生成 2-甲氧基-2-(1-萘基)丙酸
    参考文献:使用手性苯乙胺与非对映异构体形成对映体,对2-甲氧基-2-(1-萘基)丙酸进行对映拆分
    标题:使用手性苯乙胺与非对映异构体形成对映体,对2-甲氧基-2-(1-萘基)丙酸进行对映拆分
    摘要:使用非对映体盐与手性(R)-苯乙胺对映体分离2-甲氧基-2-(1-萘基)丙酸(mαnp酸),得到对映纯(R)-Mαnp酸,收率29%,> 99% Ee基于rac-Mαnp酸.非对映异构体盐的x射线晶体分析表明,(R)-Mαnp酸紧密排列,由四个独立的氢键和与(R)-苯乙胺的一个ch-π相互作用.
    DOI:10.1016/j.Tetlet.2014.05.037

    海关参考信息

    专利信息


    专利号:US-10000432-B2
    优先权日:2014-01-13
    标 题 :Processes for the synthesis of chiral 1-alkanols
    发明人：NEGISHI EI-ICHI
    权利人:PURDUE RESEARCH FOUNDATION
    摘要:The invention relates to highly enantioselective processes for the synthesis of chiral 1-alkanols via Zr-catalyzed asymmetric carboalumination of alkenes.

    专利号:US-9428482-B2
    优先权日:2011-01-27
    标 题 :Process for synthesis of polyphenols
    发明人：DUGAR SUNDEEP; MAHAJAN DINESH; PANTELIS PETER GIANNOUSIS; SINGH VIJAY; KAPOOR KAMAL KISHORE
    权利人:DUGAR SUNDEEP; MAHAJAN DINESH; PANTELIS PETER GIANNOUSIS; SINGH VIJAY; KAPOOR KAMAL KISHORE; SPHAERA PHARMA PTE LTD
    摘要:The present invention provides synthetic processes for preparing racemic and/or optically pure epicatechin, epigallocatechin and related polyphenols as such or as their variously functionalized derivatives. A principle objective of the disclosure is to provide a new and useful method of synthesis to obtain polyphenols in isomerically pure and/or racemic forms.

    专利号:EP-3094613-A1
    优先权日:2014-01-13
    标题:Processes for the synthesis of chiral 1-alkanols

    专利号:US-2014031421-A1
    优先权日:2011-01-27
    标 题 :Novel process for synthesis of polyphenols

    专利号:EP-2668176-A2
    优先权日:2011-01-27
    标 题:A novel process for synthesis of polyphenols

    专利号:EP-2668176-B1
    优先权日:2011-01-27
    标 题 :A novel process for synthesis of polyphenols

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    主要参考文献

    参考标题:Enantioselective Synthesis Of Chiral Isotopomers Of 1-Alkanols By A Zaca-Cu-Catalyzed Cross-Coupling Protocol
    作者:Shiqing Xu,Akimichi Oda,Ei-Ichi Negishi |发布日期:2014.12.1
    摘要:Chiral Compounds Have A Non‐measurable Specific Rotation, Owing To Very Small Differences Between The Isotopomeric Groups, And Exhibit Cryptochirality. This Particular Class Of Compounds Is Difficult To Synthesize And Characterize. Herein, We Present A Catalytic And Highly Enantioselective Conversion Of Terminal Alkenes To Various β And More Remote Chiral Isotopomers Of 1‐alkanols, With >=99 % Enantiomeric

    合成参考文献


    参考文献:10.1021/acs.jafc.6b03670
    摘要:Kiske C, Nörenberg S, Ecker M, Ma X, Taniguchi T, Monde K, Eisenreich W, Engel KH. Reinvestigation of the Absolute Configurations of Chiral β-Mercaptoalkanones Using Vibrational Circular Dichroism and 1H NMR Analysis. J Agric Food Chem. 2016 Nov 16;64(45):8563–71. doi: 10.1021/acs.jafc.6b03670.
    参考文献:10.1002/chir.20156
    摘要:Kosaka M, Sekiguchi S, Naito J, Uemura M, Kuwahara S, Watanabe M, Harada N, Hiroi K. Synthesis of enantiopure phthalides including 3-butylphthalide, a fragrance component of celery oil, and determination of their absolute configurations. Chirality. 2005 May 05;17(4):218–32. doi: 10.1002/chir.20156.
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