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📜2-(羟基甲基)-5-甲氧基-4H-吡喃-4-酮置于jones Reagent,氨体系中,用 N-甲基吡咯烷酮,乙醇,水,丙酮 作为反应溶剂,化学反应 12.67H,反应生成 (9CI)-3-甲氧基-4-羟基吡啶
参考文献:Systematic Comparison Of The Mono-,Dimethyl-And Trimethyl 3-Hydroxy-4(1H)-Pyridones-Attempted Optimization Of The Orally Active Iron Chelator,Deferiprone
标题:Systematic Comparison Of The Mono-,Dimethyl-And Trimethyl 3-Hydroxy-4(1H)-Pyridones-Attempted Optimization Of The Orally Active Iron Chelator,Deferiprone
摘要:A Range Of Close Analogues Of Deferiprone Have Been Synthesised. The Group Includes Mono-,Di-And Trimethyl-3-Hydroxy-4(1H)-Pyridones. These Compounds Were Found To Possess Similar Pfe(3+) Values To That Of Deferiprone,With The Exception Of The 2.5-Dimethylated Derivatives. Surprisingly The Nh-Containing Hydroxy-4(1H)-Pyridones Were Found To Be Marginally More Lipophilic Than The Corresponding N-Me Containing Analogues. This Same Group Are Also Metabolised Less Efficiently By Phase 1 Hydroxylating Enzymes Than The Corresponding N-Me Analogues.As Result Of This Study,Three Compounds Have Been Identified For Further Investigation Centred On Neutropenia And Agranulocytosis. (C) 2016 Elsevier Masson Sas. All Rights Reserved.
DOI:10.1016/j.Ejmech.2016.03.014