溶剂黄146置于氯,三氯化磷体系中,化学反应生成 三氯乙酸甲酯 参考文献:Process For Preparing A Mixture Of Trichloroacetic Derivatives And Reaction Products Thereof 标题:Process For Preparing A Mixture Of Trichloroacetic Derivatives And Reaction Products Thereof
专利号:WO-2021014395-A1 优先权日:2019-07-24 标题:Process for the synthesis of deuterated capsaicin, capsaicinoids and synthetic capsaicin analogs 发明人:ORUGANTI SRINIVAS; AMRUTAPU SRAVANTH KUMAR; SAMPATH MAGESH; SEN SAIKAT 权利人:DR REDDY’S INST OF LIFE SCIENCES 摘要:The present application provides novel processes for the synthesis of deuterated intermediates of capsaicinoids, particularly II, III, IV and V of capsaicinoids, relating to pharmaceutical applications. The invention also provides novel intermediates of compounds of formula IX, XIV, XV, XVI, XVII, XVIII, XX and XXI utilized in the process of making deuterated capsaicin II, III, IV and V.
专利号:WO-2020255049-A1 优先权日:2019-06-20 标题:Process for the preparation and identification of deuterated eugenol 发明人:ORUGANTI SRINIVAS; AMRUTAPU SRAVANTH KUMAR; SAMPATH MAGESH; SEN SAIKAT 权利人:DR REDDY’S INST OF LIFE SCIENCES 摘要:The present invention provides a novel, simple, unique and viable processes for the synthesis of deuterium incorporated eugenols, such as deuterated eugenol (II), regioisomeric deuterated eugenol (III), and deuterated variant of methyl eugenol (V).
专利号:US-7084281-B2 优先权日:2003-01-22 标题:Synthesis of dihalohydrins and tri- and tetra-substituted olefins 发明人:FALCK JOHN R; BARMA DEB K; KUNDU ABHIJIT 权利人:UNIV TEXAS 摘要:A novel synthesis reaction for highly stereospecific tri- and tetra-substituted olefins is described. A single stereoisomer of stable α-halo-α,β-ester is produced in high yield by the reaction of aldehyde or ketone with a trihalogenated compound such as trichloroacetate in the presence of CrCl 2 in a solvent. By varying the amount of CrCl 2 used, the stable dihalohydrin intermediate may be obtained as well.
专利号:US-5194602-A 优先权日:1988-04-08 标题 :9α-hydroxy-17-methylene steroids, process for their preparation and their use in the preparation of corticosteroids 发明人:BATISI JACOBUS N M; MARX ARTHUR F 权利人:GIST BROCADES NV 摘要:New 9α-hydroxy-17-methylene steroids are prepared by the introduction of a substituted 17-methylene group in 9α-hydroxyandrost-4-ene-3, 17-dione. n The resulting compounds are useful starting compounds in the synthesis of corticosteroids.
专利号:US-4341706-A 优先权日:1980-10-10 标题 :Process for the preparation of carbapenem antibiotics 发明人:CHRISTENSEN BURTON G; SHIH DAVID H 权利人:MERCK & CO INC 摘要:Disclosed is a process for the synthesis of carbapenem antibiotics I and their pharmaceutically acceptable salts and esters from 1: wherein: R7, R6, R1, R2 and R8 are selected from hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl, spirocycloalkyl, cycloalkylalkyl, alkylcycloalkyl, aryl, aralkyl, aralkenyl, aralkynyl, heteroalkyl, heteroaralkyl, heterocyclyl and heterocyclyalkyl.
专利号:US-9695208-B2 优先权日:2010-06-09 标 题:Sialic acid (A-(2-6))-D-aminopyranose derivatives, synthesis methods and uses thereof 发明人:YE XINSHAN; YANG FAN; ZHENG XIUJING 权利人:YE XINSHAN; YANG FAN; ZHENG XIUJING; UNIV BEIJING 摘要:N-acyl modified sialic acid (α-(2→6))-D-aminopyranose derivatives, their synthesis methods and uses are disclosed. Sialic acid (α-(2→6))-D-aminopyranose derivatives represented by formula 1 are synthesized by using D-aminogalactose (glucose) and sialic acid as raw materials, which are coupled with carrier proteins or polypeptides to obtain glycoprotein (glycopeptide) conjugates. Acetyl is replaced by derivative acyl in the structures of said compounds, therefore the compounds show good activity in antitumor vaccines.