CAS: 50-33-9; 4-Butyl-1,2-Diphenylpyrazolidine-3,5-Dione

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CAS号23111-33-3 4-butyl-4-(hydr... | CAS号1229645-19-5 (4-butyl-3,5-di... | CAS号1229521-07-6 4-butyl-4-((met... | CAS号1229645-20-8 ((4-butyl-3,5-d... | CAS号133-08-4 正丁基丙二酸二乙酯 | CAS号122-66-7 1,2-二苯肼 | CAS号109-65-9 正溴丁烷 | CAS号2652-77-9 1,2-二苯-3,5吡唑二酮 | CAS号22293-38-5 Acetic acid,1,2... | CAS号3583-64-0 布马地宗 | CAS号16860-42-7 2-carboxy-2-hyd... | CAS号1227476-15-4 1,2-diphenyldiazene | CAS号129-20-4 羟基保泰松 | CAS号23111-33-3 4-butyl-4-(hydr... | CAS号26598-82-3 4-Butyl-4-methy... | CAS号27258-01-1 4-Butyl-1,2-dip... | CAS号37598-92-8 3-(1-benzylinda... | CAS号26485-63-2 4-butyl-4-chlor... | CAS号76383-45-4 4-butyl-1,2-dip...

(4-Butyl-3,5-Dioxo-1,2-Diphenylpyrazolidin-4-yl)Methyl Dihydrogen Phosphate置于human Placental Alkaline Phosphatase,Sodium Hydroxide,Magnesium Chloride,Zinc(II) Chloride体系中,用 乙醇,水 作为反应溶剂,化学反应生成 保泰松
参考文献:β-二羰基碳酸的新型前药策略:C-磷酰氧基甲基(pom)和磷酰氧基甲基氧基甲基(pomom)前药衍生物的合成和理化特性评估.
标题:β-二羰基碳酸的新型前药策略:C-磷酰氧基甲基(pom)和磷酰氧基甲基氧基甲基(pomom)前药衍生物的合成和理化特性评估.
摘要:由β-二羰基碳酸药物在反应性α-碳处衍生化而得的c-磷酰氧基甲基(pom)和磷酰氧基甲基氧基甲基(pomom)前药代表着一种独特的方法,可改善其化学稳定性和水溶性.这项工作评估了苯基丁a和苯并二酮的前药的理化和体外酶促生物转化的可行性.苯丁a的pom和pomom前药衍生物具有高度水溶性(> == 250 Mg / Ml),化学性质稳定,预计保质期为4.5年(ph 3.5,25摄氏度)和1.1年(ph 6.0,25摄氏度)),分别.有趣的是,这两种前药衍生物都没有表现出许多磷酸单酯所特有的ph依赖性,尽管它们的表观热力学活化参数相似,但其水解机理与其他磷酸盐相似.这些前药经历了碱性磷酸酶催化的生物转化为各自的碳酸盐,Pomom衍生物显示出预期的更快速度.另外,与苯并菲的氧化不稳定性形成鲜明对比的是,其pom前药是稳定的.这些研究的结果再次证实了通过共价掺入pom或pomom蛋白质来暂时"
DOI:10.1002/jps.22021

专利信息

专利号:US-2024287520-A1
优先权日:2021-06-30
标题:Method for synthesis of linkage modified oligomeric compounds
发明人：RODRIGUEZ ANDREW A
权利人:IONIS PHARMACEUTICALS INC
摘要:The present disclosure provides methods of synthesizing modified oligonucletodies and oligomeric compounds (including oligomeric compounds that are antisense agents or portions thereof) comprising a modified oligonucleotide having at least one modified internucleoside linking group. In certain embodiments, the present disclosure provides stabilized formulations of certain sulfonyl azides for use in the synthesis of olignonucleotides comprising one or more sulfonyl phosphoramidate linkages. Some embodiments provide stabilized compositions of high energy reagents that may be used in the synthesis of modified oligonucleotides, allowing for safe process scale preparation thereof.

专利号:US-2004242897-A1
优先权日:2002-07-31
标题 :Universal support media for synthesis of oligomeric compounds
发明人：GUZAEV ANDREI P; MANOHARAN MUTHIAH
摘要:Compounds for the synthesis of oligomeric compounds, particularly oligonucleotides and oligonucleotide mimetics, are provided. In addition, methods for functionalizing a support medium with a first monomeric subunit and methods for the synthesis of oligomeric compounds utilizing the novel compounds bound to support media are provided.

专利号:US-2012177593-A1
优先权日:2009-07-20
标 题 :Synthesis of dendrimer conjugates
发明人：BAKER JR JAMES R; ZHANG YUEHUA; THOMAS THOMMEY P; DESAI ANKUR MAHESH
权利人:BAKER JR JAMES R; ZHANG YUEHUA; THOMAS THOMMEY P; DESAI ANKUR MAHESH; UNIV MICHIGAN
摘要:The present invention relates to novel methods of synthesis of therapeutic and diagnostic dendrimers. In particular, the present invention is directed to novel dendrimer conjugates, novel methods of synthesizing the same, compositions comprising the conjugates, as well as systems and methods utilizing the conjugates (e.g., in diagnostic and/or therapeutic settings (e.g., for the delivery of therapeutics, imaging, and/or targeting agents (e.g., in disease (e.g., cancer, inflammatory disease) diagnosis and/or therapy, pain therapy, etc.)). Accordingly, dendrimer conjugates of the present invention may further comprise at least two different components for targeting, imaging, sensing, and/or providing a therapeutic or diagnostic material and/or monitoring response to therapy. Furthermore, the novel synthesis methods of certain embodiments of the present invention provide significant advantages with regard to total reaction time and simplicity.

专利号:US-11725070-B2
优先权日:2018-05-09
标 题:Polymerization process for the synthesis of vinyl aromatic polymers with a controlled structure
发明人：GHELFI FRANCO; FERRANDO ANGELO; LONGO ALDO; BUFFAGNI MIRKO
权利人:VERSALIS SPA
摘要:The present invention relates to a polymerization process for the synthesis of vinyl aromatic polymers, in which the sequence of monomers in the chain and the linear, branched soluble, or crosslinked insoluble structure, with reactive or different polarity functions, are controlled. Said process comprises the step of polymerizing vinyl aromatic monomers by means of an Atom Transfer Radical Polymerization (ATRP) reaction with an Activator ReGenerated by Electron Transfer (ARGET), the reaction being carried out at a temperature comprised between 25° C. and 110° C. in an inert gas atmosphere in the presence of a complex catalyst containing a cupric halide and a multidentate amine ligand, feeding to the reaction an organic initiator having two geminal halogens, an alkali metal (bi)carbonate, a solvent pair of an aliphatic alcohol and an acetic ester of the same aliphatic alcohol and possibly ascorbic acid, provided that no initiator is used with three or more active halogens, or polyvinyl monomers or inimers.

专利号:WO-2004011474-A1
优先权日:2002-07-31
标题:Universal support media for synthesis of oligomeric compounds
发明人：GUZAEV ANDREI P; MANOHARAN MUTHIAH; RAVIKUMAR VASULINGA T; KUMAR RAJU K
权利人:ISIS PHARMACEUTICALS INC; GUZAEV ANDREI P; MANOHARAN MUTHIAH; RAVIKUMAR VASULINGA T; KUMAR RAJU K
摘要:Compounds for the synthesis of oligomeric compounds, particularly oligonucleotide and oligonucleotide mimetics, are provided. In addition, methods for functionalizing a support medium with a first monomeric subunit and methods for the synthesis of oligomeric compounds utilizing the novel compounds bound to support media are provided.

专利号:US-6653468-B1
优先权日:2002-07-31
标 题 :Universal support media for synthesis of oligomeric compounds
发明人：GUZAEV ANDREI P; MANOHARAN MUTHIAH
权利人:ISIS PHARMACEUTICALS INC
摘要:Compounds for the synthesis of oligomeric compounds, particularly oligonucleotides and oligonucleotide mimetics, are provided. In addition, methods for functionalizing a support medium with a first monomeric subunit and methods for the synthesis of oligomeric compounds utilizing the novel compounds bound to support media are provided.