CAS: 4775-80-8; S-Phenylmercapturic Acid

该化合物是一种属于甲卡普杜里酸类的化学化合物,是甲卡布蒂酸和苯基化合物的结合体,其特征是其结构,包括附属于甲卡底酸酸混合物的一个苯基组,通常通过苯性异硫氰酸与谷硫酮的结合而形成,是一种极地,可溶水化合物,允许其在尿液中排出,使它成为接触某些环境毒素,尤其是与芳香化合物有关的毒素的有用生物标志;由于苯基甲基丙酸在新陈代谢中所起的作用,经常在毒理学和环境健康方面进行研究;生物样本中含有该物质,可以表明接触特定化学品的情况,有助于风险评估和流行病学研究;此外,该物质可能表现出不同程度的生物活动,尽管其主要意义在于其在解毒过程中作为代谢性副产品的作用.

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上下游产品

N-acetylcystein S-(4-Bromophenyl)mercapturic acid (R)-2-acetamido-3-((4-bromophenyl)thio)propanoic acid S-phenyl-L-cysteine2-(S)-amino-3-phenylsulfanylpropionic acid acetic acid (R)-2-Acetylamino-3-benzenesulfinyl-N-benzyl-propionamide

合成工艺路线路线简述

    📜N-乙酰-L-半胱氨酸置于buffered Hcl-Salt Benzenediazonium-Chloride-Solution体系中,化学反应生成 S-苯汞基酸
    参考文献:Zbarsky; Young,Journal Of Biological Chemistry,1943,Vol. 151,P. 211,212
    标题:Zbarsky; Young,Journal Of Biological Chemistry,1943,Vol. 151,P. 211,212

    海关参考信息

    专利信息


    专利号:US-2024355410-A1
    优先权日:2021-10-27
    标题:Method and systems for a machine-assisted discovery of chondroitinase abc complexes towards sustained neural regeneration
    发明人:GORMLEY ADAM J; TAMASI MATTHEW; KOSURI SHASHANK; WEBB MICHAEL ANTHONY; BORCA CARLOS HERNAN; PATEL ROSHAN ANIT
    权利人:UNIV RUTGERS; UNIV PRINCETON
    摘要:Disclosed are systems and methods that provide a framework for machine-assisted discovery of Chondroitinase ABC (ChABC) complexes towards sustained neural regeneration. In some embodiments, the framework may leverage a determination of a diverse set of tailor-made random copolymers that complex and stabilize ChABC at physiological temperature. The copolymer designs, which are based on chain length and/or composition of the copolymers, may be identified using an active machine learning paradigm, which involves, but is not limited to, copolymer synthesis, testing for ChABC thermostability upon copolymer complexation, Gaussian Process Regression modeling and Bayesian optimization. Copolymers are synthesized by automated PET-RAFT, and thermostability of ChABC may be assessed by retained enzyme activity (REA) after a predefined interval of hours at 37° C.

    专利号:WO-2022270853-A1
    优先权日:2021-06-21
    标 题:Clcf1 protein and use thereof
    发明人:KWON KI-SUN; YANG YONG RYOUL; PARK JI HOON; CHOI SO-YOUNG; KANG JAE SOOK; KIM MINJU
    权利人:KOREA RES INST BIOSCIENCE & BIOTECHNOLOGY; OSONG MEDICAL INNOVATION FOUND
    摘要:The present invention relates to a composition for preventing or treating a muscular disease having at least one symptom selected from muscle damage, muscular dysfunction, muscle weakness, muscle atrophy, and muscle mass decline, a composition for promoting differentiation of myoblasts, and a composition for strengthening muscle strength or increasing muscle mass, each comprising CLCF1 protein or a variant thereof as an active ingredient. In one embodiment of the present invention, the CLCF1 protein or a variant thereof has effects of increasing muscle mass, promoting protein synthesis in myocytes, improving muscle functions, and increasing resistance to muscle fatigue, so that the composition according to the present invention can be advantageously used for promoting differentiation of myoblasts and preventing, alleviating, or treating diseases related to muscle loss and/or muscle weakness.

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    ✅ COA系统入驻 | 共享模式

    合成参考文献


    参考文献:10.1080/08958370600747945
    摘要:Scherer G, Urban M, Engl J, Hagedorn HW, Riedel K. Influence of smoking charcoal filter tipped cigarettes on various biomarkers of exposure. Inhal Toxicol. 2006 Sep;18(10):821–9. doi: 10.1080/08958370600747945.
    参考文献:10.1002/bmc.653
    摘要:Li Y, Li AC, Shi H, Junga H, Jiang X, Naidong W, Lauterbach JH. Determination of S-phenylmercapturic acid in human urine using an automated sample extraction and fast liquid chromatography-tandem mass spectrometric method. Biomed Chromatogr. 2006 Jun;20(6-7):597–604. doi: 10.1002/bmc.653.
    参考文献:10.1016/j.cbi.2008.02.004
    摘要:Navasumrit P, Arayasiri M, Hiang OM, Leechawengwongs M, Promvijit J, Choonvisase S, Chantchaemsai S, Nakngam N, Mahidol C, Ruchirawat M. Potential health effects of exposure to carcinogenic compounds in incense smoke in temple workers. Chem Biol Interact. 2008 May 09;173(1):19–31. doi: 10.1016/j.cbi.2008.02.004.
    参考文献:10.3390/ijerph16122240
    摘要:Costa-Amaral IC, Carvalho LVB, Santos MVC, Valente D, Pereira AC, Figueiredo VO, Souza JM, Castro VS, Trancoso MF, Fonseca ASA, Milagres VG, Mendes MPR, Paiva MJN, André LC, Borges RM, Menezes MAC, Alves SR, Gonçalves ES, Sisenando HA, Perini JA, Oliveira MS, Moura-Correa MJ, Teixeira LR, Collins AR, Mattos RCOC, Sarcinelli PN, Larentis AL. Environmental Assessment and Evaluation of Oxidative Stress and Genotoxicity Biomarkers Related to Chronic Occupational Exposure to Benzene. Int J Environ Res Public Health. 2019 Jun 25;16(12).
    参考文献:10.1007/bf00386572
    摘要:Popp W, Rauscher D, Miiller G, Angerer J, Norpoth K. Concentrations of benzene in blood and S-phenylmercapturic and t,t-muconic acid in urine in car mechanics. International Archives of Occupational and Environmental Health. 1994 May;66(1):1–6. doi: 10.1007/bf00386572.
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