专利号:US-2024355410-A1 优先权日:2021-10-27 标题:Method and systems for a machine-assisted discovery of chondroitinase abc complexes towards sustained neural regeneration 发明人:GORMLEY ADAM J; TAMASI MATTHEW; KOSURI SHASHANK; WEBB MICHAEL ANTHONY; BORCA CARLOS HERNAN; PATEL ROSHAN ANIT 权利人:UNIV RUTGERS; UNIV PRINCETON 摘要:Disclosed are systems and methods that provide a framework for machine-assisted discovery of Chondroitinase ABC (ChABC) complexes towards sustained neural regeneration. In some embodiments, the framework may leverage a determination of a diverse set of tailor-made random copolymers that complex and stabilize ChABC at physiological temperature. The copolymer designs, which are based on chain length and/or composition of the copolymers, may be identified using an active machine learning paradigm, which involves, but is not limited to, copolymer synthesis, testing for ChABC thermostability upon copolymer complexation, Gaussian Process Regression modeling and Bayesian optimization. Copolymers are synthesized by automated PET-RAFT, and thermostability of ChABC may be assessed by retained enzyme activity (REA) after a predefined interval of hours at 37° C.
专利号:WO-2022270853-A1 优先权日:2021-06-21 标 题:Clcf1 protein and use thereof 发明人:KWON KI-SUN; YANG YONG RYOUL; PARK JI HOON; CHOI SO-YOUNG; KANG JAE SOOK; KIM MINJU 权利人:KOREA RES INST BIOSCIENCE & BIOTECHNOLOGY; OSONG MEDICAL INNOVATION FOUND 摘要:The present invention relates to a composition for preventing or treating a muscular disease having at least one symptom selected from muscle damage, muscular dysfunction, muscle weakness, muscle atrophy, and muscle mass decline, a composition for promoting differentiation of myoblasts, and a composition for strengthening muscle strength or increasing muscle mass, each comprising CLCF1 protein or a variant thereof as an active ingredient. In one embodiment of the present invention, the CLCF1 protein or a variant thereof has effects of increasing muscle mass, promoting protein synthesis in myocytes, improving muscle functions, and increasing resistance to muscle fatigue, so that the composition according to the present invention can be advantageously used for promoting differentiation of myoblasts and preventing, alleviating, or treating diseases related to muscle loss and/or muscle weakness.
参考文献:10.1080/08958370600747945 摘要:Scherer G, Urban M, Engl J, Hagedorn HW, Riedel K. Influence of smoking charcoal filter tipped cigarettes on various biomarkers of exposure. Inhal Toxicol. 2006 Sep;18(10):821–9. doi: 10.1080/08958370600747945. 参考文献:10.1002/bmc.653 摘要:Li Y, Li AC, Shi H, Junga H, Jiang X, Naidong W, Lauterbach JH. Determination of S-phenylmercapturic acid in human urine using an automated sample extraction and fast liquid chromatography-tandem mass spectrometric method. Biomed Chromatogr. 2006 Jun;20(6-7):597–604. doi: 10.1002/bmc.653. 参考文献:10.1016/j.cbi.2008.02.004 摘要:Navasumrit P, Arayasiri M, Hiang OM, Leechawengwongs M, Promvijit J, Choonvisase S, Chantchaemsai S, Nakngam N, Mahidol C, Ruchirawat M. Potential health effects of exposure to carcinogenic compounds in incense smoke in temple workers. Chem Biol Interact. 2008 May 09;173(1):19–31. doi: 10.1016/j.cbi.2008.02.004. 参考文献:10.3390/ijerph16122240 摘要:Costa-Amaral IC, Carvalho LVB, Santos MVC, Valente D, Pereira AC, Figueiredo VO, Souza JM, Castro VS, Trancoso MF, Fonseca ASA, Milagres VG, Mendes MPR, Paiva MJN, André LC, Borges RM, Menezes MAC, Alves SR, Gonçalves ES, Sisenando HA, Perini JA, Oliveira MS, Moura-Correa MJ, Teixeira LR, Collins AR, Mattos RCOC, Sarcinelli PN, Larentis AL. Environmental Assessment and Evaluation of Oxidative Stress and Genotoxicity Biomarkers Related to Chronic Occupational Exposure to Benzene. Int J Environ Res Public Health. 2019 Jun 25;16(12). 参考文献:10.1007/bf00386572 摘要:Popp W, Rauscher D, Miiller G, Angerer J, Norpoth K. Concentrations of benzene in blood and S-phenylmercapturic and t,t-muconic acid in urine in car mechanics. International Archives of Occupational and Environmental Health. 1994 May;66(1):1–6. doi: 10.1007/bf00386572.