CAS: 447-43-8; 1-(4-Fluorophenyl)-2,2-Dihydroxyethan-1-One

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CAS号403-42-9 对氟苯乙酮 | CAS号403-32-7 4-氟代苯甲酰甲醛 | CAS号327623-37-0 (2S,3r)-2-((s)-... | CAS号172822-29-6 ENT-阿瑞匹坦

📜4-氟苯乙酮置于氢溴酸体系中,用 水,二甲基亚砜,甲苯 作为反应溶剂,以73%的收率获得产物4-氟苯甲酰甲醛水合物
参考文献:Chemical Synthesis Of 1,4-Oxazin-2-Ones
标题:Chemical Synthesis Of 1,4-Oxazin-2-Ones
摘要:本发明涉及一种制备式(I)化合物的方法:##str1## 其中r.Sup.1是c.Sub.1-6烷基或芳基c.Sub.1-4烷基基团;r.Sup.2是氢原子,卤素原子或从c.Sub.1-6烷基,Cf.Sub.3或c.Sub.1-6烷氧基被c.Sub.1-4烷氧基取代的基团中选择的基团;该方法包括在酸的存在下将式(II)的无水或水合的丙二醛与式(Iii)的化合物反应.

专利信息

专利号:US-6395898-B1
优先权日:2000-06-09
标 题:Trans-glycosidation process for the synthesis of (2R, 2-alpha-R, 3a)-2-[1-(3,5-bis(trifluoromethyl)phenyl)ethoxy]-3-(4-fluorophenyl)-1,4-oxazine
发明人：MCNAMARA JAMES M; ZHAO MATTHEW M
权利人:MERCK & CO INC
摘要:The present invention is concerned with novel processes for the preparation of (2R, 2-alpha-R, 3a)-2-[1-[3,5-bis(trifluoromethyl)phenyl]ethoxy-3-(4-fluorophenyl)-1,4-oxazine. This compound is useful as an intermediate in the synthesis of compounds which possess pharmacological activity.

专利号:US-6130331-A
优先权日:1998-09-11
标题 :Chemical synthesis of a chiral 1,4-oxazin-2-one
发明人：ASHWOOD MICHAEL STEWART; COTTRELL IAN FRANK; BISHOPS BRIAN CHRISTOPHER; EDWARDS JOHN SIMON
权利人:MERCK SHARP & DOHME
摘要:The present invention relates to a process for the preparation of substantially pure N-((S)-(-)-α-methylbenzyl)-3-(S)-(4-fluorophenyl)-1,4-oxazin-2-one hydrochloride, which comprises selectively crystallising the (S,S)-diastereomer as the hydrochloride salt from a mixture of the (S,R)- and (S,S)-diastereomers in an organic solvent, and collecting the resultant crystalline product.

专利号:US-6046325-A
优先权日:1998-09-11
标 题:Chemical synthesis of 1,4-oxazin-2-ones
发明人：ASHWOOD MICHAEL STEWART; BISHOP BRIAN CHRISTOPHER; COTTRELL IAN FRANK
权利人:MERCK SHARP & DOHME
摘要:The present invention relates to a process for the preparation of a compound of formula (I): ##STR1## wherein R 1 is a C 1-6 alkyl or arylC 1-4 alkyl group; and R 2 is a hydrogen atom, a halogen atom, or a group selected from C 1-6 alkyl, CF 3 or C 1-6 alkoxy substituted by C 1-4 alkoxy; which comprises reacting an anhydrous or hydrated glyoxal of formula (II) with a compound of formula (III): ##STR2## in the presence of an acid.

专利号:GB-2341387-A
优先权日:1998-09-11
标题 :Synthesis of a chiral 1,4-oxazin-2-one derivative

专利号:US-2002022725-A1
优先权日:2000-06-09
标 题 :Trans-glycosidation process for the synthesis of (2R, 2-alpha-R, 3a) -2-(1- (3,5-bis(trifluoromethyl) phenyl) ethoxy ) -3- (4-fluorophenyl) -1, 4-oxazine

专利号:WO-0196319-A1
优先权日:2000-06-09
标题 :Trans-glycosidation process for the synthesis of (2r, 2-alpha-r, 3a)-2-[1-(3,5-bis(trifluoromethyl)phenyl)ethoxy]-3-(4-fluorophenyl)-1,4-oxazine