CAS: 2899-37-8; (S)-2-Amino-4-(Methylthio)Butan-1-Ol

相似化合物

51372-93-1 2491-18-1 348-67-4

上下游产品

CAS号63-68-3 L-蛋氨酸 | CAS号10332-17-9 L-Methionine, m... | CAS号2899-36-7 L-蛋氨酸乙酯盐酸盐 | CAS号51372-93-1 B°C-氨醇

L-蛋氨酸 反应生成L-蛋氨醇
参考文献:使用 α,α-二氟烷基胺轻松合成恶唑啉,噻唑啉和咪唑啉
标题:使用 α,α-二氟烷基胺轻松合成恶唑啉,噻唑啉和咪唑啉
摘要:β-氨基醇,β-氨基硫醇和β-二胺可通过在温和条件下与α,α-二氟烷基胺反应分别转化为相应的恶唑啉,噻唑啉和咪唑啉衍生物.该反应适用于光学活性杂环化合物的合成.
Doi:10.1055/s-2007-966038

专利信息

专利号:US-10040752-B2
优先权日:2015-08-24
标 题 :Synthesis of levomethadone hydrochloride or dextromethadone hydrochloride and methods for use thereof
发明人：MKRTCHYAN GNEL; YAO QINGWEI
权利人:CODY LABORATORIES INC
摘要:Highly efficient methods for synthesis of levomethadone hydrochloride or dextromethadone hydrochloride are provided starting from D-alanine, or L-alanine, respectively, with retention of configuration. Methods for treating a subject are provided comprising administering a composition comprising an effective amount of levomethadone hydrochloride having not more than 10 ppm dextromethadone.

专利号:US-4254023-A
优先权日:1979-10-16
标题:Synthesis of peptide alcohols by the solid phase method
发明人：STEWART JOHN M; MORRIS DAN H
权利人:PENNWALT CORP
摘要:A method for preparing novel peptide alcohols exemplified by the reduction of enkephalins and particularly the met-enkephalin to produce pentapeptides and tetrapeptides of the following formula n n H-Tyr-DAla-Gly-Phe-Methioninol (1) n n n H-Tyr-DAla-Phe-Methioninol (2) n n Additional alcohols having a carbon or C-number exceeding or less than 4 or 5 may also be prepared. These compounds are produced by solid phase peptide synthesis developed by R. B. Merrifield in Advances in Enzymology, 32:221 (1969 ) in which the terminal carboxyl group is reduced to the alcohol under the influence of lithium borohydride.

专利号:US-2005192265-A1
优先权日:2003-03-20
标 题:Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting beta-amyloid peptide release and/or its synthesis by use of such compounds
发明人：THOMPSON RICHARD C; WILKIE STEPHEN; STACK DOUGLAS R; VANMETER ELDON E; SHI QING; BRITTON THOMAS C; AUDIA JAMES E; REEL JON K; MABRY THOMAS E; DRESSMAN BRUCE A; CWI CYNTHIA L; HENRY STEVEN S; MCDANIEL STACEY L; STUCKY RUSSELL D; PORTER WARREN J
摘要:Disclosed are compounds which inhibit β-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions that include a compound which inhibits β-amyloid peptide release and/or its synthesis as well as methods for treating Alzheimer's disease both prophylactically and therapeutically with such pharmaceutical compositions.

专利号:US-6906056-B2
优先权日:1998-06-22
标 题:Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds
发明人：THOMPSON RICHARD C; WILKIE STEPHEN; STACK DOUGLAS R; VANMETER ELDON E; SHI QING; BRITTON THOMAS C; AUDIA JAMES E; REEL JON K; MABRY THOMAS E; DRESSMAN BRUCE A; CWI CYNTHIA L; HENRY STEVEN S; MCDANIEL STACEY L; STUCKY RUSSELL D; PORTER WARREN J
权利人:LILLY CO ELI
摘要:Disclosed are compounds which inhibit β-amyloid peptide release and/or its synthesis, and, accordingly, have utility in treating Alzheimer's disease. Also disclosed are pharmaceutical compositions that include a compound which inhibits β-amyloid peptide release and/or its synthesis as well as methods for treating Alzheimer's disease both prophylactically and therapeutically with such pharmaceutical compositions.

专利号:US-2021171437-A1
优先权日:2017-07-17
标题 :Peptide nucleic acid (pna) monomers with an orthogonally protected ester moiety and novel intermediates and methods related thereto
发明人：COULL JAMES M; GILDEA BRIAN D
权利人:VERA THERAPEUTICS INC
摘要:The present disclosure pertains to peptide nucleic acid (PNA) monomers and oligomers, as well as methods and compositions useful for the preparation of PNA monomer precursors (e.g. PNA Monomer Esters, Backbone Esters and Backbone Ester Acid Salts, as described below) that can be used to prepare PNA monomers wherein said PNA monomers can be used to prepare said PNA oligomers. In some embodiments, the disclosure features sulfonic acid salts of Backbone Ester compounds, which sulfonic acid salts generally tend to be crystalline and can be obtained in reasonably good yield, often without requiring any chromatographic purification of the reaction product of the Backbone Ester synthesis reaction. This disclosure also pertains to novel methods for the synthesis of said Backbone Ester compounds and novel methods for the formation of the related sulfonic acid salts. Exemplary ester groups include, but are not limited to, 2,2,2-trichloroethy-(TCE), 2,2,2-tribromoethyl-(TBE), 2-iodoethyl-groups (2-IE) and 2-bromoethyl-(2-BrE) as the ester group. These particular ester groups can be removed under conditions where both Boc and Fmoc protected amine groups are stable.

专利号:US-2019002394-A1
优先权日:2015-08-24
标 题 :Synthesis of levomethadone hydrochloride or dextromethadone hydrochloride and methods for use thereof