📜2-(氯甲基)-1-甲氧基-4-硝基苯 反应生成2-甲氧基-5-硝基苯甲醛 参考文献:Quelet,R.; Coudanne,H.,Bulletin De La Societe Chimique De France,1963,P. 2445-2449 标题:Quelet,R.; Coudanne,H.,Bulletin De La Societe Chimique De France,1963,P. 2445-2449
专利号:EP-0675886-B1 优先权日:1992-12-10 标题:Aminomethylene substituted non-aromatic heterocycles and use as substance p antagonists 发明人:HOWARD HARRY R; O'NEILL BRIAN T 权利人:PFIZER 摘要: The present invention relates to novel aminomethylene substituted non-aromatic heterocycles and, specifically, to compounds of formula (Ib) wherein W, R<2>, R<3>, X', Y' and Z' are as defined in the specification, and to intermediates used in the synthesis of such compounds. The novel compounds of formula (Ib) are useful in the treatment of inflammatory and central nervous system disorders, as well as other disorders.
专利号:US-6369074-B1 优先权日:1992-12-10 标 题:Aminomethylene substituted non-aromatic heterocycles and use as substance P antagonists 发明人:HOWARD HARRY R; O'NEILL BRIAN T 权利人:PFIZER 摘要:The present invention relates to novel aminomethylene substituted non-aromatic heterocycles and, specifically, to compounds of the formula n wherein W, R 1 , R 2 , R 3 , A, X′, Y′ and Z′ are as defined in the specification, and to intermediates used in the synthesis of such compounds. The novel compounds of formulae Ia and Ib are useful in the treatment of inflammatory and central nervous system disorders, as well as other disorders.