6-己内酯置于氯化亚砜,硫酸,氢溴酸体系中,化学反应 11.0H,反应生成6-溴己酰氯 参考文献:"Mercaptan-Tail" Porphyrins: Synthetic Analogs For The Active Site Of Cytochrome P-450 标题:"Mercaptan-Tail" Porphyrins: Synthetic Analogs For The Active Site Of Cytochrome P-450 摘要: Doi:10.1021/ja00369A041
专利号:US-2024287269-A1 优先权日:2021-11-02 标 题 :Synthesis of poly(phenylene) compound intergrated with functionalized fluorene portion for ion exchange ionomer and ion exchange ionomer 发明人:ZHANG QIUYING; BAHAR BAMDAD; CHEN MENGJIE 权利人:USA FORTESCUE IP INC 摘要:An ion exchange polymer has an ionomer structure containing poly(phenylene) compound integrated with functionalized poly(fluorene). The ion conducting co-polymer includes a poly(fluorene) compound and a poly(phenylene) compound covalently bonded together. The poly(fluorene) compound has a 9H-fluorene structure that is a polycyclic aromatic hydrocarbon having a center ring with five carbon atoms, and a benzene ring on each of opposing sides of said center ring. The poly(phenylene) compound is covalently bonded to each of the pair of benzene rings of the poly(fluorene) compound. A pair of sidechains extends from the center ring of the poly(fluorene) compound to a respective terminal group. The terminal groups are configured on sidechains of the poly(fluorene) compound and can be converted into functional groups such as quaternary ammonium or n-methyl piperidine functional groups. The ion exchange polymer may include a porous scaffold support.
专利号:US-2014046086-A1 优先权日:2012-08-10 标题:Process for the preparation of tafluprost and intermediates thereof 发明人:WEN WEN-HSIEN 权利人:SCINOPHARM CHANGSHU PHARMACEUTICALS LTD 摘要:The present invention provides efficient, economical and environmental friendly methods for synthesis of prostaglandin analogs including tafluprost and intermediates thereof. The invention involves a selective oxidation using in situ boronate ester protection and a unique crystallization method to remove the undesired isomers of fluorinated intermediates.
专利号:US-2010210474-A1 优先权日:2007-09-17 标 题:Heterocyclic scaffolds useful for preparation of combinatorial libraries, libraries and methods for preparation thereof 发明人:GELLERMAN GARY 权利人:GELLERMAN GARY 摘要:Disclosed are heterocyclic scaffolds useful, for example, for solid-phase organic synthesis of combinatorial libraries and methods for the preparation thereof. Also disclosed are libraries, including combinatorial libraries, and methods for preparation thereof. Exemplified are the following scaffolds (I):
专利号:US-8729257-B2 优先权日:2009-07-17 标题 :Hybrid lipid compounds based on pentaerythritol, intermediates, preparation methods and use thereof 发明人:DAI ZHIFEI; LIANG XIAOLONG; YUE XIULI 权利人:DAI ZHIFEI; LIANG XIAOLONG; YUE XIULI; HARBIN INST OF TECHNOLOGY 摘要:This invention relates to a novel class of hybrid lipid compound based on pentaerythritol, their intermediates, preparation methods and uses thereof. Different kinds of functional groups such as alkyl chain, siloxane group, azobenzene, porphyrins, cholesterol, benzene ring and carboxyl were introduced into the four hydroxyl groups of pentaerythritol through chemical reaction to obtain the final hybrid lipid compounds based on pentaerythritol. Cerasomes prepared from such lipids have uniform size, silicate network surface, good stability and biocompatibility, and the leakage of drugs is not easy. The present liposome can be used as functional materials such as drugs or drug carriers, or used for optical storage and molecular devices, simulation, design and synthesis of artificial systems, nano-composite membrane materials and the removal of organic pollutants, etc., in addition, the preparation method of the present invention is simple, and it is easy for industrial production.
专利号:RU-2418798-C2 优先权日:2005-08-31 标 题 :Synthesis methods and intermediate compounds during synthesis of stereoisomeric compounds, suitable for treating gastrointestinal disorders and central nervous system disorders
专利号:US-8137582-B2 优先权日:2007-08-15 标题 :Alkaloid monomers, liquid crystal compositions and polymer networks derived therefrom 发明人:GOLDFINGER MARC B; QI KAI 权利人:GOLDFINGER MARC B; QI KAI; DU PONT 摘要:Disclosed is the chemical synthesis of chiral alkaloid monomers, liquid crystal compositions comprising the chiral alkaloid monomers, and polymerization of the liquid crystal compositions to provide polymer networks with useful cholesteric optical properties and stability.