CAS: 22809-37-6; 6-Bromohexanoylchloride

该化合物是一种多功能烷基卤化烷基氯化物,广泛用于有机合成和制药中间体,其主要优点包括反应性丙烯基氯组,能够产生高效的相互碰撞反应,以及最终的溴原子,它通过核循环替代或交叉反应促进进一步功能化.该化合物对于准备异性循环,聚合物和生物活性分子特别宝贵.在受控条件下和与一系列溶剂的兼容性增强了其在多步合成中的效用.建议由于惰性大气的湿度敏感度和对核分裂性的潜在反应,在惰性大气中进行适当处理.

结构式图片

相似化合物

4509-90-4 19347-73-0 1575-61-7

欧盟法规

ECHA物质C&L通报REACH预注册

上下游产品

6-bromohexanoic acid 6-Bromhexansaeure-trimethylsilylester hexahydro-2H-oxepin-2-one 6-bromo-1-hexanenitrile α-(6-bromhexanoyl)-S-benzyl-L-cysteinamidN-Dodecyl-Nα-(6-bromhexanoyl)-S-benzyl-L-cysteinamid 1-bromo-5-is°Cyanatopentane 6-bromo-1-phenyl-1-hexanone N-(6-brom°Caproyl)-N-(2-methoxybenzyl)amine

合成工艺路线路线简述

  • 合成目标产物 6-Bromohexanoyl Chloride 主要起始原料 ε-Caprolactone
  • (文献来源)合成步骤主要原料 ε-Caprolactone
6-己内酯置于氯化亚砜,硫酸,氢溴酸体系中,化学反应 11.0H,反应生成6-溴己酰氯
参考文献:"Mercaptan-Tail" Porphyrins: Synthetic Analogs For The Active Site Of Cytochrome P-450
标题:"Mercaptan-Tail" Porphyrins: Synthetic Analogs For The Active Site Of Cytochrome P-450
摘要:
Doi:10.1021/ja00369A041

海关参考信息

专利信息


专利号:US-2024287269-A1
优先权日:2021-11-02
标 题 :Synthesis of poly(phenylene) compound intergrated with functionalized fluorene portion for ion exchange ionomer and ion exchange ionomer
发明人:ZHANG QIUYING; BAHAR BAMDAD; CHEN MENGJIE
权利人:USA FORTESCUE IP INC
摘要:An ion exchange polymer has an ionomer structure containing poly(phenylene) compound integrated with functionalized poly(fluorene). The ion conducting co-polymer includes a poly(fluorene) compound and a poly(phenylene) compound covalently bonded together. The poly(fluorene) compound has a 9H-fluorene structure that is a polycyclic aromatic hydrocarbon having a center ring with five carbon atoms, and a benzene ring on each of opposing sides of said center ring. The poly(phenylene) compound is covalently bonded to each of the pair of benzene rings of the poly(fluorene) compound. A pair of sidechains extends from the center ring of the poly(fluorene) compound to a respective terminal group. The terminal groups are configured on sidechains of the poly(fluorene) compound and can be converted into functional groups such as quaternary ammonium or n-methyl piperidine functional groups. The ion exchange polymer may include a porous scaffold support.

专利号:US-2014046086-A1
优先权日:2012-08-10
标题:Process for the preparation of tafluprost and intermediates thereof
发明人:WEN WEN-HSIEN
权利人:SCINOPHARM CHANGSHU PHARMACEUTICALS LTD
摘要:The present invention provides efficient, economical and environmental friendly methods for synthesis of prostaglandin analogs including tafluprost and intermediates thereof. The invention involves a selective oxidation using in situ boronate ester protection and a unique crystallization method to remove the undesired isomers of fluorinated intermediates.

专利号:US-2010210474-A1
优先权日:2007-09-17
标 题:Heterocyclic scaffolds useful for preparation of combinatorial libraries, libraries and methods for preparation thereof
发明人:GELLERMAN GARY
权利人:GELLERMAN GARY
摘要:Disclosed are heterocyclic scaffolds useful, for example, for solid-phase organic synthesis of combinatorial libraries and methods for the preparation thereof. Also disclosed are libraries, including combinatorial libraries, and methods for preparation thereof. Exemplified are the following scaffolds (I):

专利号:US-8729257-B2
优先权日:2009-07-17
标题 :Hybrid lipid compounds based on pentaerythritol, intermediates, preparation methods and use thereof
发明人:DAI ZHIFEI; LIANG XIAOLONG; YUE XIULI
权利人:DAI ZHIFEI; LIANG XIAOLONG; YUE XIULI; HARBIN INST OF TECHNOLOGY
摘要:This invention relates to a novel class of hybrid lipid compound based on pentaerythritol, their intermediates, preparation methods and uses thereof. Different kinds of functional groups such as alkyl chain, siloxane group, azobenzene, porphyrins, cholesterol, benzene ring and carboxyl were introduced into the four hydroxyl groups of pentaerythritol through chemical reaction to obtain the final hybrid lipid compounds based on pentaerythritol. Cerasomes prepared from such lipids have uniform size, silicate network surface, good stability and biocompatibility, and the leakage of drugs is not easy. The present liposome can be used as functional materials such as drugs or drug carriers, or used for optical storage and molecular devices, simulation, design and synthesis of artificial systems, nano-composite membrane materials and the removal of organic pollutants, etc., in addition, the preparation method of the present invention is simple, and it is easy for industrial production.

专利号:RU-2418798-C2
优先权日:2005-08-31
标 题 :Synthesis methods and intermediate compounds during synthesis of stereoisomeric compounds, suitable for treating gastrointestinal disorders and central nervous system disorders

专利号:US-8137582-B2
优先权日:2007-08-15
标题 :Alkaloid monomers, liquid crystal compositions and polymer networks derived therefrom
发明人:GOLDFINGER MARC B; QI KAI
权利人:GOLDFINGER MARC B; QI KAI; DU PONT
摘要:Disclosed is the chemical synthesis of chiral alkaloid monomers, liquid crystal compositions comprising the chiral alkaloid monomers, and polymerization of the liquid crystal compositions to provide polymer networks with useful cholesteric optical properties and stability.
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合成参考文献


摘要:Kleemann, A.; Engel, J.; Kutscher, B.; Reichert, D., Pharmaceutical Substances[Online], Thieme: Stuttgart, (2014).
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