CAS: 204777-78-6; Fmoc-Lys(Ivdde)-Oh

相似化合物

862847-44-7 1173996-67-2 1446752-60-8

上下游产品

Fm°C-Lys-OH 2-(1-hydroxy-3-methylbutylidene)-5,5-dimethylcyclohexane-1,3-dione 3-methylbutyric acid dimedone

异戊酸 在 4-二甲氨基吡啶,N,N'-二环己基碳二亚胺,三氟乙酸体系中,用 乙醇作为反应溶剂,反应 60.0H,获得 FmOC-Lys(Ivdde)-Oh
参考文献:对用于固相肽合成的dde胺保护基新变体的评估
标题:对用于固相肽合成的dde胺保护基新变体的评估
摘要:已经开发了一系列在环外烯烃位置取代的dde的新变体,并评估了它们在固相肽合成中的应用.新的衍生物对dmf中的20%哌啶具有完全的抗性,并为n->N'-分子内迁移提供了相当大的屏障.
Doi:10.1016/S0040-4039(97)10828-0

专利信息

专利号:US-2024018099-A1
优先权日:2020-11-19
标题 :Synthesis of prostate specific membrane antigen (psma) ligands
发明人：ANDREAE FRITZ
权利人:NOVARTIS AG
摘要:The present disclosure relates to the synthesis of prostate specific membrane antigen (PSMA) ligands that are useful in the treatment of diseases like cancer. In particular, the disclosure relates to a method for synthesizing PSMA ligands having a glutamate-urea-lysine (GUL) moiety and a chelating agent that can comprise a radiometal.

专利号:US-2025231184-A1
优先权日:2022-10-12
标题:Nitrilotriacetic acid linkers, solid phase synthesis of nitrilotriacetic acid linkers and applications thereof
发明人：JAMALI HOJJAT S
权利人:NICOYA LIFESCIENCES INC
摘要:Described are devices, compounds and methods for detecting an analyte in a sample. More particularly this disclosure provides SPR and LSPR sensors modified by NTA linkers for binding a ligand and/or analyte. The NTA linkers of the disclosure typically include a head (or “anchoring siteâ€?) for coupling to a surface of the SPR or LSPR sensor, a spacer, and one or more attachment sites on a distal end or ends of the spacer which couple to a ligand. The head may include a thiol for coupling the linker to a surface of the SPR or LSPR sensor. The spacer may be a carbon chain. PAG or PEG chain, or matrix material. The one or more attachment sites may be a nitrilotriacetic acid (NTA) moiety capable of chelating a transition metal ion and binding the ligand.

专利号:WO-2023105497-A1
优先权日:2021-12-10
标题:Synthesis of glp-1 analogues
发明人：GODHA ATUL KASTURCHAND; NARAYANASWAMY SATHYA VANGANUR; BHAGYARAJ ARETI VENKATA; BAVADEKAR ASLAM JAHANGIR; LAKSHMANAPPA RUDRESH; NAGOOR SHEIKSYEDALI; MURUGAN RANJITHKUMAR; GADAKH AMOL VASANTRAO; SAMBASIVAM GANESH
权利人:ANTHEM BIOSCIENCES PVT LTD
摘要:The present invention provides a method of preparation of GLP-1 peptides by using different peptide fragments having amino acid sequences SEQ ID NO:1 (Fragment IG), SEQ ID NO:2 (Fragment SG), Fragment BG, SEQ ID NO:3, and SEQ ID NO:4 5 and combinations thereof. The method of preparation is environmentally benign, simple, straightforward, and efficient and provides the end product in high yield and purity. The purification method of the peptides is also described.

专利号:US-2024116978-A1
优先权日:2022-10-10
标 题:Method of preparing estradiol derivatives by solid-phase synthesis
发明人：OKARVI SUBHANI M; AL-JAMMAZ IBRAHIM
权利人:KING FAISAL SPECIALIST HOSPITAL & RES CENTRE
摘要:The present invention relates to a method of preparing estradiol derivatives and/or estrone derivatives, which are suitable for radiolabeling. The present invention further relates to the estradiol derivatives and/or estrone derivatives, preferably obtained by the method of the present invention, as well as to the use of the estradiol derivatives and/or estrone derivatives for radiolabeling with diagnostic and/or therapeutic radionuclides. The present invention further relates to a method of imaging and/or diagnosis of breast cancer as well as to a method of treatment of breast cancer.

专利号:US-2024010623-A1
优先权日:2020-11-19
标 题:Synthesis of prostate specific membrane antigen (psma) ligands

专利号:US-2024025866-A1
优先权日:2020-11-19
标 题:Synthesis of prostate specific membrane antigen (psma) ligands