CAS: 193533-92-5; 2,3,4-Trifluorotoluene

该化合物是一种含分子式C7H5F3的氟芳烃化合物,其特点是,在甲状腺环的2,3和4个位置上存在三个氟原子,增强了其电子提取特性和化学稳定性,该化合物通常用作制药和农用化学合成的中间体,其三氟甲基替代芳香结构有助于改进交叉反应的再活性和选择性,其高纯度和定义明确的再生化学使它成为先进的有机合成的宝贵建筑块.此外,其低沸点和普通有机溶剂中的溶解性促进了实验室和工业应用的高效处理.

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CAS号3862-73-5 2,3,4-三氟苯胺 | CAS号77-78-1 硫酸二甲酯 | CAS号176317-02-5 1-溴-2,3,4-三氟苯 | CAS号65829-28-9 2,3,4-trifluoro...

合成工艺路线路线简述

    2,3,4-三氟苯胺置于氢溴酸,Magnesium,Copper(I) Bromide,Sodium Nitrite体系中,化学反应生成2,3,4-三氟甲苯
    参考文献:Novel 5-Amino-6-Methylquinolone Antibacterials: A New Class Of Non-6-Fluoroquinolones
    标题:Novel 5-Amino-6-Methylquinolone Antibacterials: A New Class Of Non-6-Fluoroquinolones
    摘要:A Novel 5-Amino-6-Methylquinoline Carboxylic Acid Was Synthesized From 2,3,4-Trifluoro Aniline In 12 Steps And Coupled With Various Types Of Amines To Furnish New Quinolone Antibacterial Agents. Depending On The Structure Of Amine,Some Of Quinolones Showed Comparable Activity To Ciprofloxacin Or Better Gram Positive Activity Than Ciprofloxacin,Demonstrating That The C6 Fluorine Atom Is Not A Necessary Requirement For Good Antibacterial Potency. (C) 1997 Elsevier Science Ltd.
    Doi:10.1016/s0960-894X(97)00324-7

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    专利信息


    专利号:US-2021053913-A1
    优先权日:2019-08-22
    标题 :Process for the Synthesis of Fluorinated Conductive Salts for Lithium Ion Batteries
    发明人:ZHOU CHANGYUE; DU HONGJUN; WU WENTING
    权利人:FUJIAN YONGJING TECH CO LTD
    摘要:The invention relates to a new process for the synthesis of fluorinated conductive salts for lithium ion batteries (Li-ion batteries). The said fluorinated conductive lithium ion (Li-ion) battery salts of interest in the framework of the present inventions synthesis process, for example, are Li-ion salts such as LiFSI (lithium bis-(fluoromethanesulfonlyl) imide), LiTFSI (lithium bis-(trifluormethanesulfonlyl) imide), and LiTFSFI (lithium trifluoromethanesulfonylfluorosulfonyl imide), with the formulas as displayed in the Table I herein below. LiFSI, LiTFSI and LiFSTFSI are the most promising conducting salts for Lithium ion batteries and essential for future electromobility.

    专利号:US-2019292310-A1
    优先权日:2018-03-20
    标 题:Synthesis of high density molecular dna brushes via organic-phase ring-opening metathesis (co)polymerization
    发明人:ZHANG KE; TAN XUYU
    权利人:UNIV NORTHEASTERN
    摘要:The invention provides novel synthetic methods for oligonucleotide polymerization reactions that separate the deprotection and cleavage step following solid-phase oligonucleotide synthesis into two separate steps, thereby providing fully protected hydrophobic oligonucleotides that can be further manipulated in organic solvents. The disclosed methods enable the synthesis of new structures, such as brush DNA and brush RNA polymers and micellar spherical nucleic acids (SNAs

    专利号:US-2023287032-A1
    优先权日:2020-08-14
    标 题:Synthesis of fluorinated nucleotides
    发明人:CHUNG CHEOL KEUN; LIU ZHIJIAN; MALIGRES PETER E; MAO EDNA; OBLIGACION JENNIFER V; PHILLIPS ERIC M; PIRNOT MICHAEL; POIRIER MARC; SONG ZHIGUO JAKE; WANG TAO
    权利人:CHUNG CHEOL KEUN; LIU ZHIJIAN; MALIGRES PETER E; MAO EDNA; OBLIGACION JENNIFER V; PHILLIPS ERIC M; PIRNOT MICHAEL; POIRIER MARC; SONG ZHIGUO JAKE; WANG TAO; MERCK SHARP & DOHME LLC
    摘要:The present invention relates to efficient processes useful in the preparation of fluorinated nucleosides, such as (O—{[(2R,3R,4S,5R)-5-(6-amino-9H-purin-9-yl)-4-fluoro-3-hydroxyoxolan-2-yl]methyl}O,O-dihydrogen phosphorothioate, also known as 2′-(S)-fluoro-thio-adenosine monophosphate or 2′-F-thio-AMP. Such fluorinated nucleosides may be useful as a biologically active compound and or as an intermediate for the synthesis of more complex biologically active compounds. The present invention also encompasses intermediates useful in the disclosed synthetic processes and the methods of their preparation.

    专利号:US-10669292-B2
    优先权日:2014-05-05
    标 题 :Synthesis of boronate salts and uses thereof
    发明人:HECKER SCOTT; BOYER SERGE
    权利人:REMPEX PHARMACEUTICALS INC
    摘要:Disclosed herein are boronate intermediates in the synthesis of antimicrobial compounds and the use and preparation thereof. Some embodiments relate to crystalline boronate salt derivatives and their use in the synthesis of therapeutic compounds.

    专利号:US-2010191010-A1
    优先权日:2007-07-02
    标题 :Process for the synthesis of carbamates using co2
    发明人:BOSMAN JORIS KAREL PETER; CARR ROBERT HENRY
    权利人:HUNTSMAN INT LLC
    摘要:Process for the synthesis of non cyclic carbamate derivatives from amine compounds, alcohols and CO 2 in the presence of ionic liquids and optionally in the presence of a base.

    专利号:US-12054508-B1
    优先权日:2019-04-16
    标 题 :Compositions and methods for sulfation of carbohydrates and peptides via electron-deficient aryl sulfate diesters
    发明人:NIU JIA; LIU CHAO; YANG CANGJIE
    权利人:THE TRUSTEES OF BOSTON COLLEGE
    摘要:In one aspect, the disclosure relates to a facile strategy to introduce electron-deficient aryl sulfate diesters to silylated hydroxyl groups of carbohydrates and amino acids, among other substrates, wherein selective hydrolysis and the removal of an electron-deficient aromatic group allows for the efficient generation of sulfated carbohydrates, peptides, and other compounds. The incorporation of electron-deficient aryl sulfate diesters in the early stage of the synthesis of glycans, peptides, and the like, disclosed herein avoids time-consuming protecting group manipulations, simplifies the purification of sulfated products, and improves the overall yield and efficiency. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure.
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    主要参考文献

    [参考文献]: Simon Hammann, Et Al. Accelerated Separation Of Gc-Amenable Lipid Classes In Plant Oils By Countercurrent Chromatography In The Co-Current Mode. Anal Bioanal Chem. 2015 Dec;407(30):9019-28.

    合成参考文献


    参考文献:10.2174/1874104500701010004|10.2174/187410450701014054
    摘要:Benaka Prasad SB, Sunil Kumar YC, Ananda Kumar CS, Sadashiva CT, Vinaya K, Rangappa KS. Synthesis of Novel 3-Aryl-N-Methyl-1,2,5,6-Tetrahydropyridine Derivatives by Suzuki coupling: As Acetyl Cholinesterase Inhibitors. TOMCJ. 2007 Nov 30;1(1):4–10. doi: 10.2174/187410450701014054.
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