CAS: 1435-48-9; 2,4-Dichloro-1-Fluorobenzene

相似化合物

36556-33-9 2253-30-7 2268-05-5

上下游产品

CAS号554-00-7 2,4-二氯苯胺 | CAS号68716-47-2 2,4-二氯苯硼酸 | CAS号70-34-8 2,4-二硝基氟苯 | CAS号367-21-5 3-氯-4-氟苯胺 | CAS号350-30-1 3-氯-4-氟硝基苯 | CAS号350-46-9 对氟硝基苯 | CAS号36556-50-0 2,3-二氯氟苯 | CAS号462-06-6 氟苯 | CAS号420-56-4 三甲基氟硅烷 | CAS号86522-89-6 2,4-二氯-5-氟苯甲酸 | CAS号86393-33-1 环丙羧酸 | CAS号86483-51-4 2,4-二氯-5-氟-Β-氧代苯丙酸乙酯 | CAS号78725-51-6 4-(2,4-二氯苯氧基)苯甲醛 | CAS号704-10-9 2,4-二氯-5-氟苯乙酮 | CAS号120-83-2 2,4-二氯苯酚 | CAS号1481-63-6 2,4-二氯-5-氟溴苯 | CAS号2105-59-1 1,5-二氯-2-氟-4-硝基苯

3-氯-4-氟硝基苯置于氯体系中,化学反应 8.0H,以91.7%的收率获得2,4-二氯氟苯
参考文献:一种以邻二氯苯为原料联产喹诺酮类药物关键 中间体的方法
标题:一种以邻二氯苯为原料联产喹诺酮类药物关键 中间体的方法
摘要:本发明涉及医药中间体的制备方法领域,特别是涉及喹诺酮类药物关键中间体的制备方法领域,开发了一种以邻二氯苯为原料联产喹诺酮类药物关键中间体的方法.本发明方法以邻二氯苯为原料,硝化后经精馏提纯再分步结晶得到2,3-二氯硝基苯和3,4-二氯硝基苯.2,3-二氯硝基苯经氟化反应得到2-氟-3-氯硝基苯,然后氯化得到2,6-二氯氟苯,再硝化得到2,4-二氯-3-氟硝基苯,最后氟化得到2,3,4-三氟硝基苯.3,4-二氯硝基苯经氟化反应得到4-氟-3-氯硝基苯,然后氯化得到2,4-二氯氟苯,最后与乙酰氯发生酰化反应得到2,4-二氯-5-氟苯乙酮.

专利信息

专利号:US-7393980-B2
优先权日:2001-05-17
标题:Use of a composition of an ionic nature as a substrate reagent, a composition constituting a fluorination reagent and a method using same
发明人：GARAYT MAXIME; LE BOULAIRE VIRGINIE; GREE DANIELLE; GREE RENE; SCHANEN VINCENT; SPINDLER JEAN-FRANCIS
权利人:RHODIA CHIMIE SA
摘要:The invention relates to a novel method for producing nucleophilic substitutions, particularly of type SNAr and SN2. More specifically, the invention relates to the use as a fluorinating reaction medium of ionic liquid or fused salt comprising at least four carbon atoms. The invention can be used for the synthesis of fluoride derivatives.

专利号:US-7217842-B2
优先权日:2001-04-12
标题:Catalysts for nucleophilic substitution, synthesis thereof, composition containing them and use thereof
发明人：SCHANEN VINCENT; CRISTAU HENRI-JEAN; TAILLEFER MARC
权利人:RHONE POULENC CHIMIE
摘要:The invention concerns novel catalysts for aromatic nucleophilic substitution. Said catalysts are compounds of the general formula (I), wherein: R 1 , R 2 , R 3 , R 4 , R 5 , and R 6 , identical or different, are selected among hydrocarbon radicals; the Pn's, advantageously the same, are selected among metalloid elements of column V of a period higher than nitrogen; Z is a metalloid element of column V, advantageously distinct from Pn; preferably a nitrogen (N, P, As, Sb). The invention is applicable to organic synthesis

专利号:WO-2010058421-A2
优先权日:2008-11-18
标题:A process for synthesis of 2, 4-dichloro-5- fluoroacetophenone (dcfa)

专利号:CN-105130744-A
优先权日:2015-08-19
标题 :Synthesis of 1,3,5-trichloro-2,4,6-trifluorobenzene from a 2,4-difluoro-3,5-dichloronitrobenzene

专利号:EP-0376870-A1
优先权日:1988-12-30
标 题:A new organosilylpolyphosphoric reagent, its preparation and application to the process of synthesis of 3-carboxyquinolones or azaquinolones and their salts

专利号:CN-1007150-B
优先权日:1987-06-22
标题 :Synthesis of 2,4-dichlor-5-fluor benzoic acid