CAS: 142569-69-5; Methyl (S)-2-(3-(3-(2-(7-Chloroquinolin-2-yl)Vinyl)Phenyl)-3-Hydroxypropyl)Benzoate

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142569-70-8 1258428-71-5 150026-72-5

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CAS号133791-17-0 2-[3-(R)-[3-[2-... | CAS号149968-11-6 (E)-2-[3-[3-[2-...

专利信息

专利号:WO-2011121091-A1
优先权日:2010-03-31
标题:Efficient synthesis for the preparation of montelukast and novel crystalline form of intermediates therein
发明人：KIDEMET DAVOR; BOGDAN STEFANE; KLJAJIC ALEN; BENKIC PRIMOZ; STROPNIK TADEJ; PLAPER IGOR
权利人:KRKA D D NOVO MESTO; KIDEMET DAVOR; BOGDAN STEFANE; KLJAJIC ALEN; BENKIC PRIMOZ; STROPNIK TADEJ; PLAPER IGOR
摘要:The present invention describes the improved process for the preparation of montelukast acid (VII) and its pharmaceutically acceptable salts and esters using a novel synthesis step. The process is cost effective, environment friendly, and easily scale up to commercial level and leads to products having high chemical and optical purity. Moreover, the present invention provides a novel crystalline intermediate (IV) that is useful in this process and a method for its production. In a further aspect, the process of the present invention includes a step of removing ketone by-products be derivatization.

专利号:WO-2009010230-A2
优先权日:2007-07-13
标 题:Process and intermediate for the production of a tertiary alcohol as an intermediate in the synthesis of montelukast

专利号:US-9062085-B2
优先权日:2010-09-10
标 题 :Biaryl diphosphine ligands, intermediates of the same and their use in asymmetric catalysis
发明人：ABDUR-RASHID KAMALUDDIN; JIA WENLI; LU SHUIMING; GUO RONGWEI; CHEN XUANHUA; AMOROSO DINO
权利人:ABDUR-RASHID KAMALUDDIN; JIA WENLI; LU SHUIMING; GUO RONGWEI; CHEN XUANHUA; AMOROSO DINO; KANATA CHEMICAL TECHNOLOGIES INC
摘要:The present disclosure relates to biaryl diphosphine ligands of the formula (B), processes for the production of the ligands and the use of the ligands in metal catalysts for asymmetric synthesis. The disclosure also relates to intermediates used for the production of the biaryl diphosphine ligand. (Formula (B))

专利号:US-7786138-B2
优先权日:2005-11-18
标题 :Process for making montelukast and intermediates therefor
发明人：BENOVSKY PETR; THIJS LAMBERTUS; OVEREEM ARJANNE; CASTULIK JAKUB; ZHU JIE; BARTOS PETR; SKOUMAL RADOMIR
权利人:SYNTHON BV
摘要:A compound of the following formula n nwherein R′ is a straight or branched C1-C4 alkyl group is useful in processes associated with the synthesis of montelukast and its salts.

专利号:EP-2287154-A1
优先权日:2009-07-14
标题 :Efficient synthesis for the preparation of montelukast
发明人：KIDEMET DAVOR; BENKIC PRIMOZ; KLJAJIC ALEN; STEFANE BOGDAN
权利人:KRKA D D NOVO MESTO
摘要:The present invention describes the improved process for the preparation of montelukast acid and its pharmaceutically acceptable salts and esters. The process is cost effective, environment friendly, and easily scale up to commercial level.

专利号:EP-2178841-A2
优先权日:2007-07-13
标题 :Process and intermediate for the production of a tertiary alcohol as an intermediate in the synthesis of montelukast