CAS: 1403-17-4; Candicidin (200 Mg)
该化合物是来自Streptocepies Griseus的多元聚苯大型硫化物抗生素,主要用于抗硫素特性;它展示了针对多种病原真菌,特别是Candida物种的有力活动,在真菌细胞膜中与egosterol捆绑在一起,破坏膜膜完整性并导致细胞死亡;它抗抗菌株和生理条件下的稳定性使其在临床和研究环境中成为宝贵的治疗剂;Candiedin因系统吸收有限,尽量减少毒性风险,经常用于专题配方;它对于哺乳动物细胞的真菌细胞特性增强了其目标应用的安全性特征.
- 英文名称Candicidin (200 Mg)
- 中文名称杀念菌素
- IUPAC名称(10R,12S,14S,18S,19S,20S,22R,23E,25Z,27Z,29Z,31E,33E,35E,37S,38R)-22-(((2R,3S,4S,5S,6R)-4-amino-3,5-dihydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-38-((2S,4S,5S)-7-(4-aminophenyl)-5-hydroxy-4-methyl-7-oxoheptan-2-yl)-10,12,14,18,20-pentahydroxy-37-methyl-2,4,8,16-tetraoxooxacyclooctatriaconta-23,25,27,29,31,33,35-heptaene-19-carboxylic acid
- 其它别名candeptin; candicidin; candimon; candizidin; Candicidine; CARBOPRST; CANDICIDIN
- CAS编号1403-17-4
- EINECS号:215-763-7
- 分子式:C21H36O5分子量:368.51
- 产品CID: 622600
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专利信息
专利号:US-7595156-B2
优先权日:2003-10-23
标 题:Genes for synthesis of FR-008 polyketides
发明人：LEE SANG YUP; DENG ZIXIN; CHEN SHI; JEONG KI JUN; ZHOU XIUFEN
权利人:KOREA ADVANCED INST SCI & TECH
摘要:The present invention relates to the base sequence of whole genes involved in the biosynthesis of FR-008 polyketides derived from Streptomyces sp. FR-008. This base sequence comprises genes coding for ketosynthase (KS), acyl transferase (AT), acyl carrier protein (ACP), ketoreductase (KR), dehydratase (DH) and enoyl reductase (ER) domains, and genes coding for modifier enzymes, such as ABC transporter, cytochrome P450 monooxygenase, ferredoxin, thioesterase, sugar synthetic protein, FAD-dependent monooxygenase, 4-amino-4-deoxychorismate (ADC) synthase and ADC lyase. The gene base sequence according to the present invention can be used to increase the productivity of the existing FR-008 polyketides or produce new FR-008 polyketides, through modification of its parts.
专利号:US-6132993-A
优先权日:1995-08-11
标 题:Process for the production of amphotericin-B inhibiting production of amphotericin-A
发明人：SCHAFFNER CARL P; KIENTZLER DAVID J
权利人:UNIV RUTGERS
摘要:Methods are provided for improving the microbial production of amphotericin B by the selective inhibition of amphotericin A by means of protein synthesis inhibitors.
专利号:US-5710032-A
优先权日:1991-09-18
标 题 :Secondary-metabolite biosynthesis genes from actinomycetes, method of isolating them and their use
发明人：PIEPERSBERG WOLFGANG; BRAEU BARBARA; SICHEL PETRA
权利人:HOECHST AG
摘要:Secondary-metabolite biosynthesis genes from actinomycetes, method of isolating them, and their use. The invention concerns secondary-metabolite biosynthesis genes from actinomycetes, a method of isolating secondary-metabolite and, in particular, 6-deoxy-sugar bio-synthesis genes, from actinomycetes using the gene probes strD, strE, strL and strM gene probes from Streptomyces griseus DSM40236, and structurally related genes, as gene probes for detecting the genes snot (coding for amphotheronolide B-dTDP-D-mycosaminyl transferase), snoD (coding for dTDP-D-glucose synthase) and snoM (coding for dTDP-4-keto-6-deoxy-D-glucose isomerase), or one or more secondary-metabolite biosynthesis genes from actinomycetes. The invention also concerns the use of secondary-metabolite biosynthesis genes thus isolated.
专利号:US-2005089884-A1
优先权日:2003-10-23
标 题 :Genes for synthesis of FR-008 polyketides
专利号:KR-20050083610-A
优先权日:2002-08-02
标 题:Dehydrophenylahistins and analogs thereof and the synthesis of dehydrophenylahistins and analogs thereof
专利号:KR-20110039500-A
优先权日:2002-08-02
标题:Dehydrophenylahistins and analogs thereof and the synthesis of dehydrophenylahistins and analogs thereof
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主要参考文献
1: Blackburn SA, Shepherd M, Robinson GK. The polyene antifungal candicidin is selectively packaged into membrane vesicles in Streptomyces S4. Arch Microbiol. 2022 Apr 30;204(5):289. doi: 10.1007/s00203-022-02906-w.
2: Králová S, Sandoval-Powers M, Fawwal DV, Degnes KF, Lewin AS, Klinkenberg G, Nguyen GS, Liles MR, Wentzel A. Streptomyces tardus sp. nov.: A Slow- Growing Actinobacterium Producing Candicidin, Isolated From Sediments of the Trondheim Fjord. Front Microbiol. 2021 Aug 4;12:714233. doi: 10.3389/fmicb.2021.714233.
3: Yao X, Zhang Z, Huang J, Wei S, Sun X, Chen Y, Liu H, Li S. Candicidin Isomer Production Is Essential for Biocontrol of Cucumber Rhizoctonia Rot by Streptomyces albidoflavus W68. Appl Environ Microbiol. 2021 Apr 13;87(9):e03078-20. doi: 10.1128/AEM.03078-20.
合成参考文献
摘要:Progress in Medical Chemistry., 14(105), 1977 []
摘要:Antibiotics Annual., 2(980), 1954/1955
摘要:Kovtuniak NA, Bordiakovskaia LG, Petrova IV. [Effect of decamethoxin, decamine and levorin on the carbohydrate-protein component content in the liver connective tissue of white rats]. Farmakol Toksikol. 1980 Jan;43(1):88–91.
参考文献:10.1001/archderm.1954.01540190003001
摘要:HU F, LIVINGOOD CS, JOHNSON P, POMERAT CM. Tissue culture studies on human skin. V. Conjoint culture of Candida albicans, human skin, and embryonic chick heart; inhibitory effects of endomycin, candicidin A, and asterol on C albicans grown conjointly with human skin and embryonic chick heart. AMA Arch Derm Syphilol. 1954 Jul;70(1):1–15. doi: 10.1001/archderm.1954.01540190003001.
摘要:OKAMI Y, UTAHARA R, NAKAMURA S, UMEZAWA H. Studies on antibiotic actinomycetes. IX. On Streptomyces producing a new antifungal substance mediocidin and antifungal substances of fungicidin-rimocidin-chromin group, eurocidin group and trichomycin-ascosin-candicidin group. J Antibiot (Tokyo). 1954 May;7(3):98–103.
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