CAS: 123-41-1; Choline Hydroxide

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合成工艺路线路线简述

    📜Alkaline Earth Salt Of/the/ Methylsulfuric Acid 反应生成胆碱
    参考文献:Oya,Biochemische Zeitschrift,1929,Vol. 215,P. 366
    标题:Oya,Biochemische Zeitschrift,1929,Vol. 215,P. 366

    海关参考信息

    专利信息


    专利号:US-7344863-B2
    优先权日:1998-03-13
    标题:Methods for producing polypeptides through enhanced synthesis of encoding nucleic acid molecules
    发明人:LI WU-BO; JESSEE JOEL A; SCHUSTER DAVID; XIA JIULIN; GEBEYEHU GULILAT
    权利人:INVITROGEN CORP
    摘要:The present invention is directed to compositions and methods for enhancing synthesis of nucleic acid molecules, particularly GC-rich nucleic acid molecules. Specifically, the invention provides compositions comprising one or more nitrogen-containing organic compounds having a formula selected from the group consisting of formula I and formula II (or salts or derivatives thereof), preferably 4-methylmorpholine N-oxide or betaine (carboxymethyltrimethylammonium), and further comprising one or more compounds selected from the group consisting of proline and an N-alkylimidazole compound, and more preferably proline, 1-methylimidazole or 4-methylimidazole. The invention further relates to methods for enhanced, high-fidelity synthesis of nucleic acid molecules, including via amplification (particularly PCR), reverse transcription, and sequencing methods. The invention also relates to nucleic acid molecules synthesized by these methods, to fragments or derivatives thereof, and to vectors and host cells comprising such nucleic acid molecules, fragments, or derivatives. The invention also relates to kits for synthesizing, amplifying, reverse transcribing or sequencing nucleic acid molecules comprising one or more of the compositions of the invention.

    专利号:US-10865116-B2
    优先权日:2017-03-24
    标 题:Process for the synthesis of IZM-2 zeolite in the presence of a template, 1,6-bis(methylpiperidinium)hexane dihydroxide
    发明人:MARTINEZ FRANCO RAQUEL; BATS NICOLAS
    权利人:IFP ENERGIES NOW
    摘要:A novel process is described for the preparation of a microporous crystalline solid, known as IZM-2 microporous solid or IZM-2 zeolite. This novel process consists of carrying out the synthesis of IZM-2 zeolite by conversion/transformation of a zeolite with structure type FAU in a fluorinated medium under hydrothermal conditions. In particular, said novel process consists of carrying out the synthesis of an IZM-2 zeolite in a fluorinated medium starting from a zeolite with structure type FAU used as the source of silicon and aluminium and a specific organic molecule or template comprising two quaternary ammonium functions, namely 1,6-bis(methylpiperidinium)hexane dihydroxide.

    专利号:US-10875778-B2
    优先权日:2017-03-24
    标 题 :Process for the synthesis of IZM-2 zeolite in the presence of a template, 1,6-bis(methylpiperidinium)hexane dibromide
    发明人:MARTINEZ FRANCO RAQUEL; BATS NICOLAS
    权利人:IFP ENERGIES NOW
    摘要:A novel process is described for the preparation of a microporous crystalline solid, known as IZM-2 microporous solid or IZM-2 zeolite. This novel process consists of carrying out the synthesis of IZM-2 zeolite by conversion/transformation of a zeolite with structure type FAU under hydrothermal conditions. In particular, said novel process consists of carrying out the synthesis of an IZM-2 zeolite starting from a zeolite with structure type FAU used as the source of silicon and aluminium and a specific organic molecule or template comprising two quaternary ammonium functions, namely 1,6-bis(methylpiperidinium)hexane dibromide.

    专利号:WO-2025109557-A1
    优先权日:2023-11-24
    标题:Process for the synthesis of monoesters of ethylenediaminetetraacetic acid
    发明人:TERAZONO YUICHI
    权利人:NUTRIEN AG SOLUTIONS CANADA INC
    摘要:A process for the synthesis of a compound of Formula (I) is provided. (I) wherein R is selected from the group consisting of alkyl, alkenyl, alkynyl, and steroidyl. The process comprises reacting a compound of Formula (IIa), Formula (IIb) or a mixture thereof with a compound of Formula R-X, to obtain a compound of Formula (IIIa), a compound of Formula (IIIb) or a mixture thereof, wherein A+ is a cesium cation, a quaternary ammonium cation or a quaternary phosphonium cation, and X is a leaving group; and reacting the compound of Formula (IIIa), compound of Formula (IIIb) or mixture thereof with an acid to obtain a reaction product which comprises the compound of Formula (I). (IIa) (IIb) (IIIa) (IIIb)

    专利号:US-5684191-A
    优先权日:1996-10-31
    标 题 :Process for the combined synthesis of betaine and choline chloride
    发明人:BELLIS HAROLD EDWARD; JEMISON THOMAS ROBERT; MATHRE OWEN B
    权利人:DUCOA LP
    摘要:A process for the combined synthesis of betaine and choline chloride from monochloroacetic acid, trimethylamine and ethylene oxide by first reacting trimethylamine with monochloroacetic acid, and then reacting ethylene oxide with the reaction product from the previous step.

    专利号:WO-2025097020-A1
    优先权日:2023-11-02
    标题:Process for polyethylene glycol synthesis
    发明人:WANG PENG; ZHANG CHENGZHI; GUO ZHIWEI; SONG LICHENG
    权利人:DESIGN THERAPEUTICS INC
    摘要:The present disclosure relates to a process for the synthesis of polyethylene glycol (PEG) derivatives.

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    主要参考文献


    1: Kwatra NS, Nurko S, Stamoulis C, Falone AE, Grant FD, Treves ST. Chronic Acalculous Cholecystitis in Children with Biliary Symptoms: Usefulness of Hepato-Cholescintigraphy. J Pediatr Gastroenterol Nutr. 2018 Sep 25. doi: 10.1097/MPG.0000000000002151. [Epub ahead of print] doi: 10.11817/j.issn.1672-7347.2018.01.003. Chinese. doi: 10.1016/j.lfs.2018.08.003. Epub 2018 Aug 4. doi: 10.1016/j.toxlet.2018.07.047. Epub 2018 Jul 25. Available from http://www.ncbi.nlm.nih.gov/books/NBK500758/ doi: 10.1590/1414-431x20187220. Epub 2018 May 7.
    7: Tang JC, Ren YG, Zhao J, Long F, Chen JY, Jiang Z. Shikonin enhances sensitization of gefitinib against wild-type EGFR non-small cell lung cancer via inhibition PKM2/stat3/cyclinD1 signal pathway. Life Sci. 2018 Jul 1;204:71-77. doi: 10.1016/j.lfs.2018.05.012. Epub 2018 May 5. Chinese. doi: 10.1007/s13577-018-0206-1. Epub 2018 Apr 20. doi: 10.1016/j.bios.2018.03.041. Epub 2018 Mar 21. doi: 10.1691/ph.2018.7819. doi: 10.1097/RLU.0000000000001983. doi: 10.4103/0366-6999.220307.
    14: Rose JB, Fields RC, Strasberg SM. Poor Reproducibility of Gallbladder Ejection Fraction by Biliary Scintigraphy for Diagnosis of Biliary Dyskinesia. J Am Coll Surg. 2018 Feb;226(2):155-159. doi: 10.1016/j.jamcollsurg.2017.10.025. Epub 2017 Nov 17. doi: 10.1016/j.archoralbio.2017.10.024. Epub 2017 Oct 31. doi: 10.1159/000484121. Epub 2017 Oct 20. doi: 10.1159/000484075. Epub 2017 Oct 19. doi: 10.1016/j.nut.2017.06.020. Epub 2017 Jul 6. doi: 10.1371/journal.pone.0184348. eCollection 2017.

    合成参考文献


    摘要:Walker, J. C. L., Science of Synthesis: Knowledge Updates, (2024) 3, 208.
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