CAS: 111755-37-4; (5R,8S,11R,12S,15S,18S,19S,22R)-8,15-Bis(3-Guanidinopropyl)-18-((1E,3E,5S,6S)-6-Methoxy-3,5-Dimethyl-7-Phenylhepta-1,3-Dien-1-yl)-1,5,12,19-Tetramethyl-2-Methylene-3,6,9,13,16,20,25-Heptaoxo-1,4,7,10,14,17,21-Heptaazacyclopentacosane-11,22-Dicarboxylic Acid

专利信息

专利号:US-2022133840-A1
优先权日:2020-10-30
标题:Use of microcystin in preparation of drug for preventing or treating organ and tissue fibrosis diseases
发明人：WANG YAPING; XU LIZHI; WANG JIE; Zhao qingya
权利人:NANJING UNIVERSITY OF TECHNOLOGY
摘要:Use of microcystins having a monocyclic heptapeptide structure in preparation of drugs for preventing or treating organ and tissue fibrosis diseases. Preferably, the microcystins are microcystin-LR with amino acids at positions 2 and 4 of a monocyclic heptapeptide structure thereof being leucine and arginine respectively, or are microcystin-RR with amino acids at positions 2 and 4 thereof being both arginine. Also provided is a method for inhibiting myofibroblast differentiation and collagen synthesis. The method is implemented by inhibiting a TGF-β/Smad signaling pathway by using one or more microcystins.

专利号:US-7582455-B2
优先权日:2005-04-26
标 题:Polypeptides and biosynthetic pathways for the production of stereoisomers of monatin and their precursors
发明人：BRAZEAU BRIAN J; BURKE ELLEN; DESOUZA MERVYN; GORT STEVEN J; HICKS PAULA M; KOLLMANN SHERRY R; LUGINBUHL PETER; MCFARLAN SARA C; RICHARDSON TOBY; SANCHEZ-RIERA FERNANDO A; SOLHEID CHRISTOPHER; WEINER DAVID; ZHAO LISHAN
权利人:CARGILL INC
摘要:Monatin and certain stereoisomers of monatin, such as R,R monatin and S,R monatin, as well as salts thereof, are produced using polypeptides and biosynthetic pathways. These polypeptides and biosynthetic pathways are also useful in the production of R-2-hydroxy-2-(indoly-3-ylmethyl)-4-keto glutaric acid, an intermediate that is formed in certain monatin synthesis pathways, including some biosynthetic pathways.