CAS: 1007-16-5; 3-Bromo-4-Fluorobenzoic Acid

相似化合物

82702-31-6 23233-33-2 375368-94-8

上下游产品

CAS号77771-02-9 3-溴-4-氟苯甲醛 | CAS号456-22-4 对氟苯甲酸 | CAS号452-62-0 3-溴-4-氟甲苯 | CAS号352-32-9 对氟甲苯 | CAS号13194-71-3 2-溴-4-甲基苯胺盐酸盐 | CAS号369-26-6 3-氨基-4-氟苯甲酸甲酯 | CAS号23233-33-2 3-溴-4-氟苯甲酸乙酯 | CAS号82702-31-6 3-溴-4-氟苯甲酸甲酯 | CAS号77771-03-0 3-溴-4-氟苄胺盐酸盐 | CAS号288309-07-9 2-氟-5-乙酰基苯甲腈 | CAS号836619-77-3 N-B°C-3-溴-4-氟苯胺 | CAS号656-64-4 3-溴-4-氟苯胺 | CAS号672-75-3 3-溴-4-氟苯甲酰氯 | CAS号1007-15-4 3'-溴-4'-氟苯乙酮 | CAS号1072-85-1 1-溴-2-氟苯

对氟甲苯置于四氯化碳,Potassium Permanganate,水,溴,铁粉体系中,化学反应生成3-溴-4-氟苯甲酸
参考文献:Varma; Raman; Nilkantiah,Journal Of The Indian Chemical Society,1944,Vol. 21,P. 112,114
标题:Varma; Raman; Nilkantiah,Journal Of The Indian Chemical Society,1944,Vol. 21,P. 112,114

专利信息

专利号:US-4383949-A
优先权日:1980-07-16
标题:Preparation of 3-bromo-4-fluorobenzaldehyde and its acetals
发明人：MAURER FRITZ; RIEBEL HANS-JOCHEM; PRIESNITZ UWE; KLAUKE ERICH
权利人:BAYER AG
摘要:A process for the preparation of a 3-bromo-4-fluorobenzaldehyde acetal of the formula ##STR1## in which R 1 is methyl or ethyl, n which comprises reacting a 3-bromo-4-fluoro-benzoic acid halide with ammonia to form 3-bromo-4-fluoro-benzoic acid amide, dehydrating said amide to form 3-bromo-4-fluoro-benzonitrile, reacting the nitrile with formic acid in the presence of a catalyst at a temperature between about 0° and 150° C. to form 3-bromo-4-fluorobenzaldehyde, and reacting said aldehyde with R 1 OH or a derivative thereof capable of forming an acetal. The amide and nitrile are new compounds. The acetals are known intermediates in the synthesis of pyrethroid-like insecticides.

专利号:US-4446075-A
优先权日:1980-02-22
标 题:Substituted bromofluorobenzene derivatives and process for its manufacture
发明人：EIGLMEIER KURT; KNIEPS REINHARD
权利人:RIEDEL DE HAEN AG
摘要:Substituted bromofluorobenzene, wherein the fluorine is in para-position and the bromine in meta-position to another substituent, is prepared by direct bromination of the corresponding fluorobenzene derivative. Bromination is advantageously carried out in the presence of a catalyst, preferably a metal or metal salt. The elementary bromine is used in an amount of 0.9 to 1.3 mols per mol of fluorobenzene derivative and the reaction temperature is between 20° and 200° C. The bromofluorobenzene derivatives are suitable for the synthesis of medicaments and plant protective agents.

专利号:US-12227528-B2
优先权日:2017-11-09
标 题:Glucose-sensitive albumin-binding derivatives
发明人：KRUSE THOMAS; KOFOD-HANSEN MIKAEL; MUENZEL MARTIN WERNER BORCHSENIUS; THOEGERSEN HENNING; SAUERBERG PER; EWALD JAKOB; BEHRENS CARSTEN; HOEG-JENSEN THOMAS; BALSANEK VOJTECH; DROBNAKOVA ZUZANA; DROZ LADISLAV; HAVRANEK MIROSLAV; KOTEK VLADISLAV; STENGL MILAN; SNAJDR IVAN; DRUSANOVA HANA
权利人:NOVO NORDISK AS
摘要:This invention relates to glucose-sensitive albumin-binding diboron conjugates. More particularly the invention provides novel diboron compounds, and in particular diboronate or diboroxole compounds, useful as intermediate compounds for the synthesis of diboron conjugates.

专利号:US-11299484-B2
优先权日:2018-10-10
标 题 :Inhibiting fatty acid synthase (FASN)
发明人：MARTIN MATTHEW W; ZABLOCKI MARY-MARGARET; MENTE SCOT; DINSMORE CHRISTOPHER; WANG ZHONGGUO; ZHENG XIAOZHANG
权利人:FORMA THERAPEUTICS INC
摘要:The present disclosure is directed to inhibitors of FASN. The compounds can be useful in the treatment of disease or disorders associated with the inhibition of FASN. For instance, the disclosure is concerned with compounds and compositions for inhibition of FASN, methods of treating, preventing, or ameliorating diseases or disorders associated with the inhibition of FASN, and methods of synthesis of these compounds.

专利号:US-9217012-B2
优先权日:2009-04-08
标题 :Inhibitors of protein tyrosine phosphatases
发明人：ZHANG ZHONG-YIN; ZHANG SHENG
权利人:ZHANG ZHONG-YIN; ZHANG SHENG; UNIV INDIANA RES & TECH CORP
摘要:Disclosed herein are compounds that selectively inhibit members of the PTP family of enzymes. Synthesized compounds demonstrated selective inhibition of TC-PTP. Also provided are methods of using the compounds and formulations containing the compounds. Also described is a fluorescence-tagged combinatorial library synthesis and screening method. And methods of using these compounds to effect enzyme activity both in cells and in vitro as well as method of using these compounds to treat diseases in human and animals.

专利号:US-2012202787-A1
优先权日:2009-10-20
标 题:Novel Heteroaryl Imidazoles And Heteroaryl Triazoles As Gamma-Secretase Modulators
发明人：AM ENDE CHRISTOPHER WILLIAM; JOHNSON DOUGLAS SCOTT; PETTERSSON MARTIN YOUNGJIN; SUBRAMANYAM CHAKRAPANI; O'DONNELL CHRISTOPHER JOHN
权利人:AM ENDE CHRISTOPHER WILLIAM; JOHNSON DOUGLAS SCOTT; PETTERSSON MARTIN YOUNGJIN; SUBRAMANYAM CHAKRAPANI; O'DONNELL CHRISTOPHER JOHN; PFIZER
摘要:Compounds and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula I; n n n n n n n n n n as defined in the specification. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.