CAS: 10034-20-5; (2S,3R,4R,5S,6R)-6-(Acetoxymethyl)-3-Aminotetrahydro-2H-Pyran-2,4,5-Triyl Triacetate Hydrochloride

上下游产品

(2S,3R,4R,5S,6R)-6-(acetoxymethyl)-3-((E)-(4-methoxybenzylidene)amino)tetrahydro-2Hpyran-2,4,5-triyl triacetate 1,3,4,6-tetra-O-acetyl-2-deoxy-2-(4-methoxybenzylidene)amino-β-D-glucopyranose 1,3,4,6-tetra-O-acetyl-2-deoxy-2-{[(4-methoxyphenyl)methylidene]amino}-D-glucopyranose -2-deoxy-D-glucopyranose2--2-deoxy-D-glucopyranose 1,3,4,6-tetra-O-acetyl-2-deoxy-2-(3-phenylureido)-β-D-glucopyranose 2-(acetoxymethyl)-5-{[(benzyloxy)carbonyl]amino}tetrahydropyran-3,4,6-triyl triacetate 2-acetamido-1,3,4,6-tetra-O-acetyl-2-deoxy-β-D-glucopyranose 1,3,4,6-Tetra-O-acetyl-2-(2,4-dinitroanilino)-2-desoxy-β-D-glucopyranose

📜1,3,4,6-Tetra-O-Acetyl-2-Deoxy-2-(4-Methoxybenzylidene)Amino-D-α-Glucopyranose置于盐酸体系中,用 丙酮 用作溶剂,以82%的收率获得1,3,4,6-四-O-乙酰基-2-氨基-2-脱氧-β-D-葡萄糖盐酸盐
参考文献:2-氨基-2-脱氧-D-葡萄糖的n-烷氧羰基衍生物在糖基化反应中作为供体的用途
标题:2-氨基-2-脱氧-D-葡萄糖的n-烷氧羰基衍生物在糖基化反应中作为供体的用途
摘要:1,3,4,6-四-O-乙酰基-2-烷氧基羰基氨基-2-脱氧-β-D-Glu复制糖和3,4,6-三-O-乙酰基-2-烷氧基羰基氨基-2-脱氧-α在与模型醇的糖基化反应中,已将-D-吡喃葡萄糖烷基溴用作供体.β-糖苷以高收率和高度的1,2-反式立体选择性获得.恶唑烷酮是一些吡喃葡萄糖基溴化物与低反应性醇反应形成的主要产物,但所有产物的形成都可以通过烷氧基羰基氨基的强烈参与来解释.
Doi:10.1016/0008-6215(90)84077-8

专利信息

专利号:US-9550001-B2
优先权日:2011-06-20
标 题 :Compositions, methods of synthesis and use of carbohydrate targeted agents
发明人：TWOROWSKA IZABELA; SIMS-MOURTADA JENNIFER; DELPASSAND EBRAHIM S
权利人:TWOROWSKA IZABELA; SIMS-MOURTADA JENNIFER; DELPASSAND EBRAHIM S; RADIOMEDIX INC
摘要:The invention provides D02S derivatives conjugated to monosaccharide ligands directly or through a linker and optionally chelated to a metal, wherein the D02S derivatives having the following structure: wherein R 1 ′, R 2 ′ are each independently —OH or —O-alkyl; R 1 is a hydrogen, a linker, or a ligand; R 3 is a linker and/or a ligand; and n is an integer from 1 to 10; the linker is an amino acid, a peptide, an amino alcohol, a polyethylylene glycol, an alkyl, an alkenyl, an alkynyl, an azide, an aromatic compound, a carboxylic acid, or an ester, the alkyl, alkenyl, or alkynyl is optionally substituted with an alkyl, a halogen, a nitro group, a hydroxyl group, an amino group, or a carboxyl group; the ligand is a GLUT1 targeting moiety.

专利号:US-2014228551-A1
优先权日:2011-06-20
标题 :Compositions, methods of synthesis and use of carbohydrate targeted agents

专利号:EP-2721045-B1
优先权日:2011-06-20
标 题:Compositions, methods of synthesis and use of carbohydrate targeted agents