CAS: 958452-00-1; 5-Bromoquinazoline
该化合物是一种杂交有机化合物,其特点是在五分环系统的五处位置上存在溴原子.Quinazoline本身是一个由苯环组成的双循环结构,该环与火水环结合,形成一个火水环,形成其芳香特性.该化合物通常表现出黄色和白色以外的固态,以其在有机溶剂中的中等溶解性闻名.5-Bromoquinazoline由于其潜在的生物活动,包括防癌和防炎特性,对医药化学具有兴趣.溴基质的分构成会影响该化合物的再活动及其与生物目标的相互作用.此外,它可作为各种药物和农业化学合成的有用中间体.与许多溴化化合物一样,在处理5-Bromoquinzoline时,由于潜在的毒性和与溴化有机化合物有关的环境关切,应采取安全防范措施.
- 英文名称5-Bromoquinazoline
- 中文名称5-溴喹唑啉
- IUPAC名称5-bromoquinazoline
- 其它别名5-Bromoquinazoline; Iaqnfopkxlqolr-Uhfffaoysa-N
- CAS编号958452-00-1
- MFCD编号:MFCD11036107
- 分子式:C8H5BrN2分子量:209.04
- 产品CID: 2012766
- 产品分类有机原料→分子砌块→芳杂环类化合物→喹唑啉类化合物
物理性质
MSDS等安全信息
合成工艺路线路线简述
专利信息
专利号:US-11840537-B2
优先权日:2020-11-03
标 题:Preparation and application of a 5-bromoquinazoline derivative
发明人：LUO MEI
权利人:LUO MEI; UNIV HEFEI TECHNOLOGY
摘要:A 5-bromoquinazoline derivative (I), structural formula thereof is as follows:the synthesis method thereof comprises weighing 1.18 g of 5-bromoisatin, 2.5503 g of ammonium formate and 100 ml of absolute methanol in a 250 mL round-bottom flask, heating, stirring and refluxing for 48 h, stopping reaction, rotating to obtain 1.6033 g of filter residue crude product, carrying out column chromatography separation by using dichloromethane and absolute methanol according to a volume ratio of 1:1, and obtaining a target crystal compound I; the application of the 5-bromoquinazoline derivative compound crystal (I), as a catalyst has a good catalytic effect in nitrile silicification reaction of benzaldehyde and auto-polymerization reaction of benzophenone hydrazone, the conversion rates thereof respectively reach 39% and 76%, and the crystal (I) can be used as an anti-cancer reagent which has certain anti-cancer activity of breast cancer, liver cancer and lung cancer.
