CAS: 923595-58-8; 5-Chloro-3-Iodopyrazolo[1,5-A]Pyrimidine
该化合物是一种杂交循环化合物,其特点是含有氯和碘替代物的独有的丙-丙结构,该化合物的特点是一个配有环的,它与一个环结合,有助于其潜在的生物活动;氯和碘原子的存在可以影响其再活动,溶性以及与生物目标的相互作用.一般而言,这种化合物由于其作为药物或农用化学品的潜力,对医药化学具有兴趣.卤素子子成分的子组可能提高分子的脂性和代谢稳定性,使之适合各种用途.此外,该化合物的结构可能允许与酶或感应器进行具体互动,这对生物系统的效率至关重要.与许多乙型循环,5-氯-3-狄皮拉佐罗索洛的合成和定性[15-a] 一样,这种化合物具有各种技术,包括NMR光谱谱和感应质学领域,从而确认其重要的整体特性和感光学区域.
相似化合物
754211-05-7 29274-24-6 57489-77-7物理性质
MSDS等安全信息
欧盟法规
C&L通报上下游产品
CAS号29274-24-6 5-氯吡唑并(1,5-a)嘧啶合成工艺路线路线简述
- 合成目标产物 5-Chloro-3-Iodopyrazolo[1,5-A]Pyrimidine 主要起始原料 5-Chloropyrazolo[1,5-A]Pyrimidine
- 29274-24-6 = 923595-58-8
反应条件:1.1 Reagents: N-Iodosuccinimide Solvents: Dimethylformamide; Overnight,Rt
标题:Preparation Of Pyrazolopyridine Compounds As Protein Kinase Modulators Useful For Treatment Of Hyperproliferative Disorders
参考文献:United States]
29274-24-6 = 923595-58-8
反应条件:1.1 Reagents: N-Iodosuccinimide Solvents: Dimethylformamide; Overnight,Rt
标题:Preparation Of Aryl-Heterocyclic Compounds For Treatment Of Hyperproliferative Disorders
参考文献:China]
29274-24-6 = 923595-58-8
反应条件:1.1 Reagents: N-Iodosuccinimide Solvents: Dimethylformamide; 4 H,Rt
标题:Discovery And Sar Of Novel Pyrazolo[1,5-A]Pyrimidines As Inhibitors Of Cdk9
作者:Phillipson,Louisa J.; Segal,David H.; Nero,Tracy L.; Parker,Michael W.; Wan,Soo San; Et Al
参考文献:Bioorganic & Medicinal Chemistry 日期:2015 卷标:23(19) 页码:6280-6296]
1820-80-0 + 874-14-6 = 923595-58-8
反应条件:1.1 Reagents: Sodium Methoxide1.2 Reagents: Phosphorus Oxychloride1.3 Reagents: N-Iodosuccinimide
标题:Discovery Of Pyrazolo[1,5-A]Pyrimidine-Based Pim Inhibitors: A Template-Based Approach
作者:Dwyer,Michael P.; Keertikar,Kartik; Paruch,Kamil; Alvarez,Carmen; Labroli,Marc; Et Al
参考文献:Bioorganic & Medicinal Chemistry Letters 日期:2013 卷标:23(22) 页码:6178-6182]
29274-24-6 = 923595-58-8
反应条件:1.1 Reagents: N-Iodosuccinimide Solvents: Dimethylformamide; Rt; 2 H,Rt1.2 Reagents: Water; 30 Min,Rt
标题:Preparation Of Fused Ring Heteroaryl Compounds And Their Use As Trk Inhibitors
参考文献:United States]
29274-24-6 = 923595-58-8
反应条件:1.1 Reagents: N-Iodosuccinimide Solvents: Dimethylformamide; 15 H,25 °C
标题:Preparation Of Imidazopyridine Derivatives Aak1 Inhibitor
参考文献:China]
29274-24-6 = 923595-58-8
反应条件:1.1 Reagents: N-Iodosuccinimide Solvents: Dimethylformamide; 4 H,Rt1.2 Reagents: N-(4-Methoxytricyclo[3.3.1.13,7]Dec-1-Yl)-3-(4-Pyridinyl)Pyrazolo[1,5-A]Pyrimidi... Solvents: Chloroform,Water; Rt
标题:Preparation Of Fused Heterocycles,Particularly Imidazopyridazines And Pyrazolopyrimidines,As Lck Inhibitors
参考文献:World Intellectual Property Organization]
= 923595-58-8 [标题:Reaction Conditions
标题:Preparation Of 7H-Pyrrolo[2,3-D]Pyrimidine Compounds As Dyrk1A Inhibitors
参考文献:World Intellectual Property Organization
📜5-氯吡唑并[1,5-A]嘧啶置于n-碘代丁二酰亚胺体系中,用 N,N-二甲基甲酰胺 作为反应溶剂,以100%的收率获得产物5-氯-3-碘吡唑并[1,5-A]嘧啶
参考文献:Heteroaromatic Compounds As Pi3 Kinase Modulators And Methods Of Use
标题:Heteroaromatic Compounds As Pi3 Kinase Modulators And Methods Of Use
摘要:本发明提供了杂环芳基衍生物及其药用可接受的盐和制剂,用于调节蛋白激酶活性,特别是磷脂酰肌醇3-激酶(pi3激酶)和mtor,并调节细胞内和/或细胞间信号活动,如增殖,分化,凋亡,迁移和侵袭.该发明还提供了包括这些化合物的药用可接受组合物以及在治疗哺乳动物,特别是人类的高增殖性疾病中使用这些组合物的方法.
