CAS: 86845-28-5; 1-Bromo-3-Methyl-5-(Trifluoromethyl)Benzene

3-溴-5-甲基苯甲酸置于sulfur Tetrafluoride,氢氟酸体系中,化学反应 24.0H,以93%的收率获得产物3-溴-5-甲基三氟甲苯
参考文献:(杂)芳族酸的脱氧氟化.
标题:(杂)芳族酸的脱氧氟化.
摘要:通过用四氟化硫对肉桂酸和(杂)芳族羧酸进行脱氧氟化反应,合成了不同的三氟甲基取代的化合物.所得产物用作制备新型氟化氨基酸,苯胺和脂肪胺的原料,这些氟化物是药物化学和农业化学的重要组成部分.
DOI:10.1021/acs.Joc.9B03011

专利信息

专利号:US-6255545-B1
优先权日:1999-06-11
标 题 :Process for the synthesis of 3,5-bis(trifluoromethyl)-bromobenzene
发明人：CVETOVICH RAYMOND; TSAY FUH-RONG
权利人:MERCK & CO INC
摘要:The present invention is concerned with a novel process for the preparation of 3,5-bis(trifluoromethyl)bromobenzene (CAS 328-70-1). This compound is useful as an intermediate in the synthesis of compounds which possess pharmacological activity.

专利号:US-6600040-B2
优先权日:2000-06-08
标 题:Process for the synthesis of (2R, 2-alpha-R, 3A)-2-[1-(3,5-bis(trifluoromethyl)phenyl)ethoxy]-3-(4-fluorophenyl)-1, 4-oxazine
发明人：BRANDS KAREL M JOS; TSAY FUH-RONG; CONRAD KAREN M; ZHAO MATTHEW M
权利人:MERCK & CO INC
摘要:The present invention is concerned with novel processes for the preparation of (2R, 2-alpha-R, 3a)-2-[1-[3,5-bis(trifluoromethyl)phenyl]ethoxy-3-(4-fluorophenyl)-1,4-oxazine. This compound is useful as an intermediate in the synthesis of compounds which possess pharmacological activity.

专利号:US-6350915-B1
优先权日:1999-06-11
标 题:Process for the synthesis of 1-(3,5-bis(trifluoromethyl)-phenyl)ethan-1-one
发明人：CVETOVICH RAYMOND
权利人:MERCK & CO INC
摘要:The present invention is concerned with a novel process for the preparation of 1-(3,5-bis(trifluromethyl)phenyl)ethan-1-one (CAS 30071-93-3). This compound is useful as an intermediate in the synthesis of therapeutic agents.

专利号:US-6469164-B2
优先权日:2000-06-08
标题:Process for the synthesis of (2R, 2-alpha-R)-4-benzyl-2-[1-(3,5-bis (trifluoromethyl)phenyl)ethoxy]-1,4-oxazine-3-one
发明人：BRANDS KAREL M JOS; PAYACK JOSEPH F; PYE PHILIP J
权利人:MERCK & CO INC
摘要:The present invention is concerned with novel processes for the preparation of (2R, 2-alpha-R)-4-benzyl-2-[1-[3,5-bis(trifluoromethyl)phenyl]ethoxy-1,4-oxazin-3-one. This compound is useful as an intermediate in the synthesis of compounds which possess pharmacological activity.

专利号:US-6489507-B1
优先权日:1999-06-11
标题:Process for the synthesis of 3,5-bis(trifluoromethyl)benzoic acid
发明人：CVETOVICH RAYMOND; LEAZER JOHN
权利人:MERCK & CO INC
摘要:The present invention is concerned with a novel process for the preparation of 3,5-bis(trifluoromethyl)benzoic acid (CAS 725-89-3). This compound is useful as an intermediate in the synthesis of compounds which possess pharmacological activity, in particular, as substance P (neurokinin-1) receptor antagonists.

专利号:US-6777580-B2
优先权日:1999-07-01
标题:Process for the synthesis of (R)-1-(3,5-bis(trifluoromethyl)-phenyl)ethan-1-ol by asymmetric transfer hydrogenation
发明人：DEVINE PAUL; KARL HANSEN
权利人:MERCK & CO INC
摘要:The present invention is concerned with novel processes for the preparation of (R)-1-(3,5-bis(trifluoromethyl)phenyl)ethan-1-ol. This compound is useful as an intermediate in the synthesis of compounds which possess pharmacological activity.