CAS: 81099-86-7; 4-((7-Chloroquinolin-4-yl)Amino)Phenol
该化合物是化学化合物,其独特结构将松碱与氨基氨基化合物和苯球氢基化合物组合在一起,这种化合物通常具有有机溶剂和潜在生物活动中中度溶性等特性,其中可能包括因存在松树环而出现的抗微生物或抗直肠效应,这是许多药用化合物的一个共同特征.quinoline上的氯代成分可增强其再活动性,并可能影响其与生物目标的互动.此外,苯丙基化合物可参与氢联结,这可能影响到化合物的稳定性和再活动性.
- 英文名称4-((7-Chloroquinolin-4-yl)Amino)Phenol
- 中文名称7-氯-4-(4-羟基苯胺基)喹啉
- IUPAC名称4-((7-chloroquinolin-4-yl)amino)phenol
- 其它别名7-Chloro-4-(4-Hydroxyanilino)Quinoline; 7-Chloro-4-P-Hydroxyanilinoquinoline; P-[(7-Chloro-4-Quinolyl)Amino]Phenol; Amodiaquine Impurity C; 7-Chloro-4-(4-Hydroxyphenylamino)Qu; Phenol, 4-[(7-Chloro-4-Quinolinyl)Amino]-
- CAS编号81099-86-7
- MFCD编号:MFCD00034449
- EINECS号:642-212-1
- FDA UNII编号:49F67F98JK
- 分子式:C15H11ClN2O分子量:270.72
- 产品CID: 1805282
- 产品分类分析化学 → 标准品 → 药典标准品和杂质标准品
物理性质
MSDS等安全信息
欧盟法规
ECHA物质C&L通报上下游产品
7-氯-N-(4-甲氧基苯基)喹啉-4-胺 7-Chloro-N-(4-Methoxyphenyl)Quinolin-4-Amine 6059-31-0合成工艺路线路线简述
- 86-98-6 = 81099-86-7
反应条件:1.1 Reagents: Hydrochloric Acid Catalysts: Potassium Iodide Solvents: Ethanol,Water; Rt; 14 H,90 °C
标题:Fragment-Like Chloroquinolineamines Activate The Orphan Nuclear Receptor Nurr1 And Elucidate Activation Mechanisms
作者:Willems,Sabine; Et Al
参考文献:Journal Of Medicinal Chemistry 日期:2021 卷标:64(5) 页码:2659-2668]
23833-97-8 = 81099-86-7
反应条件:1.1 Reagents: Phosphorus Oxychloride; Rt2.1 Solvents: Isopropanol; 90 °C; 4 H,90 °C
标题:Syntheses And Anti-Cholinesterase Activity Of 4-N-Phenylaminoquinoline Derivatives
作者:Liu,Yuming; Et Al
参考文献:Gaodeng Xuexiao Huaxue Xuebao 日期:2017 卷标:38(3) 页码:392-397]
21617-15-2 = 81099-86-7
反应条件:1.1 Solvents: Nitrobenzene; 90 °C2.1 Reagents: Phosphorus Oxychloride; Rt3.1 Solvents: Isopropanol; 90 °C; 4 H,90 °C
标题:Syntheses And Anti-Cholinesterase Activity Of 4-N-Phenylaminoquinoline Derivatives
作者:Liu,Yuming; Et Al
参考文献:Gaodeng Xuexiao Huaxue Xuebao 日期:2017 卷标:38(3) 页码:392-397]
86-98-6 = 81099-86-7
反应条件:1.1 Catalysts: Hydrochloric Acid Solvents: Ethanol
标题:Development Of A New Class Of Nonimidazole Histamine H3 Receptor Ligands With Combined Inhibitory Histamine N-Methyltransferase Activity
作者:Apelt,Joachim; Et Al
参考文献:Journal Of Medicinal Chemistry 日期:2002 卷标:45(5) 页码:1128-1141]
103-90-2 + 86-98-6 = 81099-86-7 [标题:Reaction Conditions
标题:Investigation Of Amodiaquine Bulk Drug Impurities By Liquid Chromatography/ion Trap Mass Spectrometry
作者:Dongre,Vaijanath G.; Et Al
参考文献:Rapid Communications In Mass Spectrometry 日期:2008 卷标:22(14) 页码:2227-2233]
21617-14-1 = 81099-86-7
反应条件:1.1 95 °C2.1 Solvents: Nitrobenzene; 90 °C3.1 Reagents: Phosphorus Oxychloride; Rt4.1 Solvents: Isopropanol; 90 °C; 4 H,90 °C
标题:Syntheses And Anti-Cholinesterase Activity Of 4-N-Phenylaminoquinoline Derivatives
作者:Liu,Yuming; Et Al
参考文献:Gaodeng Xuexiao Huaxue Xuebao 日期:2017 卷标:38(3) 页码:392-397]
= 81099-86-7
反应条件:1.1 15 °C2.1 95 °C3.1 Solvents: Nitrobenzene; 90 °C4.1 Reagents: Phosphorus Oxychloride; Rt5.1 Solvents: Isopropanol; 90 °C; 4 H,90 °C
标题:Syntheses And Anti-Cholinesterase Activity Of 4-N-Phenylaminoquinoline Derivatives
作者:Liu,Yuming; Et Al
参考文献:Gaodeng Xuexiao Huaxue Xuebao 日期:2017 卷标:38(3) 页码:392-397
📜2-(3-Chloro-Anilinomethylene)-N-(4-Methoxy-Phenyl)-Malonamic Acid Ethyl Ester置于氢氧化钾,氢溴酸,三氯氧磷,苯体系中,化学反应生成 7-氯-4-(4-羟基苯胺基)喹啉
参考文献:Sen; Basu,Journal Of The Indian Chemical Society,1957,Vol. 34,P. 906
标题:Sen; Basu,Journal Of The Indian Chemical Society,1957,Vol. 34,P. 906
海关参考信息
- 2903919090-氯苯
2933310010-吡啶
2908199090-其他酚的卤化衍生物
2908999090-其他酚的硝化衍生物 - 💡 提示：海关信息按照顺序优先匹配，如需确认的海关信息，请参考相关资料。
- 详情请参考：📖 海关编码查询和海关进出口税则
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合成参考文献
参考文献:10.1002/rcm.3605
摘要:Dongre VG, Karmuse PP, Ghugare PD, Kanojiya SK, Rawal S. Investigation of amodiaquine bulk drug impurities by liquid chromatography/ion trap mass spectrometry. Rapid Commun Mass Spectrom. 2008 Jul;22(14):2227–33. doi: 10.1002/rcm.3605.
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